Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study

SUMMARY: Antidepressants use during pregnancy was associated with an increased risk of autism spectrum disorders. Animal models based on early life alterations in serotonin availability replicate some of the anatomical and behavioral abnormalities observed in autistic individuals. In recent years th...

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Autores principales:	Kalbouneh,Heba M, Alzghoul,Loai A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Antidepressant Hippocampus Autism Cell density Citalopram neonatal exposure
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200576
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spelling	oai:scielo:S0717-950220190002005762019-09-11Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl StudyKalbouneh,Heba MAlzghoul,Loai A Antidepressant Hippocampus Autism Cell density Citalopram neonatal exposure SUMMARY: Antidepressants use during pregnancy was associated with an increased risk of autism spectrum disorders. Animal models based on early life alterations in serotonin availability replicate some of the anatomical and behavioral abnormalities observed in autistic individuals. In recent years there has been a growing interest in the possible role of the hippocampus in autism. The aim of study is to examine the effects of neonatal antidepressant (CTM) exposure during a sensitive period of brain development on pyramidal and granule cells density of hippocampal formation. We examined the pyramidal and granular cells density of dorsal hippocampus using Nissl stained sections obtained from neonatal citalopram (CTM) exposed rats (5 mg/kg, twice daily, s.c.), from postnatal day 8 to 21 (PN8-21), saline and non-exposed rats. The density of pyramidal cells was significantly increased by 10.2 % in CA1, 10.6 % in CA3 and 13.2 % in CA4 in CTM treated compared with non-treated or saline treated animals (p<0.0001). The density of granule cells in the dentate gyrus was significantly increased by 12.0 % in CTM treated compared with non-treated or saline treated animals (p<0.0001). These findings were obtained only from male rats, suggesting a sexual dimorphism in neural development after SSRI exposure. These data suggest that the neonatal exposure to CTM may induce long-lasting changes in the hippcampal formation in adults, and such effects appear to preferentially target males.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200576en10.4067/S0717-95022019000200576
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antidepressant Hippocampus Autism Cell density Citalopram neonatal exposure
spellingShingle	Antidepressant Hippocampus Autism Cell density Citalopram neonatal exposure Kalbouneh,Heba M Alzghoul,Loai A Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
description	SUMMARY: Antidepressants use during pregnancy was associated with an increased risk of autism spectrum disorders. Animal models based on early life alterations in serotonin availability replicate some of the anatomical and behavioral abnormalities observed in autistic individuals. In recent years there has been a growing interest in the possible role of the hippocampus in autism. The aim of study is to examine the effects of neonatal antidepressant (CTM) exposure during a sensitive period of brain development on pyramidal and granule cells density of hippocampal formation. We examined the pyramidal and granular cells density of dorsal hippocampus using Nissl stained sections obtained from neonatal citalopram (CTM) exposed rats (5 mg/kg, twice daily, s.c.), from postnatal day 8 to 21 (PN8-21), saline and non-exposed rats. The density of pyramidal cells was significantly increased by 10.2 % in CA1, 10.6 % in CA3 and 13.2 % in CA4 in CTM treated compared with non-treated or saline treated animals (p<0.0001). The density of granule cells in the dentate gyrus was significantly increased by 12.0 % in CTM treated compared with non-treated or saline treated animals (p<0.0001). These findings were obtained only from male rats, suggesting a sexual dimorphism in neural development after SSRI exposure. These data suggest that the neonatal exposure to CTM may induce long-lasting changes in the hippcampal formation in adults, and such effects appear to preferentially target males.
author	Kalbouneh,Heba M Alzghoul,Loai A
author_facet	Kalbouneh,Heba M Alzghoul,Loai A
author_sort	Kalbouneh,Heba M
title	Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
title_short	Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
title_full	Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
title_fullStr	Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
title_full_unstemmed	Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study
title_sort	neonatal exposure to citalopram increases pyramidal and granular cell density in dorsal hippocampus of male but not female adult rats: a quantitative nissl study
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200576
work_keys_str_mv	AT kalbounehhebam neonatalexposuretocitalopramincreasespyramidalandgranularcelldensityindorsalhippocampusofmalebutnotfemaleadultratsaquantitativenisslstudy AT alzghoulloaia neonatalexposuretocitalopramincreasespyramidalandgranularcelldensityindorsalhippocampusofmalebutnotfemaleadultratsaquantitativenisslstudy
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Neonatal Exposure to Citalopram Increases Pyramidal and Granular Cell Density in Dorsal Hippocampus of Male but not Female Adult Rats: A Quantitative Nissl Study

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