Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats
SUMMARY: Diabetes Mellitus (DM) is a condition marked by hyperglycaemia that causes systemic complications, including urinary vesicle dysfunction due to oxidative stress. Further, antioxidants, as well as alpha lipoic acid (ALA), may be a response to this pathological condition. The present study ve...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Anatomía
2020
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300627 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0717-95022020000300627 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0717-950220200003006272020-04-07Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic RatsCorrêa,Lanna Beatriz Neves SilvaRamos,Cristiane Simões Coelho BrittoAbboud,Renato de SouzaRibeiro,Ilma Cely de AmorimRopke-Junior,ReinaldoBoaventura,Gilson TelesChagas,Mauricio Alves Antioxidants Thioctic acid Urinary Hyperglycemia Histological SUMMARY: Diabetes Mellitus (DM) is a condition marked by hyperglycaemia that causes systemic complications, including urinary vesicle dysfunction due to oxidative stress. Further, antioxidants, as well as alpha lipoic acid (ALA), may be a response to this pathological condition. The present study verified the action of ALA as a supplement in ration on glycemia and urinary vesicle structures of rats induced by streptozotocin. The rats were divided into 4 groups: Control (CG), Alpha Lipoic (ALAG), Diabetic control (DCG), and the Diabetic alpha lipoic (DALAG) group. For induction, the diabetic groups were initially induced with streptozotocin (dose 60 mg/kg). Subsequently, group glycemia was evaluated weekly. After 8 weeks, the rats were euthanized and the bladder was collected. The bladders were histologically processed and the slides were stained with Masson’s Trichrome for the histomorphometry of epithelial height, connective and muscular tissue and coloration of PicroSirius Red for further analysis of collagen fibers of the bladder. The data of the glycemia demonstrated an inferior median in DALAG compared to DGC (p<0.01). The epithelial height and percentage of the muscle tissue were greater in DALAG compared to the DGC, but not significant. However, GDAL showed improvement in the organization of collagen fibers. In conclusion, bladder the morphology alterations caused by DM were not alleviated by the administration of ALA in 8 weeks of the experiments.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.3 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300627en10.4067/S0717-95022020000300627 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Antioxidants Thioctic acid Urinary Hyperglycemia Histological |
| spellingShingle |
Antioxidants Thioctic acid Urinary Hyperglycemia Histological Corrêa,Lanna Beatriz Neves Silva Ramos,Cristiane Simões Coelho Britto Abboud,Renato de Souza Ribeiro,Ilma Cely de Amorim Ropke-Junior,Reinaldo Boaventura,Gilson Teles Chagas,Mauricio Alves Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| description |
SUMMARY: Diabetes Mellitus (DM) is a condition marked by hyperglycaemia that causes systemic complications, including urinary vesicle dysfunction due to oxidative stress. Further, antioxidants, as well as alpha lipoic acid (ALA), may be a response to this pathological condition. The present study verified the action of ALA as a supplement in ration on glycemia and urinary vesicle structures of rats induced by streptozotocin. The rats were divided into 4 groups: Control (CG), Alpha Lipoic (ALAG), Diabetic control (DCG), and the Diabetic alpha lipoic (DALAG) group. For induction, the diabetic groups were initially induced with streptozotocin (dose 60 mg/kg). Subsequently, group glycemia was evaluated weekly. After 8 weeks, the rats were euthanized and the bladder was collected. The bladders were histologically processed and the slides were stained with Masson’s Trichrome for the histomorphometry of epithelial height, connective and muscular tissue and coloration of PicroSirius Red for further analysis of collagen fibers of the bladder. The data of the glycemia demonstrated an inferior median in DALAG compared to DGC (p<0.01). The epithelial height and percentage of the muscle tissue were greater in DALAG compared to the DGC, but not significant. However, GDAL showed improvement in the organization of collagen fibers. In conclusion, bladder the morphology alterations caused by DM were not alleviated by the administration of ALA in 8 weeks of the experiments. |
| author |
Corrêa,Lanna Beatriz Neves Silva Ramos,Cristiane Simões Coelho Britto Abboud,Renato de Souza Ribeiro,Ilma Cely de Amorim Ropke-Junior,Reinaldo Boaventura,Gilson Teles Chagas,Mauricio Alves |
| author_facet |
Corrêa,Lanna Beatriz Neves Silva Ramos,Cristiane Simões Coelho Britto Abboud,Renato de Souza Ribeiro,Ilma Cely de Amorim Ropke-Junior,Reinaldo Boaventura,Gilson Teles Chagas,Mauricio Alves |
| author_sort |
Corrêa,Lanna Beatriz Neves Silva |
| title |
Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| title_short |
Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| title_full |
Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| title_fullStr |
Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| title_full_unstemmed |
Influence of Alpha Lipoic Acid Supplementation on Urinary Bladder Morphology of Diabetic Rats |
| title_sort |
influence of alpha lipoic acid supplementation on urinary bladder morphology of diabetic rats |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300627 |
| work_keys_str_mv |
AT correalannabeatriznevessilva influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT ramoscristianesimoescoelhobritto influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT abboudrenatodesouza influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT ribeiroilmacelydeamorim influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT ropkejuniorreinaldo influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT boaventuragilsonteles influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats AT chagasmauricioalves influenceofalphalipoicacidsupplementationonurinarybladdermorphologyofdiabeticrats |
| _version_ |
1718445145679986688 |