AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model

AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model

SUMMARY: The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 protein...

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Autores principales: Abrahão,Dayana Pousa Siqueira, Lizarte Neto,Fermino Sanches, Rodrigues,Andressa Romualdo, Cirino,Múcio Luiz de Assis, Silva,Jairo Pinheiro da, Sarraipo,Vagner Schiavoni, Carvalho,Camila Albuquerque Melo de, Tazima,Maria de Fátima Galli Sorita, Carlotti-Jr.,Carlos Gilberto, Colli,Benedicto Oscar, Tirapelli,Luís Fernando, Tirapelli,Daniela Pretti da Cunha
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2020
Materias:
PARP-1
AIF
miRNA-9
Cerebral ischemia
Alcoholism
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300616
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spelling oai:scielo:S0717-950220200003006162020-04-07AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental ModelAbrahão,Dayana Pousa SiqueiraLizarte Neto,Fermino SanchesRodrigues,Andressa RomualdoCirino,Múcio Luiz de AssisSilva,Jairo Pinheiro daSarraipo,Vagner SchiavoniCarvalho,Camila Albuquerque Melo deTazima,Maria de Fátima Galli SoritaCarlotti-Jr.,Carlos GilbertoColli,Benedicto OscarTirapelli,Luís FernandoTirapelli,Daniela Pretti da Cunha PARP-1 AIF miRNA-9 Cerebral ischemia Alcoholism SUMMARY: The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 proteins in rats submitted to focal cerebral ischemia, associated or not with chronic alcoholism model. Methods: Twenty adult Wistar rats, subdivided into: control; ischemic; alcoholic and ischemic / alcoholized for immunohistochemical analysis and miRNA-9 gene expression. Results: There was a reduction in the protein expression of PARP-1 and a positive marking for AIF in the ischemic / alcoholized group. The miRNA-9 did not obtain significant expression. The association of ischemia with chronic alcohol use promoted a tendency to low expression of miRNA-9, low expression of PARP-1 and high expression of AIF, indicating an interference in the protective effect of miRNA-9 be observed in the other groups.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.3 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300616en10.4067/S0717-95022020000300616
institution Scielo Chile
collection Scielo Chile
language English
topic PARP-1
AIF
miRNA-9
Cerebral ischemia
Alcoholism
spellingShingle PARP-1
AIF
miRNA-9
Cerebral ischemia
Alcoholism
Abrahão,Dayana Pousa Siqueira
Lizarte Neto,Fermino Sanches
Rodrigues,Andressa Romualdo
Cirino,Múcio Luiz de Assis
Silva,Jairo Pinheiro da
Sarraipo,Vagner Schiavoni
Carvalho,Camila Albuquerque Melo de
Tazima,Maria de Fátima Galli Sorita
Carlotti-Jr.,Carlos Gilberto
Colli,Benedicto Oscar
Tirapelli,Luís Fernando
Tirapelli,Daniela Pretti da Cunha
AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
description SUMMARY: The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 proteins in rats submitted to focal cerebral ischemia, associated or not with chronic alcoholism model. Methods: Twenty adult Wistar rats, subdivided into: control; ischemic; alcoholic and ischemic / alcoholized for immunohistochemical analysis and miRNA-9 gene expression. Results: There was a reduction in the protein expression of PARP-1 and a positive marking for AIF in the ischemic / alcoholized group. The miRNA-9 did not obtain significant expression. The association of ischemia with chronic alcohol use promoted a tendency to low expression of miRNA-9, low expression of PARP-1 and high expression of AIF, indicating an interference in the protective effect of miRNA-9 be observed in the other groups.
author Abrahão,Dayana Pousa Siqueira
Lizarte Neto,Fermino Sanches
Rodrigues,Andressa Romualdo
Cirino,Múcio Luiz de Assis
Silva,Jairo Pinheiro da
Sarraipo,Vagner Schiavoni
Carvalho,Camila Albuquerque Melo de
Tazima,Maria de Fátima Galli Sorita
Carlotti-Jr.,Carlos Gilberto
Colli,Benedicto Oscar
Tirapelli,Luís Fernando
Tirapelli,Daniela Pretti da Cunha
author_facet Abrahão,Dayana Pousa Siqueira
Lizarte Neto,Fermino Sanches
Rodrigues,Andressa Romualdo
Cirino,Múcio Luiz de Assis
Silva,Jairo Pinheiro da
Sarraipo,Vagner Schiavoni
Carvalho,Camila Albuquerque Melo de
Tazima,Maria de Fátima Galli Sorita
Carlotti-Jr.,Carlos Gilberto
Colli,Benedicto Oscar
Tirapelli,Luís Fernando
Tirapelli,Daniela Pretti da Cunha
author_sort Abrahão,Dayana Pousa Siqueira
title AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
title_short AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
title_full AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
title_fullStr AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
title_full_unstemmed AIF, PARP-1 and MicroRNA-9 Expression in Cerebral Ischemia Associated to Alcoholism Experimental Model
title_sort aif, parp-1 and microrna-9 expression in cerebral ischemia associated to alcoholism experimental model
publisher Sociedad Chilena de Anatomía
publishDate 2020
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300616
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