Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits

SUMMARY: Porous titanium alloy scaffold was widely used in treating bone defect caused by traumatic injury and osteomyelitis, which was incapable of self-healing. The implantation of scaffold produced stress shielding thereby forming osteolysis. The objective of this study was to analysis trabecular...

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Autores principales:	Lyu,Linwei, Jing,Ye, Wang,Jikun, Zhang,Chunqiu
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Osseointegration 3D printed porous titanium alloy scaffold preload micro-CT rabbit femoral condyle defect
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000400909
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spelling	oai:scielo:S0717-950220200004009092020-09-08Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in RabbitsLyu,LinweiJing,YeWang,JikunZhang,Chunqiu Osseointegration 3D printed porous titanium alloy scaffold preload micro-CT rabbit femoral condyle defect SUMMARY: Porous titanium alloy scaffold was widely used in treating bone defect caused by traumatic injury and osteomyelitis, which was incapable of self-healing. The implantation of scaffold produced stress shielding thereby forming osteolysis. The objective of this study was to analysis trabecular morphological features of osseointegrated bone. 14 New Zealand rabbits were divided into two groups, surgery group and healthy control group. 7 rabbits in surgery group were selected to perform 3D printed porous titanium alloy scaffold implantation surgery with preload at the defect of femoral condyle for osseointegration. The other 7 rabbits in control group were feed free. After 90 days healing, femoral condyles were extracted to perform micro-CT scanning with hydroxyapatite calibration phantom. Mean bone mineral density (BMD), bone volume fraction (BV/TV), BS/TV (bone surface area ratio), Tb.Th (thickness of trabeculae), Tb.N (number of trabeculae), Tb.Sp (trabecular separation) and DA (degree of anisotropy) were calculated from micro-CT images. The results revealed that osseointegration inside and at the surface of scaffolds worked well from grey values of micro-CT images. After 12 weeks healing, mean bone mineral densities (BMD) in surgery group and healthy control group were calculated as 800±20mg/cm3 and 980±90mg/cm3, respectively. This revealed that the strength of trabeculae in surgery group might lower than that in the healthy group. Trabecular morphological parameters test showed that trabecular morphological parameters at the surface of scaffolds in the surgery group deteriorated significantly. It was found from micro-CT images that ingrowth bone was filled with pores of scaffold. Overall, the effect of osseointegration was promoted through the change of mechanical micro-environment in the scaffold region. Overall, preload could improve osseointegration effect in the long-term after surgery. However, the trabecular morphology in the surgery group was deteriorated, which might bring secondary fracture risk again.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.4 20202020-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000400909en10.4067/S0717-95022020000400909
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Osseointegration 3D printed porous titanium alloy scaffold preload micro-CT rabbit femoral condyle defect
spellingShingle	Osseointegration 3D printed porous titanium alloy scaffold preload micro-CT rabbit femoral condyle defect Lyu,Linwei Jing,Ye Wang,Jikun Zhang,Chunqiu Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
description	SUMMARY: Porous titanium alloy scaffold was widely used in treating bone defect caused by traumatic injury and osteomyelitis, which was incapable of self-healing. The implantation of scaffold produced stress shielding thereby forming osteolysis. The objective of this study was to analysis trabecular morphological features of osseointegrated bone. 14 New Zealand rabbits were divided into two groups, surgery group and healthy control group. 7 rabbits in surgery group were selected to perform 3D printed porous titanium alloy scaffold implantation surgery with preload at the defect of femoral condyle for osseointegration. The other 7 rabbits in control group were feed free. After 90 days healing, femoral condyles were extracted to perform micro-CT scanning with hydroxyapatite calibration phantom. Mean bone mineral density (BMD), bone volume fraction (BV/TV), BS/TV (bone surface area ratio), Tb.Th (thickness of trabeculae), Tb.N (number of trabeculae), Tb.Sp (trabecular separation) and DA (degree of anisotropy) were calculated from micro-CT images. The results revealed that osseointegration inside and at the surface of scaffolds worked well from grey values of micro-CT images. After 12 weeks healing, mean bone mineral densities (BMD) in surgery group and healthy control group were calculated as 800±20mg/cm3 and 980±90mg/cm3, respectively. This revealed that the strength of trabeculae in surgery group might lower than that in the healthy group. Trabecular morphological parameters test showed that trabecular morphological parameters at the surface of scaffolds in the surgery group deteriorated significantly. It was found from micro-CT images that ingrowth bone was filled with pores of scaffold. Overall, the effect of osseointegration was promoted through the change of mechanical micro-environment in the scaffold region. Overall, preload could improve osseointegration effect in the long-term after surgery. However, the trabecular morphology in the surgery group was deteriorated, which might bring secondary fracture risk again.
author	Lyu,Linwei Jing,Ye Wang,Jikun Zhang,Chunqiu
author_facet	Lyu,Linwei Jing,Ye Wang,Jikun Zhang,Chunqiu
author_sort	Lyu,Linwei
title	Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
title_short	Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
title_full	Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
title_fullStr	Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
title_full_unstemmed	Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits
title_sort	enhanced osseointegration of porous titanium scaffold implanted with preload: an experiment study in rabbits
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000400909
work_keys_str_mv	AT lyulinwei enhancedosseointegrationofporoustitaniumscaffoldimplantedwithpreloadanexperimentstudyinrabbits AT jingye enhancedosseointegrationofporoustitaniumscaffoldimplantedwithpreloadanexperimentstudyinrabbits AT wangjikun enhancedosseointegrationofporoustitaniumscaffoldimplantedwithpreloadanexperimentstudyinrabbits AT zhangchunqiu enhancedosseointegrationofporoustitaniumscaffoldimplantedwithpreloadanexperimentstudyinrabbits
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Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits

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