Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole
SUMMARY: Letrozole (Letro) is a drug commonly used for breast cancer treatment since it can decrease estrogen level. In experimental animal, the Letro has been used to induce the polycystic ovarian syndrome (PCOS) model. Tyrosine phosphorylation (TyrPho) is an essential process in various biological...
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Sociedad Chilena de Anatomía
2020
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oai:scielo:S0717-950220200004009192020-09-08Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by LetrozoleChaiyamoon,AradaBunsueb,SudtidaIamsaard,Sitthichai Letrozole Tyrosine phosphorylation Liver Kidney Rats SUMMARY: Letrozole (Letro) is a drug commonly used for breast cancer treatment since it can decrease estrogen level. In experimental animal, the Letro has been used to induce the polycystic ovarian syndrome (PCOS) model. Tyrosine phosphorylation (TyrPho) is an essential process in various biological functions both normal and abnormal conditions especially reproduction. Although some side effects of Letro are reported, the alterations of TyrPho responsible for liver and kidney functions have never been demonstrated. In this study, the blood serum, liver, and kidney of control and PCOS rats induced with Letro (orally, 1 mg/ KgBW) for consecutive 21 days were used to determine the serum biochemical components and to investigate the TyrPho expression using western blot analysis. Histopathology of such tissues was observed by Masson’s trichrome staining. The results showed that Letro did not affect histological structures but significantly increased the serum levels of urea nitrogen, cholesterol, triglyceride, HDL, LDL, ALT, AST, and alkaline phosphatase. Additionally, the TyrPho protein expressions of 32 and 27 kDas in liver and of 55 and 43 kDas in kidney were increased while of a kidney 26 kDa was decreased as compared to those of control. In conclusion, this recent study indicated that the changes of TyrPho proteins in liver and kidney induced with Letro associated with their functions by alteration of serum biochemical levels.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.4 20202020-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000400919en10.4067/S0717-95022020000400919 |
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Scielo Chile |
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Scielo Chile |
| language |
English |
| topic |
Letrozole Tyrosine phosphorylation Liver Kidney Rats |
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Letrozole Tyrosine phosphorylation Liver Kidney Rats Chaiyamoon,Arada Bunsueb,Sudtida Iamsaard,Sitthichai Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| description |
SUMMARY: Letrozole (Letro) is a drug commonly used for breast cancer treatment since it can decrease estrogen level. In experimental animal, the Letro has been used to induce the polycystic ovarian syndrome (PCOS) model. Tyrosine phosphorylation (TyrPho) is an essential process in various biological functions both normal and abnormal conditions especially reproduction. Although some side effects of Letro are reported, the alterations of TyrPho responsible for liver and kidney functions have never been demonstrated. In this study, the blood serum, liver, and kidney of control and PCOS rats induced with Letro (orally, 1 mg/ KgBW) for consecutive 21 days were used to determine the serum biochemical components and to investigate the TyrPho expression using western blot analysis. Histopathology of such tissues was observed by Masson’s trichrome staining. The results showed that Letro did not affect histological structures but significantly increased the serum levels of urea nitrogen, cholesterol, triglyceride, HDL, LDL, ALT, AST, and alkaline phosphatase. Additionally, the TyrPho protein expressions of 32 and 27 kDas in liver and of 55 and 43 kDas in kidney were increased while of a kidney 26 kDa was decreased as compared to those of control. In conclusion, this recent study indicated that the changes of TyrPho proteins in liver and kidney induced with Letro associated with their functions by alteration of serum biochemical levels. |
| author |
Chaiyamoon,Arada Bunsueb,Sudtida Iamsaard,Sitthichai |
| author_facet |
Chaiyamoon,Arada Bunsueb,Sudtida Iamsaard,Sitthichai |
| author_sort |
Chaiyamoon,Arada |
| title |
Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| title_short |
Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| title_full |
Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| title_fullStr |
Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| title_full_unstemmed |
Changes of Tyrosine Phosphorylation in Liver and Kidney of Polycystic Ovarian Rats Induced by Letrozole |
| title_sort |
changes of tyrosine phosphorylation in liver and kidney of polycystic ovarian rats induced by letrozole |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000400919 |
| work_keys_str_mv |
AT chaiyamoonarada changesoftyrosinephosphorylationinliverandkidneyofpolycysticovarianratsinducedbyletrozole AT bunsuebsudtida changesoftyrosinephosphorylationinliverandkidneyofpolycysticovarianratsinducedbyletrozole AT iamsaardsitthichai changesoftyrosinephosphorylationinliverandkidneyofpolycysticovarianratsinducedbyletrozole |
| _version_ |
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