Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure

SUMMARY: We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention: The first group (control): healthy rats without any injuries and experimental group: rats wit...

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Autores principales:	Raoofi,Amir, Gharibian,Saeed, Sadeghi,Yousef
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Degenerative Anterior horn of spinal cord Stereology Axotomy Motor functional
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301101
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spelling	oai:scielo:S0717-950220190003011012019-09-11Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord StructureRaoofi,AmirGharibian,SaeedSadeghi,Yousef Degenerative Anterior horn of spinal cord Stereology Axotomy Motor functional SUMMARY: We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention: The first group (control): healthy rats without any injuries and experimental group: rats with injured sciatic nerve without treatment. at 12 weeks, the L4 and L5 spinal cord segments were removed. We evaluated nerve function using muscle electromyography (EMG) activity and sciatic function index (SFI) simultaneously with histological spinal cord analyses by stereological methods at 12 week. After nerve injury presented gross locomotor deficits at week 12. We also found that the volume of the anterior horn of spinal cord and total number of motor neurons were decreased after nerve axotomy (p<0.05). In conjunction, these results indicate that peripheral nerve injuries have more severe consequences on hind limb motor output.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301101en10.4067/S0717-95022019000301101
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Degenerative Anterior horn of spinal cord Stereology Axotomy Motor functional
spellingShingle	Degenerative Anterior horn of spinal cord Stereology Axotomy Motor functional Raoofi,Amir Gharibian,Saeed Sadeghi,Yousef Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
description	SUMMARY: We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention: The first group (control): healthy rats without any injuries and experimental group: rats with injured sciatic nerve without treatment. at 12 weeks, the L4 and L5 spinal cord segments were removed. We evaluated nerve function using muscle electromyography (EMG) activity and sciatic function index (SFI) simultaneously with histological spinal cord analyses by stereological methods at 12 week. After nerve injury presented gross locomotor deficits at week 12. We also found that the volume of the anterior horn of spinal cord and total number of motor neurons were decreased after nerve axotomy (p<0.05). In conjunction, these results indicate that peripheral nerve injuries have more severe consequences on hind limb motor output.
author	Raoofi,Amir Gharibian,Saeed Sadeghi,Yousef
author_facet	Raoofi,Amir Gharibian,Saeed Sadeghi,Yousef
author_sort	Raoofi,Amir
title	Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
title_short	Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
title_full	Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
title_fullStr	Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
title_full_unstemmed	Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure
title_sort	impairment induction by axotomy in motor functional and histological anterior horn of spinal cord structure
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000301101
work_keys_str_mv	AT raoofiamir impairmentinductionbyaxotomyinmotorfunctionalandhistologicalanteriorhornofspinalcordstructure AT gharibiansaeed impairmentinductionbyaxotomyinmotorfunctionalandhistologicalanteriorhornofspinalcordstructure AT sadeghiyousef impairmentinductionbyaxotomyinmotorfunctionalandhistologicalanteriorhornofspinalcordstructure
_version_	1718445113655427072

Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure

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