The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection

SUMMARY: Intermittent fasting diet (IF) as a restrictive regimen prevents neural degeneration and stimulates overexpression of various neurotropic factors in the hippocampus of animal models. This study evaluates the potential effect of the IF in the prevention of learning and memory dysfunction and...

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Autores principales:	Hassanpour,Azam, Hassanpour,Ashraf, Rezvani,Mohammad Ebrahim, Hosseini-Sharifabad,Mohamad, Basiri,Mohsen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Intermittent fasting diet Hippocampus Demyelination Stereology Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300805
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spelling	oai:scielo:S0717-950220190003008052019-09-11The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide InjectionHassanpour,AzamHassanpour,AshrafRezvani,Mohammad EbrahimHosseini-Sharifabad,MohamadBasiri,Mohsen Intermittent fasting diet Hippocampus Demyelination Stereology Mice SUMMARY: Intermittent fasting diet (IF) as a restrictive regimen prevents neural degeneration and stimulates overexpression of various neurotropic factors in the hippocampus of animal models. This study evaluates the potential effect of the IF in the prevention of learning and memory dysfunction and improving the alterations in the number and volume of neurons in an ethidium bromide (EB) induced mouse model of demyelination.Mice were randomly assigned into N group (Normal Diet and normal saline injection), F group (IF and normal saline injection), EBN group (Normal Diet and EB injection), EBF group (IF and EB injection). The hidden platform test was carried out based on path length, escape latency and swim speeds of mice. Stereological studies were determined by the Cavalieri and the Optical Dissector technique. Maintenance of mice on the IF results in significantly decreased the body weight and biochemical parameters, increased total number of neurons and volume of the hippocampus, and improved learning and memory parameters of adult male mice. However, IF in EBF group did not show as excellently as F group. The EBF group displayed significantly spatial memory improvement than that in EBN group. There were no statistically significant differences between EBF and EBN groups in stereological and learning parameters, though the EBF group displayed faster escape latencies, and swam faster and shorter path lengths than the EBN group in these parameters. Therefore as a conclusion, The IF fairly improved some adverse effects of EB in experimental demyelination models.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300805en10.4067/S0717-95022019000300805
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Intermittent fasting diet Hippocampus Demyelination Stereology Mice
spellingShingle	Intermittent fasting diet Hippocampus Demyelination Stereology Mice Hassanpour,Azam Hassanpour,Ashraf Rezvani,Mohammad Ebrahim Hosseini-Sharifabad,Mohamad Basiri,Mohsen The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
description	SUMMARY: Intermittent fasting diet (IF) as a restrictive regimen prevents neural degeneration and stimulates overexpression of various neurotropic factors in the hippocampus of animal models. This study evaluates the potential effect of the IF in the prevention of learning and memory dysfunction and improving the alterations in the number and volume of neurons in an ethidium bromide (EB) induced mouse model of demyelination.Mice were randomly assigned into N group (Normal Diet and normal saline injection), F group (IF and normal saline injection), EBN group (Normal Diet and EB injection), EBF group (IF and EB injection). The hidden platform test was carried out based on path length, escape latency and swim speeds of mice. Stereological studies were determined by the Cavalieri and the Optical Dissector technique. Maintenance of mice on the IF results in significantly decreased the body weight and biochemical parameters, increased total number of neurons and volume of the hippocampus, and improved learning and memory parameters of adult male mice. However, IF in EBF group did not show as excellently as F group. The EBF group displayed significantly spatial memory improvement than that in EBN group. There were no statistically significant differences between EBF and EBN groups in stereological and learning parameters, though the EBF group displayed faster escape latencies, and swam faster and shorter path lengths than the EBN group in these parameters. Therefore as a conclusion, The IF fairly improved some adverse effects of EB in experimental demyelination models.
author	Hassanpour,Azam Hassanpour,Ashraf Rezvani,Mohammad Ebrahim Hosseini-Sharifabad,Mohamad Basiri,Mohsen
author_facet	Hassanpour,Azam Hassanpour,Ashraf Rezvani,Mohammad Ebrahim Hosseini-Sharifabad,Mohamad Basiri,Mohsen
author_sort	Hassanpour,Azam
title	The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
title_short	The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
title_full	The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
title_fullStr	The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
title_full_unstemmed	The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection
title_sort	effect of intermittent fasting diet on the hippocampus of adult male mouse after inducing demyelination by ethidium bromide injection
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300805
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The Effect of Intermittent Fasting Diet on the Hippocampus of Adult Male Mouse After Inducing Demyelination by Ethidium Bromide Injection

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