High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats

SUMMARY: Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomar...

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Autores principales:	El-Bidawy,Mahmoud H, Bastawy,Nermeen, Mansour-Khalifa,Mohamed, Abdulla,Hanan, Elsayed,Rania, Rashed,Laila, Niazy,Marwa, Al-Ghamdi,Sameer, Haidara,Mohamed A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Ovariectomy Menopause Inflammation NF-kB, Dyslipidemia Rat model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100129
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spelling	oai:scielo:S0717-950220200001001292019-11-22High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in RatsEl-Bidawy,Mahmoud HBastawy,NermeenMansour-Khalifa,MohamedAbdulla,HananElsayed,RaniaRashed,LailaNiazy,MarwaAl-Ghamdi,SameerHaidara,Mohamed A Ovariectomy Menopause Inflammation NF-kB, Dyslipidemia Rat model SUMMARY: Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100129en10.4067/S0717-95022020000100129
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ovariectomy Menopause Inflammation NF-kB, Dyslipidemia Rat model
spellingShingle	Ovariectomy Menopause Inflammation NF-kB, Dyslipidemia Rat model El-Bidawy,Mahmoud H Bastawy,Nermeen Mansour-Khalifa,Mohamed Abdulla,Hanan Elsayed,Rania Rashed,Laila Niazy,Marwa Al-Ghamdi,Sameer Haidara,Mohamed A High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
description	SUMMARY: Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.
author	El-Bidawy,Mahmoud H Bastawy,Nermeen Mansour-Khalifa,Mohamed Abdulla,Hanan Elsayed,Rania Rashed,Laila Niazy,Marwa Al-Ghamdi,Sameer Haidara,Mohamed A
author_facet	El-Bidawy,Mahmoud H Bastawy,Nermeen Mansour-Khalifa,Mohamed Abdulla,Hanan Elsayed,Rania Rashed,Laila Niazy,Marwa Al-Ghamdi,Sameer Haidara,Mohamed A
author_sort	El-Bidawy,Mahmoud H
title	High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
title_short	High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
title_full	High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
title_fullStr	High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
title_full_unstemmed	High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats
title_sort	high-fat diet augments ovariectomy-induced bone resorption in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100129
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High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats

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