Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats

SUMMARY: Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar ra...

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Autores principales:	Azubuike,Nkiruka C, Okwuosa,Chukwugozie N, Maduakor,Uzoamaka C, Onwukwe,Okechukwu S, Onyemelukwe,Anulika O, Ogu,Cornelius O, Ikele,Ikenna T, Oparah,Chioma L, Akande,Adeniyi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Brassica juncea Seeds histopathology Heart Liver Serum biochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100237
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spelling	oai:scielo:S0717-950220190001002372019-09-11Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino RatsAzubuike,Nkiruka COkwuosa,Chukwugozie NMaduakor,Uzoamaka COnwukwe,Okechukwu SOnyemelukwe,Anulika OOgu,Cornelius OIkele,Ikenna TOparah,Chioma LAkande,Adeniyi Brassica juncea Seeds histopathology Heart Liver Serum biochemistry SUMMARY: Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar rats. A total of 24 albino rats of both sexes were divided into 6 groups [I - VI] of 4 rats per group. Groups I to IV received graded doses of the methanol extract by oral gavage while groups V and VI (controls) received 2 ml/kg body weight of 3 % Tween 80 and water respectively via oral gavage once daily. Treatment lasted for four weeks and the serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated. The animals were sacrificed and the heart and liver tissues were excised for further histological processing for light microscopy. There was significant increase in AST and ALT levels following BJME treatment when compared to the controls. ALP activity did not differ significantly among the treatment and control groups. Histopathological changes consistent with toxic injury were observed in the heart and liver tissues of BJME- treated rats. In conclusion, the results of this study show that sub-acute administration of methanol seed extract of Brassica juncea can exert cardiotoxic and hepatotoxic effects in rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100237en10.4067/S0717-95022019000100237
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Brassica juncea Seeds histopathology Heart Liver Serum biochemistry
spellingShingle	Brassica juncea Seeds histopathology Heart Liver Serum biochemistry Azubuike,Nkiruka C Okwuosa,Chukwugozie N Maduakor,Uzoamaka C Onwukwe,Okechukwu S Onyemelukwe,Anulika O Ogu,Cornelius O Ikele,Ikenna T Oparah,Chioma L Akande,Adeniyi Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
description	SUMMARY: Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar rats. A total of 24 albino rats of both sexes were divided into 6 groups [I - VI] of 4 rats per group. Groups I to IV received graded doses of the methanol extract by oral gavage while groups V and VI (controls) received 2 ml/kg body weight of 3 % Tween 80 and water respectively via oral gavage once daily. Treatment lasted for four weeks and the serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated. The animals were sacrificed and the heart and liver tissues were excised for further histological processing for light microscopy. There was significant increase in AST and ALT levels following BJME treatment when compared to the controls. ALP activity did not differ significantly among the treatment and control groups. Histopathological changes consistent with toxic injury were observed in the heart and liver tissues of BJME- treated rats. In conclusion, the results of this study show that sub-acute administration of methanol seed extract of Brassica juncea can exert cardiotoxic and hepatotoxic effects in rats.
author	Azubuike,Nkiruka C Okwuosa,Chukwugozie N Maduakor,Uzoamaka C Onwukwe,Okechukwu S Onyemelukwe,Anulika O Ogu,Cornelius O Ikele,Ikenna T Oparah,Chioma L Akande,Adeniyi
author_facet	Azubuike,Nkiruka C Okwuosa,Chukwugozie N Maduakor,Uzoamaka C Onwukwe,Okechukwu S Onyemelukwe,Anulika O Ogu,Cornelius O Ikele,Ikenna T Oparah,Chioma L Akande,Adeniyi
author_sort	Azubuike,Nkiruka C
title	Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
title_short	Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
title_full	Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
title_fullStr	Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
title_full_unstemmed	Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats
title_sort	effects of methanolic extract of brassica juncea seeds on biochemical parameters and histological integrity of the heart and liver of albino rats
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100237
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Effects of Methanolic Extract of Brassica juncea Seeds on Biochemical Parameters and Histological Integrity of the Heart and Liver of Albino Rats

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