Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring

SUMMARY: Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. Glucocorticoid receptor (GR) is an important target of glucocorticoid. Therefore the aim of the present study was to investigate the expres...

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Autores principales:	Liao,Libin, Yao,Xueping, Huang,Jufang, Bai,Shengbin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Prenatal stress Cognitive impairment Glucocorticoid receptor Hippocampus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200400
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spelling	oai:scielo:S0717-950220200002004002020-02-03Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat OffspringLiao,LibinYao,XuepingHuang,JufangBai,Shengbin Prenatal stress Cognitive impairment Glucocorticoid receptor Hippocampus SUMMARY: Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. Glucocorticoid receptor (GR) is an important target of glucocorticoid. Therefore the aim of the present study was to investigate the expression of GR in prenatally stressed adult offspring and the relationship between GR expression and behavior in offspring. Pregnant rats received restraint stress during the last week of pregnancy. Hippocampal glucocorticoid receptor expression levels in the offspring were detected on postnatal 60 (P60).Cognition function was also detected. It shows significantly lower hippocampal GR expression was observed in female prenatally stressed offspring compared with their controls at P60. Corresponding to the expression of GR, female prenatally stressed offspring exhibited poorer spatial learning and memory abilities in the Barnes maze than control, This suggests that cognitive impairment in prenatally stressed rat offspring attribute lower hippocampal GR expression.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.2 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200400en10.4067/S0717-95022020000200400
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Prenatal stress Cognitive impairment Glucocorticoid receptor Hippocampus
spellingShingle	Prenatal stress Cognitive impairment Glucocorticoid receptor Hippocampus Liao,Libin Yao,Xueping Huang,Jufang Bai,Shengbin Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
description	SUMMARY: Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. Glucocorticoid receptor (GR) is an important target of glucocorticoid. Therefore the aim of the present study was to investigate the expression of GR in prenatally stressed adult offspring and the relationship between GR expression and behavior in offspring. Pregnant rats received restraint stress during the last week of pregnancy. Hippocampal glucocorticoid receptor expression levels in the offspring were detected on postnatal 60 (P60).Cognition function was also detected. It shows significantly lower hippocampal GR expression was observed in female prenatally stressed offspring compared with their controls at P60. Corresponding to the expression of GR, female prenatally stressed offspring exhibited poorer spatial learning and memory abilities in the Barnes maze than control, This suggests that cognitive impairment in prenatally stressed rat offspring attribute lower hippocampal GR expression.
author	Liao,Libin Yao,Xueping Huang,Jufang Bai,Shengbin
author_facet	Liao,Libin Yao,Xueping Huang,Jufang Bai,Shengbin
author_sort	Liao,Libin
title	Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
title_short	Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
title_full	Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
title_fullStr	Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
title_full_unstemmed	Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring
title_sort	prenatal stress up-regulated hippocampal glucocorticoid receptor expression in female adult rat offspring
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200400
work_keys_str_mv	AT liaolibin prenatalstressupregulatedhippocampalglucocorticoidreceptorexpressioninfemaleadultratoffspring AT yaoxueping prenatalstressupregulatedhippocampalglucocorticoidreceptorexpressioninfemaleadultratoffspring AT huangjufang prenatalstressupregulatedhippocampalglucocorticoidreceptorexpressioninfemaleadultratoffspring AT baishengbin prenatalstressupregulatedhippocampalglucocorticoidreceptorexpressioninfemaleadultratoffspring
_version_	1718445139637043200

Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring

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