Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats

Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats

SUMMARY: Impairing osteoporosis progression is a challenge, and recently the role of antioxidants has been associated to bone metabolism. Green tea extract is rich in catechins, especially epigallocatechin gallate (EGCG), which may help control osteoporosis damage in bone tissue. This investigation...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Freitas,Luana Cristina de, Sousa,Luiz Gustavo de, Leite,Guilherme Luciano, Scalize,Priscilla Hakime, Pitol,Dimitrius Leonardo, Righetti,Mariah Acioli, Ricardo,Vitória, Mello,Edneia Corrêa de, Bombonato-Prado,Karina Fittipaldi, Regalo,Simone Cecilio Hallak, Siessere,Selma
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2019
Materias:
Tea
Catechin
Osteoporosis
Bone
Rats
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401325
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0717-95022019000401325
record_format dspace
spelling oai:scielo:S0717-950220190004013252019-09-11Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized RatsFreitas,Luana Cristina deSousa,Luiz Gustavo deLeite,Guilherme LucianoScalize,Priscilla HakimePitol,Dimitrius LeonardoRighetti,Mariah AcioliRicardo,VitóriaMello,Edneia Corrêa deBombonato-Prado,Karina FittipaldiRegalo,Simone Cecilio HallakSiessere,Selma Tea Catechin Osteoporosis Bone Rats SUMMARY: Impairing osteoporosis progression is a challenge, and recently the role of antioxidants has been associated to bone metabolism. Green tea extract is rich in catechins, especially epigallocatechin gallate (EGCG), which may help control osteoporosis damage in bone tissue. This investigation evaluated the efficacy of green tea ingestion containing different concentrations of EGCG in calvaria bone repair of ovariectomized rats. Wistar rats (n=15) were ovariectomized and divided into 3 groups: ovariectomized (OVX), ovariectomized + GTE 15 % EGCG (OVX/GTE15), and ovariectomized + GTE 94 % EGCG (OVX/GTE94). Green tea extract was administered by gavage in the concentration of 50 mg/kg and sham group (n=5) received water. Bone defects were performed in the calvaria 60 days after ovariectomy followed by 4 weeks until euthanasia. Bone samples were collected to perform qualitative and quantitative histological analysis of bone formation. Data obtained were submitted to normality and ANOVA statistical test for p<0.05. The mean values of neoformed bone for Sham, OVX, OVX/GTE15 and OVX/GTE94 were respectively: 21.11 ± 3.91; 19.92 ± 2.20; 33.05 ± 1.26 e 34.75 ± 0.54 (p<0.05). Results show that continuous ingestion of green tea extract immediately after ovariectomy shows positive effects in the prevention of bone loss in osteoporosis, even with low concentrations of EGCG.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.4 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401325en10.4067/S0717-95022019000401325
institution Scielo Chile
collection Scielo Chile
language English
topic Tea
Catechin
Osteoporosis
Bone
Rats
spellingShingle Tea
Catechin
Osteoporosis
Bone
Rats
Freitas,Luana Cristina de
Sousa,Luiz Gustavo de
Leite,Guilherme Luciano
Scalize,Priscilla Hakime
Pitol,Dimitrius Leonardo
Righetti,Mariah Acioli
Ricardo,Vitória
Mello,Edneia Corrêa de
Bombonato-Prado,Karina Fittipaldi
Regalo,Simone Cecilio Hallak
Siessere,Selma
Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
description SUMMARY: Impairing osteoporosis progression is a challenge, and recently the role of antioxidants has been associated to bone metabolism. Green tea extract is rich in catechins, especially epigallocatechin gallate (EGCG), which may help control osteoporosis damage in bone tissue. This investigation evaluated the efficacy of green tea ingestion containing different concentrations of EGCG in calvaria bone repair of ovariectomized rats. Wistar rats (n=15) were ovariectomized and divided into 3 groups: ovariectomized (OVX), ovariectomized + GTE 15 % EGCG (OVX/GTE15), and ovariectomized + GTE 94 % EGCG (OVX/GTE94). Green tea extract was administered by gavage in the concentration of 50 mg/kg and sham group (n=5) received water. Bone defects were performed in the calvaria 60 days after ovariectomy followed by 4 weeks until euthanasia. Bone samples were collected to perform qualitative and quantitative histological analysis of bone formation. Data obtained were submitted to normality and ANOVA statistical test for p<0.05. The mean values of neoformed bone for Sham, OVX, OVX/GTE15 and OVX/GTE94 were respectively: 21.11 ± 3.91; 19.92 ± 2.20; 33.05 ± 1.26 e 34.75 ± 0.54 (p<0.05). Results show that continuous ingestion of green tea extract immediately after ovariectomy shows positive effects in the prevention of bone loss in osteoporosis, even with low concentrations of EGCG.
author Freitas,Luana Cristina de
Sousa,Luiz Gustavo de
Leite,Guilherme Luciano
Scalize,Priscilla Hakime
Pitol,Dimitrius Leonardo
Righetti,Mariah Acioli
Ricardo,Vitória
Mello,Edneia Corrêa de
Bombonato-Prado,Karina Fittipaldi
Regalo,Simone Cecilio Hallak
Siessere,Selma
author_facet Freitas,Luana Cristina de
Sousa,Luiz Gustavo de
Leite,Guilherme Luciano
Scalize,Priscilla Hakime
Pitol,Dimitrius Leonardo
Righetti,Mariah Acioli
Ricardo,Vitória
Mello,Edneia Corrêa de
Bombonato-Prado,Karina Fittipaldi
Regalo,Simone Cecilio Hallak
Siessere,Selma
author_sort Freitas,Luana Cristina de
title Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
title_short Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
title_full Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
title_fullStr Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
title_full_unstemmed Influence of Green Tea Extract with Different Concentrations of Epigallocatechin Gallate on Calvaria Bone Repair of Ovariectomized Rats
title_sort influence of green tea extract with different concentrations of epigallocatechin gallate on calvaria bone repair of ovariectomized rats
publisher Sociedad Chilena de Anatomía
publishDate 2019
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401325
work_keys_str_mv AT freitasluanacristinade influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT sousaluizgustavode influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT leiteguilhermeluciano influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT scalizepriscillahakime influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT pitoldimitriusleonardo influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT righettimariahacioli influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT ricardovitoria influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT melloedneiacorreade influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT bombonatopradokarinafittipaldi influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT regalosimonececiliohallak influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
AT siessereselma influenceofgreenteaextractwithdifferentconcentrationsofepigallocatechingallateoncalvariabonerepairofovariectomizedrats
_version_ 1718445120111509504

Ejemplares similares