Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos

SUMMARY: The family of paired box (Pax) genes encodes the transcription factors that have been emphasized for the particular importance to embryonic development of the CNS, with the evidence obtained from various animal models. Human embryos have rarely been available for the detection of the expres...

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Autores principales:	Namm,Aimar, Arend,Andres, Suutre,Siim, Aunapuu,Marina
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Human embryos Pax6 and Pax7 Developing spinal cord and brain
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200259
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spelling	oai:scielo:S0717-950220200002002592020-02-03Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human EmbryosNamm,AimarArend,AndresSuutre,SiimAunapuu,Marina Human embryos Pax6 and Pax7 Developing spinal cord and brain SUMMARY: The family of paired box (Pax) genes encodes the transcription factors that have been emphasized for the particular importance to embryonic development of the CNS, with the evidence obtained from various animal models. Human embryos have rarely been available for the detection of the expression of Pax family members. In this study 32 human embryos of Carnegie (CS) stages 10-20 were investigated to find the differences in the expression of Pax6 and Pax7 proteins in different regions of the neural tube and the caudal spinal cord. The expression of Pax6 and Pax7, as determined by immunohistochemistry, showed a tendency to increase in the later stages of the development both in the spinal cord and the brain. Significantly weaker expression of Pax6 and Pax7 was observed at CS 10 as compared to the later stages. At CS 10-12 weak expression of Pax6 was noticed in both dorsal and ventral parts of the developing spinal cord, while the expression of Pax7 was restricted to the cells in the roof plate and the dorsal part of the spinal cord. At CS 14-20 in the developing spinal cord Pax6 and Pax7 were detected mostly in the neuroepithelial cells of the ventricular layer, while only weak expression characterized the mantle and the marginal layers. At the same stages in the developing brain Pax6 and Pax7 were expressed in the different regions of the forebrain, the midbrain and the hindbrain suggesting for their involvement in the differentiation of neurons in specific parts of the developing brain.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.2 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200259en10.4067/S0717-95022020000200259
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Human embryos Pax6 and Pax7 Developing spinal cord and brain
spellingShingle	Human embryos Pax6 and Pax7 Developing spinal cord and brain Namm,Aimar Arend,Andres Suutre,Siim Aunapuu,Marina Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
description	SUMMARY: The family of paired box (Pax) genes encodes the transcription factors that have been emphasized for the particular importance to embryonic development of the CNS, with the evidence obtained from various animal models. Human embryos have rarely been available for the detection of the expression of Pax family members. In this study 32 human embryos of Carnegie (CS) stages 10-20 were investigated to find the differences in the expression of Pax6 and Pax7 proteins in different regions of the neural tube and the caudal spinal cord. The expression of Pax6 and Pax7, as determined by immunohistochemistry, showed a tendency to increase in the later stages of the development both in the spinal cord and the brain. Significantly weaker expression of Pax6 and Pax7 was observed at CS 10 as compared to the later stages. At CS 10-12 weak expression of Pax6 was noticed in both dorsal and ventral parts of the developing spinal cord, while the expression of Pax7 was restricted to the cells in the roof plate and the dorsal part of the spinal cord. At CS 14-20 in the developing spinal cord Pax6 and Pax7 were detected mostly in the neuroepithelial cells of the ventricular layer, while only weak expression characterized the mantle and the marginal layers. At the same stages in the developing brain Pax6 and Pax7 were expressed in the different regions of the forebrain, the midbrain and the hindbrain suggesting for their involvement in the differentiation of neurons in specific parts of the developing brain.
author	Namm,Aimar Arend,Andres Suutre,Siim Aunapuu,Marina
author_facet	Namm,Aimar Arend,Andres Suutre,Siim Aunapuu,Marina
author_sort	Namm,Aimar
title	Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
title_short	Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
title_full	Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
title_fullStr	Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
title_full_unstemmed	Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos
title_sort	expression of pax6 and pax7 proteins during the central nervous system development in human embryos
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200259
work_keys_str_mv	AT nammaimar expressionofpax6andpax7proteinsduringthecentralnervoussystemdevelopmentinhumanembryos AT arendandres expressionofpax6andpax7proteinsduringthecentralnervoussystemdevelopmentinhumanembryos AT suutresiim expressionofpax6andpax7proteinsduringthecentralnervoussystemdevelopmentinhumanembryos AT aunapuumarina expressionofpax6andpax7proteinsduringthecentralnervoussystemdevelopmentinhumanembryos
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Expression of Pax6 and Pax7 Proteins During the Central Nervous System Development in Human Embryos

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