A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury

SUMMARY: Endoneurial oedema is a salient feature of all types of neuropathy. Its elimination is crucial during the complications of nerve recovery. The objective was to study a possible role of the endoneurial fibroblasts in the resolution of nerve edema. Forty-two albino male rats aged between 30 a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elbarrany,Wagih G, Alasmari,Wardah A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Sural Nerve Endoneurial Fibroblast-Like Cells Endoneurial Oedema Barrier-Like And Channel-Like Spaces
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100141
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022019000100141
record_format	dspace
spelling	oai:scielo:S0717-950220190001001412019-09-11A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush InjuryElbarrany,Wagih GAlasmari,Wardah A Sural Nerve Endoneurial Fibroblast-Like Cells Endoneurial Oedema Barrier-Like And Channel-Like Spaces SUMMARY: Endoneurial oedema is a salient feature of all types of neuropathy. Its elimination is crucial during the complications of nerve recovery. The objective was to study a possible role of the endoneurial fibroblasts in the resolution of nerve edema. Forty-two albino male rats aged between 30 and 40 days (weight 200 g to 250 g) were used in this study. The left sural nerves of 36 rats were subjected to crush injury at one to three-week intervals with six animals per interval. The right and left sural nerves of the remaining six rats were used as controls. At the end of the second week after crush injury, the endoneurium showed channel-like spaces that were lined by fibroblast-like cells and collagen bundles that contained degenerated myelin, and were connected to the subperineurial spaces. Flattened fibroblast-like cells were arranged in several layers in the subperineurial, forming barrier-like cellular sheets localizing to the endoneurial oedema in the space. Fibroblast-like cells also wrapped around the regenerating nerve fibres with their branching cytoplasmic processes. During the third week, the flattened fibroblast-like cells formed nearly continuous cellular sheets in the subperineurial spaces. Macrophages were frequently observed between these cellular barrier-like sheets and in the subperineurial. The endoneurial fibroblast-like cells form barrier-like cellular sheets that probably localise the endoneurial oedema in the subperineurial space. It also appear to create endoneurial channel-like spaces containing degenerated myelin and endoneurial oedema, which may be helpful in localizing and resolving such oedema.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100141en10.4067/S0717-95022019000100141
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sural Nerve Endoneurial Fibroblast-Like Cells Endoneurial Oedema Barrier-Like And Channel-Like Spaces
spellingShingle	Sural Nerve Endoneurial Fibroblast-Like Cells Endoneurial Oedema Barrier-Like And Channel-Like Spaces Elbarrany,Wagih G Alasmari,Wardah A A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
description	SUMMARY: Endoneurial oedema is a salient feature of all types of neuropathy. Its elimination is crucial during the complications of nerve recovery. The objective was to study a possible role of the endoneurial fibroblasts in the resolution of nerve edema. Forty-two albino male rats aged between 30 and 40 days (weight 200 g to 250 g) were used in this study. The left sural nerves of 36 rats were subjected to crush injury at one to three-week intervals with six animals per interval. The right and left sural nerves of the remaining six rats were used as controls. At the end of the second week after crush injury, the endoneurium showed channel-like spaces that were lined by fibroblast-like cells and collagen bundles that contained degenerated myelin, and were connected to the subperineurial spaces. Flattened fibroblast-like cells were arranged in several layers in the subperineurial, forming barrier-like cellular sheets localizing to the endoneurial oedema in the space. Fibroblast-like cells also wrapped around the regenerating nerve fibres with their branching cytoplasmic processes. During the third week, the flattened fibroblast-like cells formed nearly continuous cellular sheets in the subperineurial spaces. Macrophages were frequently observed between these cellular barrier-like sheets and in the subperineurial. The endoneurial fibroblast-like cells form barrier-like cellular sheets that probably localise the endoneurial oedema in the subperineurial space. It also appear to create endoneurial channel-like spaces containing degenerated myelin and endoneurial oedema, which may be helpful in localizing and resolving such oedema.
author	Elbarrany,Wagih G Alasmari,Wardah A
author_facet	Elbarrany,Wagih G Alasmari,Wardah A
author_sort	Elbarrany,Wagih G
title	A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
title_short	A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
title_full	A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
title_fullStr	A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
title_full_unstemmed	A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury
title_sort	possible role of endoneurial fibroblast-like cells in the resolution of endoneurial oedema following nerve crush injury
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100141
work_keys_str_mv	AT elbarranywagihg apossibleroleofendoneurialfibroblastlikecellsintheresolutionofendoneurialoedemafollowingnervecrushinjury AT alasmariwardaha apossibleroleofendoneurialfibroblastlikecellsintheresolutionofendoneurialoedemafollowingnervecrushinjury AT elbarranywagihg possibleroleofendoneurialfibroblastlikecellsintheresolutionofendoneurialoedemafollowingnervecrushinjury AT alasmariwardaha possibleroleofendoneurialfibroblastlikecellsintheresolutionofendoneurialoedemafollowingnervecrushinjury
_version_	1718445086963924992

A Possible Role of Endoneurial Fibroblast-Like Cells in the Resolution of Endoneurial Oedema Following Nerve Crush Injury

Ejemplares similares