Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study

SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to eva...

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Autores principales:	Bin-Meferij,Mashael Mohammed, El-Kott,Attalla Farag, Shati,Ali Abdullah, Eid,Refaat A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Ginger extract Renal histology High-fat diet (HFD) Obesity Ultrastructural Leptin TNF-α
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438
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spelling	oai:scielo:S0717-950220190002004382019-09-11Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural StudyBin-Meferij,Mashael MohammedEl-Kott,Attalla FaragShati,Ali AbdullahEid,Refaat A Ginger extract Renal histology High-fat diet (HFD) Obesity Ultrastructural Leptin TNF-α SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to evaluate the Zingiber officinale protective effect against obesity complications which induced by high fat diet and caused renal dysfunctions. The study period was two months, and the experimental animals’ groups were four, 80 Wistar rats were appropriated similarly 20 animals/group: control group; ginger extract group (GE); high-fat diet (HFD); and GE+HFD group. Body and fat weight, creatinine, leptin, TNF-α, total antioxidants, renal histopathological and ultrastructure were investigated. Rats in group of HFD showed a significant increase (P<0.05) in the body and fat weights, creatinine, leptin and TNF-α, and significant decrease (P<0.05) in total antioxidants (TAS). Ginger administration significantly showed the protective restoring the altered parameters. Furthermore, rats co-treated with ginger extract improved the histopathological and ultrastructural renal injury induced by obesity. The study concluded that the ginger extract used could suppress and decrease the renal damage induced by high-fat diet as it possesses potential medicinal values.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438en10.4067/S0717-95022019000200438
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ginger extract Renal histology High-fat diet (HFD) Obesity Ultrastructural Leptin TNF-α
spellingShingle	Ginger extract Renal histology High-fat diet (HFD) Obesity Ultrastructural Leptin TNF-α Bin-Meferij,Mashael Mohammed El-Kott,Attalla Farag Shati,Ali Abdullah Eid,Refaat A Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
description	SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to evaluate the Zingiber officinale protective effect against obesity complications which induced by high fat diet and caused renal dysfunctions. The study period was two months, and the experimental animals’ groups were four, 80 Wistar rats were appropriated similarly 20 animals/group: control group; ginger extract group (GE); high-fat diet (HFD); and GE+HFD group. Body and fat weight, creatinine, leptin, TNF-α, total antioxidants, renal histopathological and ultrastructure were investigated. Rats in group of HFD showed a significant increase (P<0.05) in the body and fat weights, creatinine, leptin and TNF-α, and significant decrease (P<0.05) in total antioxidants (TAS). Ginger administration significantly showed the protective restoring the altered parameters. Furthermore, rats co-treated with ginger extract improved the histopathological and ultrastructural renal injury induced by obesity. The study concluded that the ginger extract used could suppress and decrease the renal damage induced by high-fat diet as it possesses potential medicinal values.
author	Bin-Meferij,Mashael Mohammed El-Kott,Attalla Farag Shati,Ali Abdullah Eid,Refaat A
author_facet	Bin-Meferij,Mashael Mohammed El-Kott,Attalla Farag Shati,Ali Abdullah Eid,Refaat A
author_sort	Bin-Meferij,Mashael Mohammed
title	Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_short	Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_full	Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_fullStr	Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_full_unstemmed	Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_sort	ginger extract ameliorates renal damage in high fat diet-induced obesity in rats: biochemical and ultrastructural study
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438
work_keys_str_mv	AT binmeferijmashaelmohammed gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy AT elkottattallafarag gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy AT shatialiabdullah gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy AT eidrefaata gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy
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Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study

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