Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects

SUMMARY: The objective of this study were bone defect complications that occur due to traumas or infections. Bone grafts are required to provide support, fill gaps and improve biological repair in skeletal damage. Dexamethasone plays role in calcium signaling modulation and used in diseases. Aim of...

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Autores principales:	Yigit,Seyhmus, Deveci,Engin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Bone defects Biograft Dexamethasone Osteonectin Osteopontin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501398
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spelling	oai:scielo:S0717-950220200005013982021-06-10Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone DefectsYigit,SeyhmusDeveci,Engin Bone defects Biograft Dexamethasone Osteonectin Osteopontin SUMMARY: The objective of this study were bone defect complications that occur due to traumas or infections. Bone grafts are required to provide support, fill gaps and improve biological repair in skeletal damage. Dexamethasone plays role in calcium signaling modulation and used in diseases. Aim of this study was to evaluate osteonectin and osteopontin expressions in new bone development after dexamethasone application on tibial bone defects. Rats were divided into defect, defect+graft and defect+graft+dexamethasone treated groups. Tibial bone defect created, and rats were kept immobile for 28 days. Alloplastic material was placed in defect area in second and group third groups. 2.5 mg/kg Dex and normal saline were injected to dexamethasone and defect groups twice a week for 56 days. Inflammation and congestion were increased in defect and defect+graft groups. Defect+graft+dexamethasone group; increased number of osteoblast and osteocyte cells, dense bone matrix, formation of new bone trabeculae was observed. Defect+graft group; osteonectin expression in graft regions, osteoblast cells, some connective tissue cells and fibers were seen whereas in defect+graft+dexamethasone group; osteopontin expression in osteoblast and osteocyte cells of new bone trabeculae were observed. Dexamethasone may lead to formation of new bone trabeculae into the graft material resulting in increased osteoconduction and osteoinductive effect for differentiation of osteon.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.5 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501398en10.4067/S0717-95022020000501398
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bone defects Biograft Dexamethasone Osteonectin Osteopontin
spellingShingle	Bone defects Biograft Dexamethasone Osteonectin Osteopontin Yigit,Seyhmus Deveci,Engin Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
description	SUMMARY: The objective of this study were bone defect complications that occur due to traumas or infections. Bone grafts are required to provide support, fill gaps and improve biological repair in skeletal damage. Dexamethasone plays role in calcium signaling modulation and used in diseases. Aim of this study was to evaluate osteonectin and osteopontin expressions in new bone development after dexamethasone application on tibial bone defects. Rats were divided into defect, defect+graft and defect+graft+dexamethasone treated groups. Tibial bone defect created, and rats were kept immobile for 28 days. Alloplastic material was placed in defect area in second and group third groups. 2.5 mg/kg Dex and normal saline were injected to dexamethasone and defect groups twice a week for 56 days. Inflammation and congestion were increased in defect and defect+graft groups. Defect+graft+dexamethasone group; increased number of osteoblast and osteocyte cells, dense bone matrix, formation of new bone trabeculae was observed. Defect+graft group; osteonectin expression in graft regions, osteoblast cells, some connective tissue cells and fibers were seen whereas in defect+graft+dexamethasone group; osteopontin expression in osteoblast and osteocyte cells of new bone trabeculae were observed. Dexamethasone may lead to formation of new bone trabeculae into the graft material resulting in increased osteoconduction and osteoinductive effect for differentiation of osteon.
author	Yigit,Seyhmus Deveci,Engin
author_facet	Yigit,Seyhmus Deveci,Engin
author_sort	Yigit,Seyhmus
title	Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
title_short	Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
title_full	Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
title_fullStr	Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
title_full_unstemmed	Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects
title_sort	graft application and dexamethasone treatment influences new bone formation in rat tibial bone defects
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501398
work_keys_str_mv	AT yigitseyhmus graftapplicationanddexamethasonetreatmentinfluencesnewboneformationinrattibialbonedefects AT deveciengin graftapplicationanddexamethasonetreatmentinfluencesnewboneformationinrattibialbonedefects
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Graft Application and Dexamethasone Treatment Influences New Bone Formation in Rat Tibial Bone Defects

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