Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma
SUMMARY: Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of...
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Sociedad Chilena de Anatomía
2020
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oai:scielo:S0717-950220200005013922021-06-10Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich PlasmaGarcia,Thiago AlvesOzaki,Guilherme Akio TamuraCastoldi,Robson ChaconJob,Aldo EloizoCamargo,Regina Celi TrindadeFilho,José Carlos Silva CamargoBelangero,William Dias Muscle injury Platelet-rich plasma Suture Collagen SUMMARY: Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of the study will be to analyze the association of suture and PRP techniques in the collagen and tenacity of the injured muscle. Were used seventy rats, divided into five groups: control (C), injury control (CI), injury and suture (IS), injury and PRP (IP), injury, suture, and PRP (ISP). Were sectioned approximately 50 % of the width and 100 % of the thickness of the gastrocnemius muscle. The homologous PRP was applied 24h after the injury. On the 7th day after the injury, the animals were euthanized and their muscles subjected to mechanical testing to measure tenacity or collagen analysis to calculate the ratio between type I and III collagen. The results show a significant decrease (p <0.05) in the values of the relationship between collagens in all injured groups (CI, IS, IP, ISP) compared to group C. In injured groups, the tenacity was significantly (p <0.05) reduced compared to the control group, with no observed difference between treatments and injured groups. The amount of collagen in the injured area has increased, but it did not affect the tenacity of the muscles, which was reduced.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.5 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501392en10.4067/S0717-95022020000501392 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Muscle injury Platelet-rich plasma Suture Collagen |
| spellingShingle |
Muscle injury Platelet-rich plasma Suture Collagen Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Castoldi,Robson Chacon Job,Aldo Eloizo Camargo,Regina Celi Trindade Filho,José Carlos Silva Camargo Belangero,William Dias Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| description |
SUMMARY: Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of the study will be to analyze the association of suture and PRP techniques in the collagen and tenacity of the injured muscle. Were used seventy rats, divided into five groups: control (C), injury control (CI), injury and suture (IS), injury and PRP (IP), injury, suture, and PRP (ISP). Were sectioned approximately 50 % of the width and 100 % of the thickness of the gastrocnemius muscle. The homologous PRP was applied 24h after the injury. On the 7th day after the injury, the animals were euthanized and their muscles subjected to mechanical testing to measure tenacity or collagen analysis to calculate the ratio between type I and III collagen. The results show a significant decrease (p <0.05) in the values of the relationship between collagens in all injured groups (CI, IS, IP, ISP) compared to group C. In injured groups, the tenacity was significantly (p <0.05) reduced compared to the control group, with no observed difference between treatments and injured groups. The amount of collagen in the injured area has increased, but it did not affect the tenacity of the muscles, which was reduced. |
| author |
Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Castoldi,Robson Chacon Job,Aldo Eloizo Camargo,Regina Celi Trindade Filho,José Carlos Silva Camargo Belangero,William Dias |
| author_facet |
Garcia,Thiago Alves Ozaki,Guilherme Akio Tamura Castoldi,Robson Chacon Job,Aldo Eloizo Camargo,Regina Celi Trindade Filho,José Carlos Silva Camargo Belangero,William Dias |
| author_sort |
Garcia,Thiago Alves |
| title |
Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| title_short |
Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| title_full |
Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| title_fullStr |
Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| title_full_unstemmed |
Collagen I and III Ratios and Tenacity of Rats’ Muscle Injured and Treated with Platelet-Rich Plasma |
| title_sort |
collagen i and iii ratios and tenacity of rats’ muscle injured and treated with platelet-rich plasma |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501392 |
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