Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats

SUMMARY: This research was designed to investigate the potential protective effect of vitamin C supplementation against hepatocyte ultrastructural alterations induced by artemether (antimalarial drug) administration. Twenty-four adult male albino rats were used in this study and were divided into fo...

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Autores principales:	Eid,Refaat A, Zaki,Mohamed Samir Ahmed, Alghamdi,Mansour A, Sideeg,Abulqasim Mohammed, Ali,Kamal, Z. M, Andarawi,Mohamed, Haidara,Mohamed A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Artemether Rats Vitamin C Hepatocyte ultrastructure Biomarkers liver injury Oxidative stress
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100048
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spelling	oai:scielo:S0717-950220200001000482019-11-22Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in RatsEid,Refaat AZaki,Mohamed Samir AhmedAlghamdi,Mansour ASideeg,Abulqasim MohammedAli,Kamal, Z. MAndarawi,MohamedHaidara,Mohamed A Artemether Rats Vitamin C Hepatocyte ultrastructure Biomarkers liver injury Oxidative stress SUMMARY: This research was designed to investigate the potential protective effect of vitamin C supplementation against hepatocyte ultrastructural alterations induced by artemether (antimalarial drug) administration. Twenty-four adult male albino rats were used in this study and were divided into four groups (n=6). Group I served as a control and rats in group II administrated artemether (4 mg/kg B.W) orally for three consecutive days. Group III administered artemether plus a low dose of vitamin C (2.86 mg/kg/l water) while group IV received artemether plusa high dose of vitamin C (8.56 mg/kg). At the end of the experimental period (14 days), the harvested liver tissues were examined by transmission electron microscopy (TEM), and blood samples were assayed for biomarkers of liver injury and oxidative stress. Artemether significantly (p<0.05) augmented biomarkers of liver injury such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and oxidative stress such as superoxide dismutase (SOD), Glutathione Peroxidase (GPX), and caused degeneration and damage of the rough endoplasmic reticulum and disrupted mitochondria. The blood sinusoids were also damaged with distortion of their canaliculi. Administration of vitamin C showed improvement of liver biomarkers, and liver parenchyma, especially in a high dose of vitamin C.We concludes that vitamin C is a partial protective agent against artemether-induced liver injury.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100048en10.4067/S0717-95022020000100048
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Artemether Rats Vitamin C Hepatocyte ultrastructure Biomarkers liver injury Oxidative stress
spellingShingle	Artemether Rats Vitamin C Hepatocyte ultrastructure Biomarkers liver injury Oxidative stress Eid,Refaat A Zaki,Mohamed Samir Ahmed Alghamdi,Mansour A Sideeg,Abulqasim Mohammed Ali,Kamal, Z. M Andarawi,Mohamed Haidara,Mohamed A Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
description	SUMMARY: This research was designed to investigate the potential protective effect of vitamin C supplementation against hepatocyte ultrastructural alterations induced by artemether (antimalarial drug) administration. Twenty-four adult male albino rats were used in this study and were divided into four groups (n=6). Group I served as a control and rats in group II administrated artemether (4 mg/kg B.W) orally for three consecutive days. Group III administered artemether plus a low dose of vitamin C (2.86 mg/kg/l water) while group IV received artemether plusa high dose of vitamin C (8.56 mg/kg). At the end of the experimental period (14 days), the harvested liver tissues were examined by transmission electron microscopy (TEM), and blood samples were assayed for biomarkers of liver injury and oxidative stress. Artemether significantly (p<0.05) augmented biomarkers of liver injury such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and oxidative stress such as superoxide dismutase (SOD), Glutathione Peroxidase (GPX), and caused degeneration and damage of the rough endoplasmic reticulum and disrupted mitochondria. The blood sinusoids were also damaged with distortion of their canaliculi. Administration of vitamin C showed improvement of liver biomarkers, and liver parenchyma, especially in a high dose of vitamin C.We concludes that vitamin C is a partial protective agent against artemether-induced liver injury.
author	Eid,Refaat A Zaki,Mohamed Samir Ahmed Alghamdi,Mansour A Sideeg,Abulqasim Mohammed Ali,Kamal, Z. M Andarawi,Mohamed Haidara,Mohamed A
author_facet	Eid,Refaat A Zaki,Mohamed Samir Ahmed Alghamdi,Mansour A Sideeg,Abulqasim Mohammed Ali,Kamal, Z. M Andarawi,Mohamed Haidara,Mohamed A
author_sort	Eid,Refaat A
title	Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
title_short	Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
title_full	Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
title_fullStr	Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
title_full_unstemmed	Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats
title_sort	vitamin c administration attenuated artemether induced hepatic injury in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100048
work_keys_str_mv	AT eidrefaata vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT zakimohamedsamirahmed vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT alghamdimansoura vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT sideegabulqasimmohammed vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT alikamalzm vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT andarawimohamed vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats AT haidaramohameda vitamincadministrationattenuatedartemetherinducedhepaticinjuryinrats
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Vitamin C Administration Attenuated Artemether Induced Hepatic Injury in Rats

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