Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats

SUMMARY: There is an increasing amount of evidence that supports the diabetic complications of the central nervous system structure and function. The cerebellum, which is one of the primary structure derived from the hindbrain, plays an important role in motor control, motor coordination, and non-mo...

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Autores principales:	Niyomchan,Apichaya, Sricharoenvej,Sirinush, Lanlua,Passara, Baimai,Sani
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Cerebellum Diabetes mellitus Streptozotocin Synaptopathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100028
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spelling	oai:scielo:S0717-950220190001000282019-09-11Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic RatsNiyomchan,ApichayaSricharoenvej,SirinushLanlua,PassaraBaimai,Sani Cerebellum Diabetes mellitus Streptozotocin Synaptopathy SUMMARY: There is an increasing amount of evidence that supports the diabetic complications of the central nervous system structure and function. The cerebellum, which is one of the primary structure derived from the hindbrain, plays an important role in motor control, motor coordination, and non-motor functions, such as cognitive processing. The synapse is a critical structure that regulates neuronal communication, and well-defined afferent and efferent fibre connections in the cerebellum help in maintaining the proper working order. Thus, the present study sought to investigate the long-term effects of diabetes-induced synaptopathy in the cerebellum, using both histological and ultrastructural studies. Twenty Sprague-Dawley male rats were divided randomly into control and diabetic groups, and diabetes was then induced through a single intraperitoneal injection of streptozotocin (60 mg/kg body weight). Six month later, the rats were sacrificed and the cerebellum was removed. Light and electron microscopic examinations showed a degeneration of Purkinje cells (Neuron purkinjense) with shrunken cells, pyknotic nuclei, and synaptopathy, including the reduction in synapse density, number of synaptic vesicles, and maturation of synapses in the molecular layer of diabetic cerebellum. The disruptions in synaptic profiles, which observed in the diabetic condition, could be related to cerebellar dysfunction, thus leading to the defects in coordinated movement, balance, as well as cognitive learning and memory.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100028en10.4067/S0717-95022019000100028
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cerebellum Diabetes mellitus Streptozotocin Synaptopathy
spellingShingle	Cerebellum Diabetes mellitus Streptozotocin Synaptopathy Niyomchan,Apichaya Sricharoenvej,Sirinush Lanlua,Passara Baimai,Sani Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
description	SUMMARY: There is an increasing amount of evidence that supports the diabetic complications of the central nervous system structure and function. The cerebellum, which is one of the primary structure derived from the hindbrain, plays an important role in motor control, motor coordination, and non-motor functions, such as cognitive processing. The synapse is a critical structure that regulates neuronal communication, and well-defined afferent and efferent fibre connections in the cerebellum help in maintaining the proper working order. Thus, the present study sought to investigate the long-term effects of diabetes-induced synaptopathy in the cerebellum, using both histological and ultrastructural studies. Twenty Sprague-Dawley male rats were divided randomly into control and diabetic groups, and diabetes was then induced through a single intraperitoneal injection of streptozotocin (60 mg/kg body weight). Six month later, the rats were sacrificed and the cerebellum was removed. Light and electron microscopic examinations showed a degeneration of Purkinje cells (Neuron purkinjense) with shrunken cells, pyknotic nuclei, and synaptopathy, including the reduction in synapse density, number of synaptic vesicles, and maturation of synapses in the molecular layer of diabetic cerebellum. The disruptions in synaptic profiles, which observed in the diabetic condition, could be related to cerebellar dysfunction, thus leading to the defects in coordinated movement, balance, as well as cognitive learning and memory.
author	Niyomchan,Apichaya Sricharoenvej,Sirinush Lanlua,Passara Baimai,Sani
author_facet	Niyomchan,Apichaya Sricharoenvej,Sirinush Lanlua,Passara Baimai,Sani
author_sort	Niyomchan,Apichaya
title	Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
title_short	Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
title_full	Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
title_fullStr	Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed	Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats
title_sort	cerebellar synaptopathy in streptozotocin-induced diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100028
work_keys_str_mv	AT niyomchanapichaya cerebellarsynaptopathyinstreptozotocininduceddiabeticrats AT sricharoenvejsirinush cerebellarsynaptopathyinstreptozotocininduceddiabeticrats AT lanluapassara cerebellarsynaptopathyinstreptozotocininduceddiabeticrats AT baimaisani cerebellarsynaptopathyinstreptozotocininduceddiabeticrats
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Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats

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