Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy

SUMMARY: Cisplatin is an antineoplastic agent with neuropathy as one of its major side effect. However, effective treatment is lacking. Increasing evidence suggests that cisplatin might damage nerve capillaries leading to impaired functions of blood-nerve barrier (BNB) and neuropathy. This study was...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jindatip,Depicha, Nopparat,Worapat, Kobutree,Phetnarin, Roumwong,Atitaya, Agthong,Sithiporn
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Pericyte Cisplatin Nerve Neuropathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200509
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022019000200509
record_format	dspace
spelling	oai:scielo:S0717-950220190002005092019-09-11Pericyte Loss and Detachment in Experimental Cisplatin-Induced NeuropathyJindatip,DepichaNopparat,WorapatKobutree,PhetnarinRoumwong,AtitayaAgthong,Sithiporn Pericyte Cisplatin Nerve Neuropathy SUMMARY: Cisplatin is an antineoplastic agent with neuropathy as one of its major side effect. However, effective treatment is lacking. Increasing evidence suggests that cisplatin might damage nerve capillaries leading to impaired functions of blood-nerve barrier (BNB) and neuropathy. This study was aimed to examine the effects of cisplatin on pericytes. Rats were either treated with intraperitoneal injection of cisplatin 2 mg/kg twice a week for five continuous weeks. Cisplatin-treated rats showed reduced body weight, thermal hypoalgesia and slow sciatic motor nerve conduction velocity, indicating neuropathy. The density of pericytes in the distal sciatic nerves determined by immunohistochemistry to desmin was significantly reduced in the cisplatin compared with that of the control groups. Electron microscopic analysis demonstrated the detachment of pericytes from endothelial cells including the disruption of shared basement membrane in the sciatic nerves from cisplatin-treated rats. These data indicate the pericyte loss and detachment caused by cisplatin. Future studies of the BNB components and functions after cisplatin treatment are needed and will be essential for the development of effective treatments against cisplatin-induced neuropathy.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200509en10.4067/S0717-95022019000200509
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pericyte Cisplatin Nerve Neuropathy
spellingShingle	Pericyte Cisplatin Nerve Neuropathy Jindatip,Depicha Nopparat,Worapat Kobutree,Phetnarin Roumwong,Atitaya Agthong,Sithiporn Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
description	SUMMARY: Cisplatin is an antineoplastic agent with neuropathy as one of its major side effect. However, effective treatment is lacking. Increasing evidence suggests that cisplatin might damage nerve capillaries leading to impaired functions of blood-nerve barrier (BNB) and neuropathy. This study was aimed to examine the effects of cisplatin on pericytes. Rats were either treated with intraperitoneal injection of cisplatin 2 mg/kg twice a week for five continuous weeks. Cisplatin-treated rats showed reduced body weight, thermal hypoalgesia and slow sciatic motor nerve conduction velocity, indicating neuropathy. The density of pericytes in the distal sciatic nerves determined by immunohistochemistry to desmin was significantly reduced in the cisplatin compared with that of the control groups. Electron microscopic analysis demonstrated the detachment of pericytes from endothelial cells including the disruption of shared basement membrane in the sciatic nerves from cisplatin-treated rats. These data indicate the pericyte loss and detachment caused by cisplatin. Future studies of the BNB components and functions after cisplatin treatment are needed and will be essential for the development of effective treatments against cisplatin-induced neuropathy.
author	Jindatip,Depicha Nopparat,Worapat Kobutree,Phetnarin Roumwong,Atitaya Agthong,Sithiporn
author_facet	Jindatip,Depicha Nopparat,Worapat Kobutree,Phetnarin Roumwong,Atitaya Agthong,Sithiporn
author_sort	Jindatip,Depicha
title	Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
title_short	Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
title_full	Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
title_fullStr	Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
title_full_unstemmed	Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy
title_sort	pericyte loss and detachment in experimental cisplatin-induced neuropathy
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200509
work_keys_str_mv	AT jindatipdepicha pericytelossanddetachmentinexperimentalcisplatininducedneuropathy AT nopparatworapat pericytelossanddetachmentinexperimentalcisplatininducedneuropathy AT kobutreephetnarin pericytelossanddetachmentinexperimentalcisplatininducedneuropathy AT roumwongatitaya pericytelossanddetachmentinexperimentalcisplatininducedneuropathy AT agthongsithiporn pericytelossanddetachmentinexperimentalcisplatininducedneuropathy
_version_	1718445097520988160

Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy

Ejemplares similares