A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period

SUMMARY: The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar albino rats were used and divided into 5 main groups. Group Ia served...

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Autores principales:	Mustafa,Hesham N, Alkan,Isinsu, Deniz,Ömür Gülsüm, Altunkaynak,Berrin Zuhal, Annaç,Ebru, Kaplan,Suleyman
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Diclofenac sodium Proximal convoluted tubules Apoptosis Cyclooxygenase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300877
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spelling	oai:scielo:S0717-950220190003008772019-09-11A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal PeriodMustafa,Hesham NAlkan,IsinsuDeniz,Ömür GülsümAltunkaynak,Berrin ZuhalAnnaç,EbruKaplan,Suleyman Diclofenac sodium Proximal convoluted tubules Apoptosis Cyclooxygenase SUMMARY: The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar albino rats were used and divided into 5 main groups. Group Ia served as normal control, physiologic group Ib received normal saline, group II received low dose (3.9 mg/kg), group III received medium dose (9 mg/kg) and group IV received high dose (18 mg/kg). Male offspring’s from 0-7 days after birth were used in this study. On the 8th day of postnatal life, all animals were anesthetized. Then, the kidney samples were analyzed. Haematoxylin and eosin staining showed degeneration and necrosis, apparent atrophy of the glomeruli, mononuclear cell infiltration, congested vessels, increased fibrous tissue and distortion of the proximal convoluted tubules with interruption of the brush margin of the DS treated group. Increased level of Caspase-3 and upregulation of TNF-α with different doses of DS. In light of our findings, DS may lead to adverse effects that are dose-dependent in the prenatal subjected kidney to this drug.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300877en10.4067/S0717-95022019000300877
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diclofenac sodium Proximal convoluted tubules Apoptosis Cyclooxygenase
spellingShingle	Diclofenac sodium Proximal convoluted tubules Apoptosis Cyclooxygenase Mustafa,Hesham N Alkan,Isinsu Deniz,Ömür Gülsüm Altunkaynak,Berrin Zuhal Annaç,Ebru Kaplan,Suleyman A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
description	SUMMARY: The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar albino rats were used and divided into 5 main groups. Group Ia served as normal control, physiologic group Ib received normal saline, group II received low dose (3.9 mg/kg), group III received medium dose (9 mg/kg) and group IV received high dose (18 mg/kg). Male offspring’s from 0-7 days after birth were used in this study. On the 8th day of postnatal life, all animals were anesthetized. Then, the kidney samples were analyzed. Haematoxylin and eosin staining showed degeneration and necrosis, apparent atrophy of the glomeruli, mononuclear cell infiltration, congested vessels, increased fibrous tissue and distortion of the proximal convoluted tubules with interruption of the brush margin of the DS treated group. Increased level of Caspase-3 and upregulation of TNF-α with different doses of DS. In light of our findings, DS may lead to adverse effects that are dose-dependent in the prenatal subjected kidney to this drug.
author	Mustafa,Hesham N Alkan,Isinsu Deniz,Ömür Gülsüm Altunkaynak,Berrin Zuhal Annaç,Ebru Kaplan,Suleyman
author_facet	Mustafa,Hesham N Alkan,Isinsu Deniz,Ömür Gülsüm Altunkaynak,Berrin Zuhal Annaç,Ebru Kaplan,Suleyman
author_sort	Mustafa,Hesham N
title	A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
title_short	A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
title_full	A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
title_fullStr	A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
title_full_unstemmed	A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period
title_sort	study on the toxic effect of different doses of diclofenac sodium on the development of the kidney in the postnatal period
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000300877
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A Study on the Toxic Effect of Different Doses of Diclofenac Sodium on the Development of the Kidney in the Postnatal Period

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