Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats

SUMMARY: The potential inhibitory effect of the insulin mimicking agent, vanadium on type 2 diabetes mellitus (T2DM)induced alterations to the aorta ultrastructure associated with the suppression of dyslipedima and biomarkers of inflammation has not been investigated before. Therefore, we tested whe...

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Autores principales:	Bin-Jaliah,Ismaeel, Morsy,M. D, Al-Ani,Bahjat, Eid,Refaat A, Haidara,Mohamed A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Diabetes Aortic injury Inflammation Vanadium Rat model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100215
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spelling	oai:scielo:S0717-950220200001002152019-11-22Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in RatsBin-Jaliah,IsmaeelMorsy,M. DAl-Ani,BahjatEid,Refaat AHaidara,Mohamed A Diabetes Aortic injury Inflammation Vanadium Rat model SUMMARY: The potential inhibitory effect of the insulin mimicking agent, vanadium on type 2 diabetes mellitus (T2DM)induced alterations to the aorta ultrastructure associated with the suppression of dyslipedima and biomarkers of inflammation has not been investigated before. Therefore, we tested whether vanadium can protect against aortic injury induced secondary to T2DM possibly via the inhibition of blood lipid and inflammatory biomarkers. T2DM was induced in rats by a high-fat diet and streptozotocin (50 mg/ kg), and the treatment group started vanadium treatment five days post diabetic induction and continued until being sacrificed at week 10. Using light and electron microscopy examinations, we observed in the model group substantial damage to the aorta tissue such as damaged endothelium, degenerative cellular changes with vacuolated cytoplasm and thickened internal elastic lamina that were substantially ameliorated by vanadium. Administration of vanadium to diabetic rats also significantly (p<0.05) reduced blood levels of glucose, hyperlipidemia and biomarkers of inflammation (TNF-a, IL-6). We conclude that vanadium protects against T2DM-induced aortic ultrastructural damage in rats, which is associated with the inhibition of blood sugar and lipid and inflammatory biomarkers.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100215en10.4067/S0717-95022020000100215
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes Aortic injury Inflammation Vanadium Rat model
spellingShingle	Diabetes Aortic injury Inflammation Vanadium Rat model Bin-Jaliah,Ismaeel Morsy,M. D Al-Ani,Bahjat Eid,Refaat A Haidara,Mohamed A Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
description	SUMMARY: The potential inhibitory effect of the insulin mimicking agent, vanadium on type 2 diabetes mellitus (T2DM)induced alterations to the aorta ultrastructure associated with the suppression of dyslipedima and biomarkers of inflammation has not been investigated before. Therefore, we tested whether vanadium can protect against aortic injury induced secondary to T2DM possibly via the inhibition of blood lipid and inflammatory biomarkers. T2DM was induced in rats by a high-fat diet and streptozotocin (50 mg/ kg), and the treatment group started vanadium treatment five days post diabetic induction and continued until being sacrificed at week 10. Using light and electron microscopy examinations, we observed in the model group substantial damage to the aorta tissue such as damaged endothelium, degenerative cellular changes with vacuolated cytoplasm and thickened internal elastic lamina that were substantially ameliorated by vanadium. Administration of vanadium to diabetic rats also significantly (p<0.05) reduced blood levels of glucose, hyperlipidemia and biomarkers of inflammation (TNF-a, IL-6). We conclude that vanadium protects against T2DM-induced aortic ultrastructural damage in rats, which is associated with the inhibition of blood sugar and lipid and inflammatory biomarkers.
author	Bin-Jaliah,Ismaeel Morsy,M. D Al-Ani,Bahjat Eid,Refaat A Haidara,Mohamed A
author_facet	Bin-Jaliah,Ismaeel Morsy,M. D Al-Ani,Bahjat Eid,Refaat A Haidara,Mohamed A
author_sort	Bin-Jaliah,Ismaeel
title	Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
title_short	Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
title_full	Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
title_fullStr	Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
title_full_unstemmed	Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats
title_sort	vanadium inhibits type 2 diabetes mellitus-induced aortic ultrastructural alterations associated with the inhibition of dyslipidemia and biomarkers of inflammation in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000100215
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Vanadium Inhibits Type 2 Diabetes Mellitus-Induced Aortic Ultrastructural Alterations Associated with the Inhibition of Dyslipidemia and Biomarkers of Inflammation in Rats

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