Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats

SUMMARY: The aim was to evaluate bone repair and gingival tissue repair in osteopenic rats. Fifteen female wistar rats were included; in all of them ovariectomy was realized to induce osteopenia; after 45 days, the animals were submitted to 2 surgical techinques 1) dental extraction of the upper cen...

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Autores principales:	Quinto,José Henrique Santana, Sigua-Rodriguez,Eder Alberto, Natali,Maria Raquel Marçal, Olate,Sergio, Cuman,Roberto Kenji Nakamura, Farah,Gustavo Jacobucci
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Biphosphonate Osteonecrosis Osteoporosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300683
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spelling	oai:scielo:S0717-950220200003006832020-04-07Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic RatsQuinto,José Henrique SantanaSigua-Rodriguez,Eder AlbertoNatali,Maria Raquel MarçalOlate,SergioCuman,Roberto Kenji NakamuraFarah,Gustavo Jacobucci Biphosphonate Osteonecrosis Osteoporosis SUMMARY: The aim was to evaluate bone repair and gingival tissue repair in osteopenic rats. Fifteen female wistar rats were included; in all of them ovariectomy was realized to induce osteopenia; after 45 days, the animals were submitted to 2 surgical techinques 1) dental extraction of the upper central incisor with no socket preservation and 2) 5 mm cranial defect in the calvarium; 5 rats were included in the control group (G1) withput alendronate application; in the group 2 (G2) was used subcutenous alendronate (0.5 mg/kg) once for three weeks and then was realizd the both surgical techniques. In group 3 (G3), after ovariectomy was realized the both dental extraction and the calvarium defect and after that was realized the alendronate protocol. In each group, after six week was realized euthanasia and descriptive histological analysis of the surgical areas involved. In bone formation of the 5 mm cranial defect was observed with good progression in the 3 experimental models and no modification in quality of bone repair was observed. For the gingival tissue in the extraction socket, no differences were observed between G1 and G3. On other hand, in G2 a thinner and reduced gingival epithelium was found. Our results showed that alendronate was not an obstacle for bone repair; deficiencies in re-epithelialization of oral mucosa show the impact of alendronate before dental extraction.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.3 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300683en10.4067/S0717-95022020000300683
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Biphosphonate Osteonecrosis Osteoporosis
spellingShingle	Biphosphonate Osteonecrosis Osteoporosis Quinto,José Henrique Santana Sigua-Rodriguez,Eder Alberto Natali,Maria Raquel Marçal Olate,Sergio Cuman,Roberto Kenji Nakamura Farah,Gustavo Jacobucci Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
description	SUMMARY: The aim was to evaluate bone repair and gingival tissue repair in osteopenic rats. Fifteen female wistar rats were included; in all of them ovariectomy was realized to induce osteopenia; after 45 days, the animals were submitted to 2 surgical techinques 1) dental extraction of the upper central incisor with no socket preservation and 2) 5 mm cranial defect in the calvarium; 5 rats were included in the control group (G1) withput alendronate application; in the group 2 (G2) was used subcutenous alendronate (0.5 mg/kg) once for three weeks and then was realizd the both surgical techniques. In group 3 (G3), after ovariectomy was realized the both dental extraction and the calvarium defect and after that was realized the alendronate protocol. In each group, after six week was realized euthanasia and descriptive histological analysis of the surgical areas involved. In bone formation of the 5 mm cranial defect was observed with good progression in the 3 experimental models and no modification in quality of bone repair was observed. For the gingival tissue in the extraction socket, no differences were observed between G1 and G3. On other hand, in G2 a thinner and reduced gingival epithelium was found. Our results showed that alendronate was not an obstacle for bone repair; deficiencies in re-epithelialization of oral mucosa show the impact of alendronate before dental extraction.
author	Quinto,José Henrique Santana Sigua-Rodriguez,Eder Alberto Natali,Maria Raquel Marçal Olate,Sergio Cuman,Roberto Kenji Nakamura Farah,Gustavo Jacobucci
author_facet	Quinto,José Henrique Santana Sigua-Rodriguez,Eder Alberto Natali,Maria Raquel Marçal Olate,Sergio Cuman,Roberto Kenji Nakamura Farah,Gustavo Jacobucci
author_sort	Quinto,José Henrique Santana
title	Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
title_short	Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
title_full	Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
title_fullStr	Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
title_full_unstemmed	Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats
title_sort	effect of alendronate on healing of bone defect and gingival tissue in osteopenic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000300683
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Effect of Alendronate on Healing of Bone Defect and Gingival Tissue in Osteopenic Rats

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