Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)

SUMMARY: As a result of their intense physical activity, racehorses suffer high tendon stress which may result in various pathologies. One of these is tendonitis in the tendon of the superficial digital flexor muscle (TSDFM). Conventional treatment with rest, has not shown to be very effective, and...

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Autores principales:	Rivera,Christopher, Tuemmers,Christian, Bañados,Rodrigo, Vidal-Seguel,Nicolás, Montiel-Eulefi,Enrique
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Horse MSC Regenerative medicine TSDFM
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100186
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spelling	oai:scielo:S0717-950220200001001862019-11-22Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)Rivera,ChristopherTuemmers,ChristianBañados,RodrigoVidal-Seguel,NicolásMontiel-Eulefi,Enrique Horse MSC Regenerative medicine TSDFM SUMMARY: As a result of their intense physical activity, racehorses suffer high tendon stress which may result in various pathologies. One of these is tendonitis in the tendon of the superficial digital flexor muscle (TSDFM). Conventional treatment with rest, has not shown to be very effective, and regenerative medicine through the application mesenchymal stem cells appears to be a promising therapy. The objective of this work was to assess the effect of the application of autologous MSC on reduction of the scar length in recurrent TSDFM tendinitis in Holsteiner horses, using image analysis. This study included two groups of five animals each: A control group that received conventional treatment (CG) and an experimental group which was also treated with intralesional injections of MSC (EG). Scar evolution was assessed by echographic analysis, with measurements taken of the scar length over a four month period; the length at month zero, was taken as the initial value of 100 %. During the first month, the mean scar length diminished to 81.14 % (EG) and 95.85 % (CG); after the second month, lengths were 64.4 % (EG) and 92.3 % (CG); following the third month lengths were 51.92 % (EG) and 87.42 % (CG); finally at the end of the fourth month the lengths recorded were 26.7 % (EG) and 83.92 % (CG). These results show that treatment with autologous MSC helps TSDFM scar length was significantly reduced, as compared to conventional treatment.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100186en10.4067/S0717-95022020000100186
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Horse MSC Regenerative medicine TSDFM
spellingShingle	Horse MSC Regenerative medicine TSDFM Rivera,Christopher Tuemmers,Christian Bañados,Rodrigo Vidal-Seguel,Nicolás Montiel-Eulefi,Enrique Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
description	SUMMARY: As a result of their intense physical activity, racehorses suffer high tendon stress which may result in various pathologies. One of these is tendonitis in the tendon of the superficial digital flexor muscle (TSDFM). Conventional treatment with rest, has not shown to be very effective, and regenerative medicine through the application mesenchymal stem cells appears to be a promising therapy. The objective of this work was to assess the effect of the application of autologous MSC on reduction of the scar length in recurrent TSDFM tendinitis in Holsteiner horses, using image analysis. This study included two groups of five animals each: A control group that received conventional treatment (CG) and an experimental group which was also treated with intralesional injections of MSC (EG). Scar evolution was assessed by echographic analysis, with measurements taken of the scar length over a four month period; the length at month zero, was taken as the initial value of 100 %. During the first month, the mean scar length diminished to 81.14 % (EG) and 95.85 % (CG); after the second month, lengths were 64.4 % (EG) and 92.3 % (CG); following the third month lengths were 51.92 % (EG) and 87.42 % (CG); finally at the end of the fourth month the lengths recorded were 26.7 % (EG) and 83.92 % (CG). These results show that treatment with autologous MSC helps TSDFM scar length was significantly reduced, as compared to conventional treatment.
author	Rivera,Christopher Tuemmers,Christian Bañados,Rodrigo Vidal-Seguel,Nicolás Montiel-Eulefi,Enrique
author_facet	Rivera,Christopher Tuemmers,Christian Bañados,Rodrigo Vidal-Seguel,Nicolás Montiel-Eulefi,Enrique
author_sort	Rivera,Christopher
title	Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
title_short	Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
title_full	Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
title_fullStr	Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
title_full_unstemmed	Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)
title_sort	reduction of recurrent tendinitis scar using autologous mesenchymal stem cells derived from adipose tissue from the base of the tail in holsteiner horses (equus ferus caballus)
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100186
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Reduction of Recurrent Tendinitis Scar Using Autologous Mesenchymal Stem Cells Derived from Adipose Tissue from the Base of the Tail in Holsteiner Horses (Equus ferus caballus)

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