Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats

SUMMARY: Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type...

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Autores principales:	Al-Doaiss,Amin Abdullah, Al-Shehri,Mohammed Ali
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Diabetes mellitus Testes Gum Arabic Histology Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200340
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spelling	oai:scielo:S0717-950220200002003402020-02-03Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic RatsAl-Doaiss,Amin AbdullahAl-Shehri,Mohammed Ali Diabetes mellitus Testes Gum Arabic Histology Rat SUMMARY: Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic rats have not been enough investigated. This study was designed to investigate histological changes in testes of male Wistar rats and investigate the protective potential of GA against diabetes- induced testicular toxicity in rats. Fifty adult male Wistar rats were assigned into five groups (n = 10 of each): Group 1 (non-diabetic rats) served as control, Group 2 served as diabetic group injected with Alloxan, Group 3 diabetic group plus insulin, Group 4 diabetic group given 15 % GA in drinking water and Group 5 diabetic group plus insulin and GA for 4 weeks. Compared to control group, histopathological examinations of testicular tissue from the diabetic rats group, showed degeneration, necrosis and atrophy of seminiferous with presence of giant cells. Necrosis and hemorrhage in the renal tissue. On the other hand, treatment with GA ameliorated all the previous histological changes. Overall, oral administration of GA alone or with insulin daily for 4 weeks successfully ameliorated the testicular histological changes. These data demonstrated that GA significantly improved diabetes complication in rat testis. This study suggested that GA might have a protective effect against oxidative stress-induced impaired testicular functions in diabetic rats. The possible mechanisms of this action might be ascribed to their antioxidant and anti-inflammatory properties.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.2 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200340en10.4067/S0717-95022020000200340
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes mellitus Testes Gum Arabic Histology Rat
spellingShingle	Diabetes mellitus Testes Gum Arabic Histology Rat Al-Doaiss,Amin Abdullah Al-Shehri,Mohammed Ali Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
description	SUMMARY: Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic rats have not been enough investigated. This study was designed to investigate histological changes in testes of male Wistar rats and investigate the protective potential of GA against diabetes- induced testicular toxicity in rats. Fifty adult male Wistar rats were assigned into five groups (n = 10 of each): Group 1 (non-diabetic rats) served as control, Group 2 served as diabetic group injected with Alloxan, Group 3 diabetic group plus insulin, Group 4 diabetic group given 15 % GA in drinking water and Group 5 diabetic group plus insulin and GA for 4 weeks. Compared to control group, histopathological examinations of testicular tissue from the diabetic rats group, showed degeneration, necrosis and atrophy of seminiferous with presence of giant cells. Necrosis and hemorrhage in the renal tissue. On the other hand, treatment with GA ameliorated all the previous histological changes. Overall, oral administration of GA alone or with insulin daily for 4 weeks successfully ameliorated the testicular histological changes. These data demonstrated that GA significantly improved diabetes complication in rat testis. This study suggested that GA might have a protective effect against oxidative stress-induced impaired testicular functions in diabetic rats. The possible mechanisms of this action might be ascribed to their antioxidant and anti-inflammatory properties.
author	Al-Doaiss,Amin Abdullah Al-Shehri,Mohammed Ali
author_facet	Al-Doaiss,Amin Abdullah Al-Shehri,Mohammed Ali
author_sort	Al-Doaiss,Amin Abdullah
title	Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
title_short	Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
title_full	Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
title_fullStr	Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
title_full_unstemmed	Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats
title_sort	protective effect of gum arabic/insulin against histological changes in testes of diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200340
work_keys_str_mv	AT aldoaissaminabdullah protectiveeffectofgumarabicinsulinagainsthistologicalchangesintestesofdiabeticrats AT alshehrimohammedali protectiveeffectofgumarabicinsulinagainsthistologicalchangesintestesofdiabeticrats
_version_	1718445137869144064

Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats

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