Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study

SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to eva...

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Autores principales: Bin-Meferij,Mashael Mohammed, El-Kott,Attalla Farag, Shati,Ali Abdullah, Eid,Refaat A
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2019
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438
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spelling oai:scielo:S0717-950220190002004382019-09-11Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural StudyBin-Meferij,Mashael MohammedEl-Kott,Attalla FaragShati,Ali AbdullahEid,Refaat A Ginger extract Renal histology High-fat diet (HFD) Obesity Ultrastructural Leptin TNF-&#945; SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to evaluate the Zingiber officinale protective effect against obesity complications which induced by high fat diet and caused renal dysfunctions. The study period was two months, and the experimental animals&#8217; groups were four, 80 Wistar rats were appropriated similarly 20 animals/group: control group; ginger extract group (GE); high-fat diet (HFD); and GE+HFD group. Body and fat weight, creatinine, leptin, TNF-&#945;, total antioxidants, renal histopathological and ultrastructure were investigated. Rats in group of HFD showed a significant increase (P<0.05) in the body and fat weights, creatinine, leptin and TNF-&#945;, and significant decrease (P<0.05) in total antioxidants (TAS). Ginger administration significantly showed the protective restoring the altered parameters. Furthermore, rats co-treated with ginger extract improved the histopathological and ultrastructural renal injury induced by obesity. The study concluded that the ginger extract used could suppress and decrease the renal damage induced by high-fat diet as it possesses potential medicinal values.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438en10.4067/S0717-95022019000200438
institution Scielo Chile
collection Scielo Chile
language English
topic Ginger extract
Renal histology
High-fat diet (HFD)
Obesity
Ultrastructural
Leptin
TNF-&#945;
spellingShingle Ginger extract
Renal histology
High-fat diet (HFD)
Obesity
Ultrastructural
Leptin
TNF-&#945;
Bin-Meferij,Mashael Mohammed
El-Kott,Attalla Farag
Shati,Ali Abdullah
Eid,Refaat A
Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
description SUMMARY: Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to evaluate the Zingiber officinale protective effect against obesity complications which induced by high fat diet and caused renal dysfunctions. The study period was two months, and the experimental animals&#8217; groups were four, 80 Wistar rats were appropriated similarly 20 animals/group: control group; ginger extract group (GE); high-fat diet (HFD); and GE+HFD group. Body and fat weight, creatinine, leptin, TNF-&#945;, total antioxidants, renal histopathological and ultrastructure were investigated. Rats in group of HFD showed a significant increase (P<0.05) in the body and fat weights, creatinine, leptin and TNF-&#945;, and significant decrease (P<0.05) in total antioxidants (TAS). Ginger administration significantly showed the protective restoring the altered parameters. Furthermore, rats co-treated with ginger extract improved the histopathological and ultrastructural renal injury induced by obesity. The study concluded that the ginger extract used could suppress and decrease the renal damage induced by high-fat diet as it possesses potential medicinal values.
author Bin-Meferij,Mashael Mohammed
El-Kott,Attalla Farag
Shati,Ali Abdullah
Eid,Refaat A
author_facet Bin-Meferij,Mashael Mohammed
El-Kott,Attalla Farag
Shati,Ali Abdullah
Eid,Refaat A
author_sort Bin-Meferij,Mashael Mohammed
title Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_short Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_full Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_fullStr Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_full_unstemmed Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity in Rats: Biochemical and Ultrastructural Study
title_sort ginger extract ameliorates renal damage in high fat diet-induced obesity in rats: biochemical and ultrastructural study
publisher Sociedad Chilena de Anatomía
publishDate 2019
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200438
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AT elkottattallafarag gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy
AT shatialiabdullah gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy
AT eidrefaata gingerextractamelioratesrenaldamageinhighfatdietinducedobesityinratsbiochemicalandultrastructuralstudy
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