Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats

SUMMARY: One of the key functions of the hepatobiliary system is bile formation. Aquaporins (AQPs) are likely to play a role in water transport that is essential for appropriate hepatobiliary tract function. The increasing prevalence of fatty liver parallels the rise of obesity and its complications...

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Autores principales:	Wang,Jinbao, Wang,Pei, Yang,Wen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Obesity Liver AQP1 Fatty liver
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300815
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spelling	oai:scielo:S0717-950220190003008152019-09-11Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet RatsWang,JinbaoWang,PeiYang,Wen Obesity Liver AQP1 Fatty liver SUMMARY: One of the key functions of the hepatobiliary system is bile formation. Aquaporins (AQPs) are likely to play a role in water transport that is essential for appropriate hepatobiliary tract function. The increasing prevalence of fatty liver parallels the rise of obesity and its complications over the past several decades. In this paper, general morphology observation, histopathology and AQP1 immunohistochemical expression were observed in livers of the high-fat diet (HFD) rats. For the liver of HFD rats, immunolight microscopy revealed weak labeling of AQP1 on the surface of central veins and liver sinusoid compared with the normal diet (ND) rats. It was suggested that bile secreted by the liver of HFD rats was maybe abnormal, thereby causing abnormalities in the composition and secretion of bile. However, the deeper understanding of mechanisms involved to the fatty liver is still unclear, in particular AQPs in the liver of obesity, additional studies would be required to study the signalling cascades involved in these processes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300815en10.4067/S0717-95022019000300815
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Obesity Liver AQP1 Fatty liver
spellingShingle	Obesity Liver AQP1 Fatty liver Wang,Jinbao Wang,Pei Yang,Wen Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
description	SUMMARY: One of the key functions of the hepatobiliary system is bile formation. Aquaporins (AQPs) are likely to play a role in water transport that is essential for appropriate hepatobiliary tract function. The increasing prevalence of fatty liver parallels the rise of obesity and its complications over the past several decades. In this paper, general morphology observation, histopathology and AQP1 immunohistochemical expression were observed in livers of the high-fat diet (HFD) rats. For the liver of HFD rats, immunolight microscopy revealed weak labeling of AQP1 on the surface of central veins and liver sinusoid compared with the normal diet (ND) rats. It was suggested that bile secreted by the liver of HFD rats was maybe abnormal, thereby causing abnormalities in the composition and secretion of bile. However, the deeper understanding of mechanisms involved to the fatty liver is still unclear, in particular AQPs in the liver of obesity, additional studies would be required to study the signalling cascades involved in these processes.
author	Wang,Jinbao Wang,Pei Yang,Wen
author_facet	Wang,Jinbao Wang,Pei Yang,Wen
author_sort	Wang,Jinbao
title	Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
title_short	Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
title_full	Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
title_fullStr	Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
title_full_unstemmed	Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats
title_sort	immunohistochemical identification of aqp1 in livers of the high-fat diet rats
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300815
work_keys_str_mv	AT wangjinbao immunohistochemicalidentificationofaqp1inliversofthehighfatdietrats AT wangpei immunohistochemicalidentificationofaqp1inliversofthehighfatdietrats AT yangwen immunohistochemicalidentificationofaqp1inliversofthehighfatdietrats
_version_	1718445105528963072

Immunohistochemical Identification of AQP1 in Livers of the High-fat Diet Rats

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