Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp

SUMMARY: The purpose of this study was to examine the expression levels of the dental pulp to elucidate the role of Vascular Endothelial Growth Factor (VEGF) and CD68 on vascular angiogenesis, inflammation and odontoblast differentiation in the pulp tissue of diabetic rats depending on the effect of...

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Autores principales:	Uysal,Ibrahim, Gokalp-Ozkorkmaz,Ebru, Deveci,Engin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	VEGF CD68 Diabetes mellitus Teeth Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200606
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spelling	oai:scielo:S0717-950220190002006062019-09-11Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth PulpUysal,IbrahimGokalp-Ozkorkmaz,EbruDeveci,Engin VEGF CD68 Diabetes mellitus Teeth Rat SUMMARY: The purpose of this study was to examine the expression levels of the dental pulp to elucidate the role of Vascular Endothelial Growth Factor (VEGF) and CD68 on vascular angiogenesis, inflammation and odontoblast differentiation in the pulp tissue of diabetic rats depending on the effect of possible damage induced by diabetes. Wistar rats were used in the study, divided into two groups. Control group was fed with standard rat chow and drinking water ad libitum for 8 weeks. Single dose of streptozotocin (STZ) (55 mg/kg), was disolved in sodium citrate buffer and administered by intraperitoneal injection. Blood glucose concentration of rats exceeding 250 mg/dl were accepted as diabetic. Rats were sacrificed under anesthesia. Tissues were immediately dissected, fixed and embedded in paraffin and cut with a microtome then examined under light microscope. In the cross-sections of pulp tissue of diabetic group; the dilation of blood vessels besides hemorrhage and a significant increase in inflammatory cells were seen. The expression of VEGF in the blood vessel endothelial cells of the pulp was increased. VEGF showed positive reaction for degenerative odontoblast cells in the pulp. In this study, increase in VEGF and CD68 expressions in pulp tissue due to the effect of diabetes was thought to delay pulp treatment by inducing soft tissue damage and hypoxia.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.2 20192019-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200606en10.4067/S0717-95022019000200606
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	VEGF CD68 Diabetes mellitus Teeth Rat
spellingShingle	VEGF CD68 Diabetes mellitus Teeth Rat Uysal,Ibrahim Gokalp-Ozkorkmaz,Ebru Deveci,Engin Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
description	SUMMARY: The purpose of this study was to examine the expression levels of the dental pulp to elucidate the role of Vascular Endothelial Growth Factor (VEGF) and CD68 on vascular angiogenesis, inflammation and odontoblast differentiation in the pulp tissue of diabetic rats depending on the effect of possible damage induced by diabetes. Wistar rats were used in the study, divided into two groups. Control group was fed with standard rat chow and drinking water ad libitum for 8 weeks. Single dose of streptozotocin (STZ) (55 mg/kg), was disolved in sodium citrate buffer and administered by intraperitoneal injection. Blood glucose concentration of rats exceeding 250 mg/dl were accepted as diabetic. Rats were sacrificed under anesthesia. Tissues were immediately dissected, fixed and embedded in paraffin and cut with a microtome then examined under light microscope. In the cross-sections of pulp tissue of diabetic group; the dilation of blood vessels besides hemorrhage and a significant increase in inflammatory cells were seen. The expression of VEGF in the blood vessel endothelial cells of the pulp was increased. VEGF showed positive reaction for degenerative odontoblast cells in the pulp. In this study, increase in VEGF and CD68 expressions in pulp tissue due to the effect of diabetes was thought to delay pulp treatment by inducing soft tissue damage and hypoxia.
author	Uysal,Ibrahim Gokalp-Ozkorkmaz,Ebru Deveci,Engin
author_facet	Uysal,Ibrahim Gokalp-Ozkorkmaz,Ebru Deveci,Engin
author_sort	Uysal,Ibrahim
title	Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
title_short	Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
title_full	Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
title_fullStr	Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
title_full_unstemmed	Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
title_sort	experimentally induced diabetes mellitus influences expression of vegf and cd68 in rat teeth pulp
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000200606
work_keys_str_mv	AT uysalibrahim experimentallyinduceddiabetesmellitusinfluencesexpressionofvegfandcd68inratteethpulp AT gokalpozkorkmazebru experimentallyinduceddiabetesmellitusinfluencesexpressionofvegfandcd68inratteethpulp AT deveciengin experimentallyinduceddiabetesmellitusinfluencesexpressionofvegfandcd68inratteethpulp
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Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp

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