A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity

SUMMARY: In vitro modeling of neurodegenerative diseases is now possible by using patient-derived induced pluripotent stem cells (iPS). Through them, it is nowadays conceivable to obtain human neurons and glia, and study diseases cellular and molecular mechanisms, an attribute that was previously un...

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Autores principales:	Cáceres,D. E, Torres,F. C, Castillo,C. A, Maureira,A, Franco-Campos,F. A, Osorio,M, Segovia,R, Tapia,J. C, Carrasco,M. A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Motor neurons Amyotrophic Lateral Sclerosis (ALS) Induced pluripotent stem cells (iPS) Glia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401203
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spelling	oai:scielo:S0717-950220190004012032019-09-11A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons LongevityCáceres,D. ETorres,F. CCastillo,C. AMaureira,AFranco-Campos,F. AOsorio,MSegovia,RTapia,J. CCarrasco,M. A Motor neurons Amyotrophic Lateral Sclerosis (ALS) Induced pluripotent stem cells (iPS) Glia SUMMARY: In vitro modeling of neurodegenerative diseases is now possible by using patient-derived induced pluripotent stem cells (iPS). Through them, it is nowadays conceivable to obtain human neurons and glia, and study diseases cellular and molecular mechanisms, an attribute that was previously unavailable to any human condition. Amyotrophic lateral sclerosis (ALS) is one of the diseases that has gained a rapid advance with iPS technology. By differentiating motor neurons from iPS cells of ALS- patients, we are studying the mechanisms underlying ALS- disease onset and progression. Here, we introduce a cellular platform to help maintain longevity of ALS iPS-motor neurons, a cellular feature relevant for most late-onset human diseases. Long term cultures of patient-derived iPS cells might prove to be critical for the development of personalized-drugs.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.4 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401203en10.4067/S0717-95022019000401203
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Motor neurons Amyotrophic Lateral Sclerosis (ALS) Induced pluripotent stem cells (iPS) Glia
spellingShingle	Motor neurons Amyotrophic Lateral Sclerosis (ALS) Induced pluripotent stem cells (iPS) Glia Cáceres,D. E Torres,F. C Castillo,C. A Maureira,A Franco-Campos,F. A Osorio,M Segovia,R Tapia,J. C Carrasco,M. A A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
description	SUMMARY: In vitro modeling of neurodegenerative diseases is now possible by using patient-derived induced pluripotent stem cells (iPS). Through them, it is nowadays conceivable to obtain human neurons and glia, and study diseases cellular and molecular mechanisms, an attribute that was previously unavailable to any human condition. Amyotrophic lateral sclerosis (ALS) is one of the diseases that has gained a rapid advance with iPS technology. By differentiating motor neurons from iPS cells of ALS- patients, we are studying the mechanisms underlying ALS- disease onset and progression. Here, we introduce a cellular platform to help maintain longevity of ALS iPS-motor neurons, a cellular feature relevant for most late-onset human diseases. Long term cultures of patient-derived iPS cells might prove to be critical for the development of personalized-drugs.
author	Cáceres,D. E Torres,F. C Castillo,C. A Maureira,A Franco-Campos,F. A Osorio,M Segovia,R Tapia,J. C Carrasco,M. A
author_facet	Cáceres,D. E Torres,F. C Castillo,C. A Maureira,A Franco-Campos,F. A Osorio,M Segovia,R Tapia,J. C Carrasco,M. A
author_sort	Cáceres,D. E
title	A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
title_short	A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
title_full	A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
title_fullStr	A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
title_full_unstemmed	A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity
title_sort	platform to understand amyotrophic lateral sclerosis (als) and extend human motor neurons longevity
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401203
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A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity

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