Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium

SUMMARY: An alternative hyper-ovulator inducer to replace clomiphene citrate (CC) is needed as it is unsuitable for women with polycystic ovarian syndrome and is associated with low pregnancy rates. Anastrozole is an effective hyper-ovulator inducer, but has not been well researched. In order to det...

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Autores principales:	Mwakikunga,Anthony, Adefolaju,Gbenga A, Schepartz,Lynne, Hosie,Margot J
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Implantation Uterus Early pregnancy Paxillin FAK Focal adhesion proteins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100165
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spelling	oai:scielo:S0717-950220200001001652019-11-22Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine EpitheliumMwakikunga,AnthonyAdefolaju,Gbenga ASchepartz,LynneHosie,Margot J Implantation Uterus Early pregnancy Paxillin FAK Focal adhesion proteins SUMMARY: An alternative hyper-ovulator inducer to replace clomiphene citrate (CC) is needed as it is unsuitable for women with polycystic ovarian syndrome and is associated with low pregnancy rates. Anastrozole is an effective hyper-ovulator inducer, but has not been well researched. In order to determine the effectiveness of anastrozole as a hyper-ovulator inducer and to an extent compare it with CC in similar situations, this study ascertained the effects of these drugs on the expression of the focal adhesion proteins, paxillin and FAK, which are uterine receptivity markers in the surface luminal uterine epithelial cells of day 1 and day 6 pregnant Wistar rats. The results show that paxillin is localized in focal adhesions at the base of the uterine epithelial cells at day 1 of pregnancy whereas at day 6, paxillin disassembles from the basal focal adhesions and localizes and increases its expression apically. FAK is faintly expressed at the basal aspect of the uterine epithelial cells while moderately expressed at the cell-to-cell contact at day 1 in all groups from where it disassembles and relocates apically and becomes more intensely expressed at day 6 of pregnancy in untreated and anastrozole treated rats. Although paxillin is localized apically at day 6, its expression is significantly down-regulated with CC treatment suggesting its interference with the implantation process. These findings seem to suggest that anastrozole could favor implantation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100165en10.4067/S0717-95022020000100165
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Implantation Uterus Early pregnancy Paxillin FAK Focal adhesion proteins
spellingShingle	Implantation Uterus Early pregnancy Paxillin FAK Focal adhesion proteins Mwakikunga,Anthony Adefolaju,Gbenga A Schepartz,Lynne Hosie,Margot J Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
description	SUMMARY: An alternative hyper-ovulator inducer to replace clomiphene citrate (CC) is needed as it is unsuitable for women with polycystic ovarian syndrome and is associated with low pregnancy rates. Anastrozole is an effective hyper-ovulator inducer, but has not been well researched. In order to determine the effectiveness of anastrozole as a hyper-ovulator inducer and to an extent compare it with CC in similar situations, this study ascertained the effects of these drugs on the expression of the focal adhesion proteins, paxillin and FAK, which are uterine receptivity markers in the surface luminal uterine epithelial cells of day 1 and day 6 pregnant Wistar rats. The results show that paxillin is localized in focal adhesions at the base of the uterine epithelial cells at day 1 of pregnancy whereas at day 6, paxillin disassembles from the basal focal adhesions and localizes and increases its expression apically. FAK is faintly expressed at the basal aspect of the uterine epithelial cells while moderately expressed at the cell-to-cell contact at day 1 in all groups from where it disassembles and relocates apically and becomes more intensely expressed at day 6 of pregnancy in untreated and anastrozole treated rats. Although paxillin is localized apically at day 6, its expression is significantly down-regulated with CC treatment suggesting its interference with the implantation process. These findings seem to suggest that anastrozole could favor implantation.
author	Mwakikunga,Anthony Adefolaju,Gbenga A Schepartz,Lynne Hosie,Margot J
author_facet	Mwakikunga,Anthony Adefolaju,Gbenga A Schepartz,Lynne Hosie,Margot J
author_sort	Mwakikunga,Anthony
title	Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
title_short	Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
title_full	Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
title_fullStr	Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
title_full_unstemmed	Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium
title_sort	anastrozole promotes implantation by altering the expression of paxillin and fak in rat luminal uterine epithelium
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100165
work_keys_str_mv	AT mwakikungaanthony anastrozolepromotesimplantationbyalteringtheexpressionofpaxillinandfakinratluminaluterineepithelium AT adefolajugbengaa anastrozolepromotesimplantationbyalteringtheexpressionofpaxillinandfakinratluminaluterineepithelium AT schepartzlynne anastrozolepromotesimplantationbyalteringtheexpressionofpaxillinandfakinratluminaluterineepithelium AT hosiemargotj anastrozolepromotesimplantationbyalteringtheexpressionofpaxillinandfakinratluminaluterineepithelium
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Anastrozole Promotes Implantation by Altering the Expression of Paxillin and FAK in Rat Luminal Uterine Epithelium

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