Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?

SUMMARY: Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rat...

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Autores principales:	ElSawy,Naser A, Alkushi,Abdullah G, Alasmari,Wardah Abdullah Mohammed, Sinna,Mustafa M, Header,Eslam A, Elmadbouly,Mohammad A, Sakran,Ashraf Mohamed Elsayed Ali
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Origanum vulgare Ethylene glycol Testicular damage
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100358
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spelling	oai:scielo:S0717-950220190001003582019-09-11Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?ElSawy,Naser AAlkushi,Abdullah GAlasmari,Wardah Abdullah MohammedSinna,Mustafa MHeader,Eslam AElmadbouly,Mohammad ASakran,Ashraf Mohamed Elsayed Ali Origanum vulgare Ethylene glycol Testicular damage SUMMARY: Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rationalize its medicinal use. Male Wistar rats received lithogenic treatment comprising of 0.75 % ethylene glycol injection twice with one day interval, then in drinking water, active extract of Origanum vulgare treatment (20 mg/kg) was given for 3 weeks to prevent toxic damage including loss of body weight gain and appetite, Following oral administration of EGME, a rapid decrease in testis weight associated with testicular cell damage was observed. Origanum vulgare treatment (20 mg/kg) prevented as well as reversed toxic changes including loss of body weight gain.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.1 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100358en10.4067/S0717-95022019000100358
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Origanum vulgare Ethylene glycol Testicular damage
spellingShingle	Origanum vulgare Ethylene glycol Testicular damage ElSawy,Naser A Alkushi,Abdullah G Alasmari,Wardah Abdullah Mohammed Sinna,Mustafa M Header,Eslam A Elmadbouly,Mohammad A Sakran,Ashraf Mohamed Elsayed Ali Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
description	SUMMARY: Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rationalize its medicinal use. Male Wistar rats received lithogenic treatment comprising of 0.75 % ethylene glycol injection twice with one day interval, then in drinking water, active extract of Origanum vulgare treatment (20 mg/kg) was given for 3 weeks to prevent toxic damage including loss of body weight gain and appetite, Following oral administration of EGME, a rapid decrease in testis weight associated with testicular cell damage was observed. Origanum vulgare treatment (20 mg/kg) prevented as well as reversed toxic changes including loss of body weight gain.
author	ElSawy,Naser A Alkushi,Abdullah G Alasmari,Wardah Abdullah Mohammed Sinna,Mustafa M Header,Eslam A Elmadbouly,Mohammad A Sakran,Ashraf Mohamed Elsayed Ali
author_facet	ElSawy,Naser A Alkushi,Abdullah G Alasmari,Wardah Abdullah Mohammed Sinna,Mustafa M Header,Eslam A Elmadbouly,Mohammad A Sakran,Ashraf Mohamed Elsayed Ali
author_sort	ElSawy,Naser A
title	Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
title_short	Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
title_full	Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
title_fullStr	Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
title_full_unstemmed	Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?
title_sort	does oregano protect against testicular toxicity produced by ethylene glycol in adult male albino rat?
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000100358
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Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?

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