Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat

SUMMARY: AQP1 plays an essential role in maintaining body water balance. In the kidney, AQP1 is localized to the apical and basolateral membrane of epithelial cells in the proximal tubule and descending thin limb of Ansa nephroni (Henle’s loop) where it reabsorbs the vast majority of filte...

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Autores principales:	Wang,Jinbao, Yang,Wen, Wang,Pei, Wu,Jing, Wang,Zhisheng, Yang,Mengmeng, Jin,Xueqin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Obesity Kidney AQP1 Obesity-related kidney disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200406
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spelling	oai:scielo:S0717-950220190002004062019-09-11Renal Expression of AQP1 in the High-fat Nutritional Obesity of RatWang,JinbaoYang,WenWang,PeiWu,JingWang,ZhishengYang,MengmengJin,Xueqin Obesity Kidney AQP1 Obesity-related kidney disease SUMMARY: AQP1 plays an essential role in maintaining body water balance. In the kidney, AQP1 is localized to the apical and basolateral membrane of epithelial cells in the proximal tubule and descending thin limb of Ansa nephroni (Henle’s loop) where it reabsorbs the vast majority of filtered water. The growing epidemic of obesity and metabolic diseases particularly obesity-related kidney disease is getting more and more attention in this century. However, a full understanding of mechanisms involved to the progressive renal disease is still unclear, in particular AQPs in the kidney of obesity. In this paper, we examined the localization of AQP1 in renal cortex and medulla of ND (normal diet) and HFD (high-fat diet) at rats. In the renal cortex and medulla, immunolight microscopy revealed weak expression of AQP1 in the apical and basolateral membrane of epithelial cells at the proximal straight/convoluted tubule of HFD compared with ND, respectively. The same result was confirmed in the thick descending limb and descending thin limb of Henle’s loop. In the high-fat nutritional obesity of rats, decreased AQP1 levels may not directly cause serious obesity-related kidney disease, e.g. chronic kidney disease, even end-stage renal disease. But at least, AQPs (AQP1 in this study) was one of initially conditions to the incentive of obesity-related kidney disease.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200406en10.4067/S0717-95022019000200406
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Obesity Kidney AQP1 Obesity-related kidney disease
spellingShingle	Obesity Kidney AQP1 Obesity-related kidney disease Wang,Jinbao Yang,Wen Wang,Pei Wu,Jing Wang,Zhisheng Yang,Mengmeng Jin,Xueqin Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
description	SUMMARY: AQP1 plays an essential role in maintaining body water balance. In the kidney, AQP1 is localized to the apical and basolateral membrane of epithelial cells in the proximal tubule and descending thin limb of Ansa nephroni (Henle’s loop) where it reabsorbs the vast majority of filtered water. The growing epidemic of obesity and metabolic diseases particularly obesity-related kidney disease is getting more and more attention in this century. However, a full understanding of mechanisms involved to the progressive renal disease is still unclear, in particular AQPs in the kidney of obesity. In this paper, we examined the localization of AQP1 in renal cortex and medulla of ND (normal diet) and HFD (high-fat diet) at rats. In the renal cortex and medulla, immunolight microscopy revealed weak expression of AQP1 in the apical and basolateral membrane of epithelial cells at the proximal straight/convoluted tubule of HFD compared with ND, respectively. The same result was confirmed in the thick descending limb and descending thin limb of Henle’s loop. In the high-fat nutritional obesity of rats, decreased AQP1 levels may not directly cause serious obesity-related kidney disease, e.g. chronic kidney disease, even end-stage renal disease. But at least, AQPs (AQP1 in this study) was one of initially conditions to the incentive of obesity-related kidney disease.
author	Wang,Jinbao Yang,Wen Wang,Pei Wu,Jing Wang,Zhisheng Yang,Mengmeng Jin,Xueqin
author_facet	Wang,Jinbao Yang,Wen Wang,Pei Wu,Jing Wang,Zhisheng Yang,Mengmeng Jin,Xueqin
author_sort	Wang,Jinbao
title	Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
title_short	Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
title_full	Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
title_fullStr	Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
title_full_unstemmed	Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat
title_sort	renal expression of aqp1 in the high-fat nutritional obesity of rat
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200406
work_keys_str_mv	AT wangjinbao renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT yangwen renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT wangpei renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT wujing renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT wangzhisheng renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT yangmengmeng renalexpressionofaqp1inthehighfatnutritionalobesityofrat AT jinxueqin renalexpressionofaqp1inthehighfatnutritionalobesityofrat
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Renal Expression of AQP1 in the High-fat Nutritional Obesity of Rat

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