Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum

SUMMARY: Sexual dimorphism exists at all levels of the nervous system. These sex differences could underlie genderrelated differences in behavior and neuropsychological function, as well as the gender differences in the prevalence of various mental disorders such as autism, attention deficit disorde...

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Autores principales:	Shatarat,Amjad, Alzghoul,Loai, Al-Qattan,Duaa, ELBeltagy,Maha
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Dimorphism Corpus callosum (CC) Electron microscope Myelinated axons Diameter and myelin sheath thickness
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200505
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spelling	oai:scielo:S0717-950220200002005052020-02-03Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus CallosumShatarat,AmjadAlzghoul,LoaiAl-Qattan,DuaaELBeltagy,Maha Dimorphism Corpus callosum (CC) Electron microscope Myelinated axons Diameter and myelin sheath thickness SUMMARY: Sexual dimorphism exists at all levels of the nervous system. These sex differences could underlie genderrelated differences in behavior and neuropsychological function, as well as the gender differences in the prevalence of various mental disorders such as autism, attention deficit disorders, and schizophrenia. Myelination, on the other hand, is a unique cellular process that can have a dramatic impact on the structure and physiology of an axon and its surrounding tissue. The corpus callosum (CC) is the largest of the brain commissures, which connects the cerebral cortices of the two hemispheres, and provides interhemispheric connectivity for information transfer and processing between cortical regions. Variation in the axonal properties of CC will alter the interhemispheric connectivity. The CC consists of myelinated and unmyelinated axons, glial cells and blood vessels. Several functional studies have reported that the function of CC is associated with its axons density and myelination properties. The sexual dimorphism in the axonal content of the CC has always been controversial; hence, the aim of this study was to analyze the differences in axons’ diameter and myelin sheath thickness of the CC between male and female rats. For this purpose, five pairs of adult male and female rats were perfused and the CC were removed and sectioned. Four sections from different subregions of the corpus callosum that represent the genu, anterior body, posterior body, and splenium of the CC were stained and electron microscopic images were captured using stereological guidelines. Later, the axons diameter and myelin sheath thickness for each subregion were calculated and compared between males and females. Our preliminary findings of the present study indicated region specific differences in the myelinated axon thickness and diameter in the CC between male and female rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.2 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200505en10.4067/S0717-95022020000200505
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Dimorphism Corpus callosum (CC) Electron microscope Myelinated axons Diameter and myelin sheath thickness
spellingShingle	Dimorphism Corpus callosum (CC) Electron microscope Myelinated axons Diameter and myelin sheath thickness Shatarat,Amjad Alzghoul,Loai Al-Qattan,Duaa ELBeltagy,Maha Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
description	SUMMARY: Sexual dimorphism exists at all levels of the nervous system. These sex differences could underlie genderrelated differences in behavior and neuropsychological function, as well as the gender differences in the prevalence of various mental disorders such as autism, attention deficit disorders, and schizophrenia. Myelination, on the other hand, is a unique cellular process that can have a dramatic impact on the structure and physiology of an axon and its surrounding tissue. The corpus callosum (CC) is the largest of the brain commissures, which connects the cerebral cortices of the two hemispheres, and provides interhemispheric connectivity for information transfer and processing between cortical regions. Variation in the axonal properties of CC will alter the interhemispheric connectivity. The CC consists of myelinated and unmyelinated axons, glial cells and blood vessels. Several functional studies have reported that the function of CC is associated with its axons density and myelination properties. The sexual dimorphism in the axonal content of the CC has always been controversial; hence, the aim of this study was to analyze the differences in axons’ diameter and myelin sheath thickness of the CC between male and female rats. For this purpose, five pairs of adult male and female rats were perfused and the CC were removed and sectioned. Four sections from different subregions of the corpus callosum that represent the genu, anterior body, posterior body, and splenium of the CC were stained and electron microscopic images were captured using stereological guidelines. Later, the axons diameter and myelin sheath thickness for each subregion were calculated and compared between males and females. Our preliminary findings of the present study indicated region specific differences in the myelinated axon thickness and diameter in the CC between male and female rats.
author	Shatarat,Amjad Alzghoul,Loai Al-Qattan,Duaa ELBeltagy,Maha
author_facet	Shatarat,Amjad Alzghoul,Loai Al-Qattan,Duaa ELBeltagy,Maha
author_sort	Shatarat,Amjad
title	Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
title_short	Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
title_full	Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
title_fullStr	Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
title_full_unstemmed	Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum
title_sort	anatomical and ultrastructural sex differences in mean diameter and thickness of myelinated axons in adult rat corpus callosum
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000200505
work_keys_str_mv	AT shataratamjad anatomicalandultrastructuralsexdifferencesinmeandiameterandthicknessofmyelinatedaxonsinadultratcorpuscallosum AT alzghoulloai anatomicalandultrastructuralsexdifferencesinmeandiameterandthicknessofmyelinatedaxonsinadultratcorpuscallosum AT alqattanduaa anatomicalandultrastructuralsexdifferencesinmeandiameterandthicknessofmyelinatedaxonsinadultratcorpuscallosum AT elbeltagymaha anatomicalandultrastructuralsexdifferencesinmeandiameterandthicknessofmyelinatedaxonsinadultratcorpuscallosum
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Anatomical and Ultrastructural Sex Differences in Mean Diameter and Thickness of Myelinated Axons in Adult Rat Corpus Callosum

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