Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period

SUMMARY: This study aimed to investigate the toxic effects of cigarette smoke exposure on lung and the protective role of Omega 3 and Vitamin D against these toxic effects biochemically and histologically. 28 pregnant Wistar Albino rats were divided into four groups. The first group was control grou...

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Autores principales:	Küçük,Zahide, Timur,Burcu, Gözlükgiller,Hayri, Timur,Hakan, Erkenekli,Kudret, Çaydere,Muzaffer, Tokmak,Aytekin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Maternal cigarette smoke Fetal lung MDA and FOU Omega 3, Vitamin D
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100087
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spelling	oai:scielo:S0717-950220190001000872019-09-11Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine PeriodKüçük,ZahideTimur,BurcuGözlükgiller,HayriTimur,HakanErkenekli,KudretÇaydere,MuzafferTokmak,Aytekin Maternal cigarette smoke Fetal lung MDA and FOU Omega 3, Vitamin D SUMMARY: This study aimed to investigate the toxic effects of cigarette smoke exposure on lung and the protective role of Omega 3 and Vitamin D against these toxic effects biochemically and histologically. 28 pregnant Wistar Albino rats were divided into four groups. The first group was control group; the second group was exposed to smoke of 10 cigarette by puff device 2 hours/day after pregnancy; the third group was exposed to cigarette smoke together with Omega 3 (0.5 mg/kg/day) and the fourth group was exposed to cigarette smoke together with vitamin D (42 microgram/kg/day). Finally, lung tissue sections of the newborn rats were stained with Hemotoxilen eosine and Masson tricromite. Malondialdehyde (MDA) and Fluorescent Oxidation Products (FOU) levels were measured. Fetal weights and the number of fetuses were significantly lower in the group received only cigarette smoke (both p<0.001). Histopathologically, pulmonary volume, number of developed alveols and parenchyma elasticity decreased significantly, meanwhile interstitial tissue increased, elastin and collagen did not develop adequately. Histopathologic changes significantly decreased in the group given Omega 3 and Vitamin D. Statistically, MDA and FOU levels were found to be higher in the group exposed to cigarette smoke compared to the control group, and MDA and FOU levels were lower in the group given Omega 3 along with cigarette smoke (p<0.001). Cigarette smoke caused histologically significant damage to fetal lung tissue, oxidative stress and increased MDA and FOU levels. This damage was significantly reduced with Omega 3 and Vitamine D supplementation. Omega 3 is an important antioxidant; vitamin D has no significant antioxidant effect.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100087en10.4067/S0717-95022019000100087
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Maternal cigarette smoke Fetal lung MDA and FOU Omega 3, Vitamin D
spellingShingle	Maternal cigarette smoke Fetal lung MDA and FOU Omega 3, Vitamin D Küçük,Zahide Timur,Burcu Gözlükgiller,Hayri Timur,Hakan Erkenekli,Kudret Çaydere,Muzaffer Tokmak,Aytekin Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
description	SUMMARY: This study aimed to investigate the toxic effects of cigarette smoke exposure on lung and the protective role of Omega 3 and Vitamin D against these toxic effects biochemically and histologically. 28 pregnant Wistar Albino rats were divided into four groups. The first group was control group; the second group was exposed to smoke of 10 cigarette by puff device 2 hours/day after pregnancy; the third group was exposed to cigarette smoke together with Omega 3 (0.5 mg/kg/day) and the fourth group was exposed to cigarette smoke together with vitamin D (42 microgram/kg/day). Finally, lung tissue sections of the newborn rats were stained with Hemotoxilen eosine and Masson tricromite. Malondialdehyde (MDA) and Fluorescent Oxidation Products (FOU) levels were measured. Fetal weights and the number of fetuses were significantly lower in the group received only cigarette smoke (both p<0.001). Histopathologically, pulmonary volume, number of developed alveols and parenchyma elasticity decreased significantly, meanwhile interstitial tissue increased, elastin and collagen did not develop adequately. Histopathologic changes significantly decreased in the group given Omega 3 and Vitamin D. Statistically, MDA and FOU levels were found to be higher in the group exposed to cigarette smoke compared to the control group, and MDA and FOU levels were lower in the group given Omega 3 along with cigarette smoke (p<0.001). Cigarette smoke caused histologically significant damage to fetal lung tissue, oxidative stress and increased MDA and FOU levels. This damage was significantly reduced with Omega 3 and Vitamine D supplementation. Omega 3 is an important antioxidant; vitamin D has no significant antioxidant effect.
author	Küçük,Zahide Timur,Burcu Gözlükgiller,Hayri Timur,Hakan Erkenekli,Kudret Çaydere,Muzaffer Tokmak,Aytekin
author_facet	Küçük,Zahide Timur,Burcu Gözlükgiller,Hayri Timur,Hakan Erkenekli,Kudret Çaydere,Muzaffer Tokmak,Aytekin
author_sort	Küçük,Zahide
title	Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
title_short	Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
title_full	Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
title_fullStr	Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
title_full_unstemmed	Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period
title_sort	protective effect of omega 3 and vitamin d in preventing lung-tissue damage of newborn rats exposed to cigarette smoke during intrauterine period
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100087
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Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period

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