Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue

SUMMARY: The indiscriminate use of anabolic steroids in gyms has been growing in a generalized way, among which, the most common is growth hormone (GH). In the short term GH may potentiate muscle growth, especially when taken in combination with resistance training. However, the effects of this horm...

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Autores principales:	Castoldi,Robson Chacon, Manganaro,Lincoln José, Ferreira,Soraia Carolline, Alves,Marcelo José, De-Carvalho-Filho,Carlos Augusto, Garcia,Thiago Alves, Ozaki,Guilherme Akio Tamura, Caetano,Heliard Rodrigues dos Santos, Zanuto,Éverton Alex Carvalho, Giometti,Inês Cristina, Camargo-Filho,José Carlos Silva
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2019
Materias:	Physical training Growth hormone Bone Femur Rats Collagen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401416
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spelling	oai:scielo:S0717-950220190004014162019-09-11Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone TissueCastoldi,Robson ChaconManganaro,Lincoln JoséFerreira,Soraia CarollineAlves,Marcelo JoséDe-Carvalho-Filho,Carlos AugustoGarcia,Thiago AlvesOzaki,Guilherme Akio TamuraCaetano,Heliard Rodrigues dos SantosZanuto,Éverton Alex CarvalhoGiometti,Inês CristinaCamargo-Filho,José Carlos Silva Physical training Growth hormone Bone Femur Rats Collagen SUMMARY: The indiscriminate use of anabolic steroids in gyms has been growing in a generalized way, among which, the most common is growth hormone (GH). In the short term GH may potentiate muscle growth, especially when taken in combination with resistance training. However, the effects of this hormone are not yet fully understood in the literature, especially in relation to collagen properties. The objective of this study was to evaluate the effect of the application of growth hormone (GH) and resistance training (RT) on the collagen properties of femoral bone tissue using Raman Spectroscopy. In this study 40 male rats were randomly distributed into four groups (n=10): control (C), control and GH application (GH), resistance training (T), and resistance training and GH application (GHT). The training consisted of four series of 10 water jumps, performed three times a week, with an overload corresponding to 50 % of body weight and duration of four weeks. GH was applied at a dosage of 0.2 IU/Kg (0.067 mg/kg) to each animal, three times a week, every other day. The animals were euthanized and the right femurs were collected for analysis of bone structure. Raman spectroscopy (RS) was used to observe the following compounds from their respective bands: type I collagen (662 cm-1), amide III (1243 cm-1), proteins including type I collagen (1278 cm-1), woven collagen (1322 cm-1), association of collagen, phospholipids, nucleic acid, and phosphate (1330 cm-1), and collagen and protein deformation (1448 cm-1). The results demonstrated an increase in the collagen properties in all analyzed variables, however, the T group presented a statistically significant difference (p<0.05). It is possible to conclude that isolated physical training was shown to be more efficient than when combined with the application of GH to increase the collagen properties of the femoral bone tissue.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.37 n.4 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401416en10.4067/S0717-95022019000401416
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Physical training Growth hormone Bone Femur Rats Collagen
spellingShingle	Physical training Growth hormone Bone Femur Rats Collagen Castoldi,Robson Chacon Manganaro,Lincoln José Ferreira,Soraia Carolline Alves,Marcelo José De-Carvalho-Filho,Carlos Augusto Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Caetano,Heliard Rodrigues dos Santos Zanuto,Éverton Alex Carvalho Giometti,Inês Cristina Camargo-Filho,José Carlos Silva Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
description	SUMMARY: The indiscriminate use of anabolic steroids in gyms has been growing in a generalized way, among which, the most common is growth hormone (GH). In the short term GH may potentiate muscle growth, especially when taken in combination with resistance training. However, the effects of this hormone are not yet fully understood in the literature, especially in relation to collagen properties. The objective of this study was to evaluate the effect of the application of growth hormone (GH) and resistance training (RT) on the collagen properties of femoral bone tissue using Raman Spectroscopy. In this study 40 male rats were randomly distributed into four groups (n=10): control (C), control and GH application (GH), resistance training (T), and resistance training and GH application (GHT). The training consisted of four series of 10 water jumps, performed three times a week, with an overload corresponding to 50 % of body weight and duration of four weeks. GH was applied at a dosage of 0.2 IU/Kg (0.067 mg/kg) to each animal, three times a week, every other day. The animals were euthanized and the right femurs were collected for analysis of bone structure. Raman spectroscopy (RS) was used to observe the following compounds from their respective bands: type I collagen (662 cm-1), amide III (1243 cm-1), proteins including type I collagen (1278 cm-1), woven collagen (1322 cm-1), association of collagen, phospholipids, nucleic acid, and phosphate (1330 cm-1), and collagen and protein deformation (1448 cm-1). The results demonstrated an increase in the collagen properties in all analyzed variables, however, the T group presented a statistically significant difference (p<0.05). It is possible to conclude that isolated physical training was shown to be more efficient than when combined with the application of GH to increase the collagen properties of the femoral bone tissue.
author	Castoldi,Robson Chacon Manganaro,Lincoln José Ferreira,Soraia Carolline Alves,Marcelo José De-Carvalho-Filho,Carlos Augusto Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Caetano,Heliard Rodrigues dos Santos Zanuto,Éverton Alex Carvalho Giometti,Inês Cristina Camargo-Filho,José Carlos Silva
author_facet	Castoldi,Robson Chacon Manganaro,Lincoln José Ferreira,Soraia Carolline Alves,Marcelo José De-Carvalho-Filho,Carlos Augusto Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Caetano,Heliard Rodrigues dos Santos Zanuto,Éverton Alex Carvalho Giometti,Inês Cristina Camargo-Filho,José Carlos Silva
author_sort	Castoldi,Robson Chacon
title	Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
title_short	Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
title_full	Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
title_fullStr	Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
title_full_unstemmed	Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue
title_sort	effect of growth hormone (gh) and resistance training on the collagen properties of femoral bone tissue
publisher	Sociedad Chilena de Anatomía
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022019000401416
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Effect of Growth Hormone (GH) and Resistance Training on the Collagen Properties of Femoral Bone Tissue

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