Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investiga...

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Autores principales:	Al-Doaiss,Amin A, Ali,Daoud, Ali,Bahy A, Jarrar,Bashir M
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	TiO2 nanoparticles Renal tissues Histological alterations Hydropic degeneration Nanotoxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301049
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spelling	oai:scielo:S0717-950220190003010492019-09-11Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide NanoparticlesAl-Doaiss,Amin AAli,DaoudAli,Bahy AJarrar,Bashir M TiO2 nanoparticles Renal tissues Histological alterations Hydropic degeneration Nanotoxicity SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate the renal damage that might be induced by the acute toxicity TiO2 NPs. A total of 40 healthy male adult Wistar albino rats (Rattus norvegicus) were exposed to TiO2 NPs (126, 252, 378 mg/kg bw) for 24 and 48 h. Fresh portions of the kidneys from each rat were processed for histological and histochemical alterations. In comparison with respective control rats, exposure to TiO2 NPs has marked the following glomerular, tubular and interstitial alterations including the followings: glomerular congestion, Bowman's capsule swelling and dilatation, inflamed glomeruli, renal tubules cloudy swelling, karyorrhexis, karyolysis, infiltration of inflammatory cells, congestion, necrosis, hydropic degeneration, dilatation and congestion of blood vessels, hyaline droplets and hyaline casts precipitation, interstitial edema and fibrosis. From the findings of the current work one may conclude that TiO2 NPs are capable of inducing kidney damage with more insulation in the cortex and the proximal convoluted tubules than the medulla and the distal ones respectively. In addition, it might be concluded that renal damage induced by these nanomaterials is dose and duration of exposure dependent. Further hematological, biochemical, immunohistochemical, and ultra-structural studies are recommended.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301049en10.4067/S0717-95022019000301049
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	TiO2 nanoparticles Renal tissues Histological alterations Hydropic degeneration Nanotoxicity
spellingShingle	TiO2 nanoparticles Renal tissues Histological alterations Hydropic degeneration Nanotoxicity Al-Doaiss,Amin A Ali,Daoud Ali,Bahy A Jarrar,Bashir M Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
description	SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate the renal damage that might be induced by the acute toxicity TiO2 NPs. A total of 40 healthy male adult Wistar albino rats (Rattus norvegicus) were exposed to TiO2 NPs (126, 252, 378 mg/kg bw) for 24 and 48 h. Fresh portions of the kidneys from each rat were processed for histological and histochemical alterations. In comparison with respective control rats, exposure to TiO2 NPs has marked the following glomerular, tubular and interstitial alterations including the followings: glomerular congestion, Bowman's capsule swelling and dilatation, inflamed glomeruli, renal tubules cloudy swelling, karyorrhexis, karyolysis, infiltration of inflammatory cells, congestion, necrosis, hydropic degeneration, dilatation and congestion of blood vessels, hyaline droplets and hyaline casts precipitation, interstitial edema and fibrosis. From the findings of the current work one may conclude that TiO2 NPs are capable of inducing kidney damage with more insulation in the cortex and the proximal convoluted tubules than the medulla and the distal ones respectively. In addition, it might be concluded that renal damage induced by these nanomaterials is dose and duration of exposure dependent. Further hematological, biochemical, immunohistochemical, and ultra-structural studies are recommended.
author	Al-Doaiss,Amin A Ali,Daoud Ali,Bahy A Jarrar,Bashir M
author_facet	Al-Doaiss,Amin A Ali,Daoud Ali,Bahy A Jarrar,Bashir M
author_sort	Al-Doaiss,Amin A
title	Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
title_short	Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
title_full	Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
title_fullStr	Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
title_full_unstemmed	Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles
title_sort	renal histological alterations induced by acute exposure of titanium dioxide nanoparticles
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301049
work_keys_str_mv	AT aldoaissamina renalhistologicalalterationsinducedbyacuteexposureoftitaniumdioxidenanoparticles AT alidaoud renalhistologicalalterationsinducedbyacuteexposureoftitaniumdioxidenanoparticles AT alibahya renalhistologicalalterationsinducedbyacuteexposureoftitaniumdioxidenanoparticles AT jarrarbashirm renalhistologicalalterationsinducedbyacuteexposureoftitaniumdioxidenanoparticles
_version_	1718445112236703744

Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

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