1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats

SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural compon...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Snehunsu,Adhikari, Nayak,Satheesha B, Kandwal,Mamta, Piyali,Adhikari, Adiga,Murali, Sahoo,Pabitra, Medabala,T, Raghavenra-Rao,K, Joseph,Alex
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	1-Triacontanol cerotate Marsilea quadrifolia Linn Pentylenetetrazol Epilepsy Hippocampal CA3 zone Pyramidal cells Brain antioxidants Cresyl Violet
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100265
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022019000100265
record_format	dspace
spelling	oai:scielo:S0717-950220190001002652019-09-111-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic ratsSnehunsu,AdhikariNayak,Satheesha BKandwal,MamtaPiyali,AdhikariAdiga,MuraliSahoo,PabitraMedabala,TRaghavenra-Rao,KJoseph,Alex 1-Triacontanol cerotate Marsilea quadrifolia Linn Pentylenetetrazol Epilepsy Hippocampal CA3 zone Pyramidal cells Brain antioxidants Cresyl Violet SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC: 40 mg/kg) & VI (1TAC: 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100265en10.4067/S0717-95022019000100265
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	1-Triacontanol cerotate Marsilea quadrifolia Linn Pentylenetetrazol Epilepsy Hippocampal CA3 zone Pyramidal cells Brain antioxidants Cresyl Violet
spellingShingle	1-Triacontanol cerotate Marsilea quadrifolia Linn Pentylenetetrazol Epilepsy Hippocampal CA3 zone Pyramidal cells Brain antioxidants Cresyl Violet Snehunsu,Adhikari Nayak,Satheesha B Kandwal,Mamta Piyali,Adhikari Adiga,Murali Sahoo,Pabitra Medabala,T Raghavenra-Rao,K Joseph,Alex 1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
description	SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC: 40 mg/kg) & VI (1TAC: 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.
author	Snehunsu,Adhikari Nayak,Satheesha B Kandwal,Mamta Piyali,Adhikari Adiga,Murali Sahoo,Pabitra Medabala,T Raghavenra-Rao,K Joseph,Alex
author_facet	Snehunsu,Adhikari Nayak,Satheesha B Kandwal,Mamta Piyali,Adhikari Adiga,Murali Sahoo,Pabitra Medabala,T Raghavenra-Rao,K Joseph,Alex
author_sort	Snehunsu,Adhikari
title	1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
title_short	1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
title_full	1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
title_fullStr	1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
title_full_unstemmed	1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats
title_sort	1-triacontanol cerotate isolated from marsilea quadrifolia linn. safeguards hippocampal ca3 neurons and augments special memory deficit in chronic epileptic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100265
work_keys_str_mv	AT snehunsuadhikari 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT nayaksatheeshab 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT kandwalmamta 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT piyaliadhikari 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT adigamurali 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT sahoopabitra 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT medabalat 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT raghavenraraok 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats AT josephalex 1triacontanolcerotateisolatedfrommarsileaquadrifolialinnsafeguardshippocampalca3neuronsandaugmentsspecialmemorydeficitinchronicepilepticrats
_version_	1718445090460925952

1-Triacontanol Cerotate Isolated from Marsilea quadrifolia Linn. Safeguards Hippocampal CA3 Neurons and Augments Special Memory Deficit in Chronic Epileptic rats

Ejemplares similares