Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma
SUMMARY: Nine tumor and various potential biomarkers were measured and combined the information to diagnose disease, all patients accepted fiber bronchoscopy brush liquid based cytologyand histopathology examination in order to reliably detect lung cancer. The samples from 314 Chinese lung cancer pa...
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Sociedad Chilena de Anatomía
2020
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oai:scielo:S0717-950220200002002472020-02-03Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung CarcinomaWang,Jing-yuanWang,Xue-minXu,Xiao-yanLi,Shi-rongLiu,Xiu-lan Lung cancer Histopathology Diagnostic value Biomarkers SUMMARY: Nine tumor and various potential biomarkers were measured and combined the information to diagnose disease, all patients accepted fiber bronchoscopy brush liquid based cytologyand histopathology examination in order to reliably detect lung cancer. The samples from 314 Chinese lung cancer patients were obtained and CK5/6, P63, P40, CK7, TTF-1, NapsinA CD56, Syn and CgA were measured with the immunohistochemical SP method and analyzed correlation of the expression of these markers with pathological and clinical features of squamous cell carcinoma, adenocarcinoma, and small cell lung carcinoma. Squamous cell carcinoma, adenocarcinoma and small cell carcinoma were 61 cases, 114 cases and 139 cases,CK5/6 and P63 expression were more frequent in squamous cell carcinoma, with sensitivity and specificity of 77.05 % and 96.44 %, 83.61 % and 88.93 %,and compared with adenocarcinoma and small cell carcinoma difference was statistically significant (P<0.05), The incidences of a positive P40 expression were 100 % in squamous cell carcinoma, with specificity of 98.81 %.CK7, TTF-1 and NapsinA expression were more frequent in adenocarcinoma, with sensitivity and specificity of 85.09 % and 78.69 %, 79.82 % and 93.44 %, 56.14 % and 95.08 %, and compared with squamous cell carcinoma and small cell carcinoma difference was statistically significant (P<0.05). TTF-1, Syn, CgA and CD56 expression were more frequent in adenocarcinoma, with sensitivity and specificity of 86.33 % and 93.44 %, 89.21 % and 98.36 %, 74.10 % and 100 %, 96.40 % and 96.72 %. The combined detection of CK5/6, P63 and P40 were more useful and specific in differentiating squamous cell carcinoma. CK7, TTF-1 and NapsinA were more useful and specific in differentiating lung adenocarcinoma. The impaired CD56, TTF-1, Syn and CgA reflects the progression of small cell lung cancer.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.2 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200247en10.4067/S0717-95022020000200247 |
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Scielo Chile |
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Scielo Chile |
| language |
English |
| topic |
Lung cancer Histopathology Diagnostic value Biomarkers |
| spellingShingle |
Lung cancer Histopathology Diagnostic value Biomarkers Wang,Jing-yuan Wang,Xue-min Xu,Xiao-yan Li,Shi-rong Liu,Xiu-lan Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| description |
SUMMARY: Nine tumor and various potential biomarkers were measured and combined the information to diagnose disease, all patients accepted fiber bronchoscopy brush liquid based cytologyand histopathology examination in order to reliably detect lung cancer. The samples from 314 Chinese lung cancer patients were obtained and CK5/6, P63, P40, CK7, TTF-1, NapsinA CD56, Syn and CgA were measured with the immunohistochemical SP method and analyzed correlation of the expression of these markers with pathological and clinical features of squamous cell carcinoma, adenocarcinoma, and small cell lung carcinoma. Squamous cell carcinoma, adenocarcinoma and small cell carcinoma were 61 cases, 114 cases and 139 cases,CK5/6 and P63 expression were more frequent in squamous cell carcinoma, with sensitivity and specificity of 77.05 % and 96.44 %, 83.61 % and 88.93 %,and compared with adenocarcinoma and small cell carcinoma difference was statistically significant (P<0.05), The incidences of a positive P40 expression were 100 % in squamous cell carcinoma, with specificity of 98.81 %.CK7, TTF-1 and NapsinA expression were more frequent in adenocarcinoma, with sensitivity and specificity of 85.09 % and 78.69 %, 79.82 % and 93.44 %, 56.14 % and 95.08 %, and compared with squamous cell carcinoma and small cell carcinoma difference was statistically significant (P<0.05). TTF-1, Syn, CgA and CD56 expression were more frequent in adenocarcinoma, with sensitivity and specificity of 86.33 % and 93.44 %, 89.21 % and 98.36 %, 74.10 % and 100 %, 96.40 % and 96.72 %. The combined detection of CK5/6, P63 and P40 were more useful and specific in differentiating squamous cell carcinoma. CK7, TTF-1 and NapsinA were more useful and specific in differentiating lung adenocarcinoma. The impaired CD56, TTF-1, Syn and CgA reflects the progression of small cell lung cancer. |
| author |
Wang,Jing-yuan Wang,Xue-min Xu,Xiao-yan Li,Shi-rong Liu,Xiu-lan |
| author_facet |
Wang,Jing-yuan Wang,Xue-min Xu,Xiao-yan Li,Shi-rong Liu,Xiu-lan |
| author_sort |
Wang,Jing-yuan |
| title |
Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| title_short |
Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| title_full |
Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| title_fullStr |
Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| title_full_unstemmed |
Expression and Significance of CK5/6, P63, P40, CK7, TTF-1, NapsinA, CD56, Syn and CgA in Biopsy Specimen of Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Lung Carcinoma |
| title_sort |
expression and significance of ck5/6, p63, p40, ck7, ttf-1, napsina, cd56, syn and cga in biopsy specimen of squamous cell carcinoma, adenocarcinoma and small cell lung carcinoma |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200247 |
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