Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat

SUMMARY: Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. Eight of the AQPs are expressed in the kidney, where several of them contribute to water absorption and maintenance o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang,Jinbao, Wang,Pei, Wang,Zhisheng, Ran,Linwu, Yang,Li, Yang,Wen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Obesity Kidney AQPs V2R Kidney disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200459
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022019000200459
record_format	dspace
spelling	oai:scielo:S0717-950220190002004592019-09-11Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of RatWang,JinbaoWang,PeiWang,ZhishengRan,LinwuYang,LiYang,Wen Obesity Kidney AQPs V2R Kidney disease SUMMARY: Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. Eight of the AQPs are expressed in the kidney, where several of them contribute to water absorption and maintenance of body water balance. In the study, we mainly examined the localization of AQP2, AQP3 and V2R in renal medulla of Normal Diet (ND) and High-fat Diet (HFD) of rats, respectively. In renal medulla of HFD, immunolight microscopy revealed weak expression of AQP2 at the apical plasma membrane and intracellular vesicles of principal cells of the IMCD and OMCD. AQP3 and V2R expression also observed a decrease in immunolabelling in the IMCD and OMCD. It was suggested that excess lipid accumulation may lead to lipotoxicity and may be the major driver of organ dysfunction such as water reabsorption dysfunction, which may be resulted from abnormal response of rphan G-protein-coupled receptors in kidney.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200459en10.4067/S0717-95022019000200459
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Obesity Kidney AQPs V2R Kidney disease
spellingShingle	Obesity Kidney AQPs V2R Kidney disease Wang,Jinbao Wang,Pei Wang,Zhisheng Ran,Linwu Yang,Li Yang,Wen Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
description	SUMMARY: Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. Eight of the AQPs are expressed in the kidney, where several of them contribute to water absorption and maintenance of body water balance. In the study, we mainly examined the localization of AQP2, AQP3 and V2R in renal medulla of Normal Diet (ND) and High-fat Diet (HFD) of rats, respectively. In renal medulla of HFD, immunolight microscopy revealed weak expression of AQP2 at the apical plasma membrane and intracellular vesicles of principal cells of the IMCD and OMCD. AQP3 and V2R expression also observed a decrease in immunolabelling in the IMCD and OMCD. It was suggested that excess lipid accumulation may lead to lipotoxicity and may be the major driver of organ dysfunction such as water reabsorption dysfunction, which may be resulted from abnormal response of rphan G-protein-coupled receptors in kidney.
author	Wang,Jinbao Wang,Pei Wang,Zhisheng Ran,Linwu Yang,Li Yang,Wen
author_facet	Wang,Jinbao Wang,Pei Wang,Zhisheng Ran,Linwu Yang,Li Yang,Wen
author_sort	Wang,Jinbao
title	Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
title_short	Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
title_full	Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
title_fullStr	Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
title_full_unstemmed	Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat
title_sort	expression of v2r and aqps in the renal medulla of high-fat nutritional obesity of rat
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200459
work_keys_str_mv	AT wangjinbao expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat AT wangpei expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat AT wangzhisheng expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat AT ranlinwu expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat AT yangli expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat AT yangwen expressionofv2randaqpsintherenalmedullaofhighfatnutritionalobesityofrat
_version_	1718445095888355328

Expression of V2R and AQPs in the Renal Medulla of High-fat Nutritional Obesity of Rat

Ejemplares similares