Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2

SUMMARY: Bone morphogenetic protein (rhBMP-2) is a powerful osteo-inductive growth factor widely used in bone reconstruction and both the vehicle used to administer it and the scaffold substrate could determine its success in clinical situations. The aim was to analyse the clinical behaviour of dent...

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Autores principales:	Maître,Gustavo, Farias,Daniel, de-Moraes,Eduardo, Sacco,Roberto, Ball,Rebecca, Haidar,Ziyad S, Olate,Sergio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	rhBMP-2 hydroxyapatite osteoinduction bone graft
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501426
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spelling	oai:scielo:S0717-950220200005014262021-06-10Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2Maître,GustavoFarias,Danielde-Moraes,EduardoSacco,RobertoBall,RebeccaHaidar,Ziyad SOlate,Sergio rhBMP-2 hydroxyapatite osteoinduction bone graft SUMMARY: Bone morphogenetic protein (rhBMP-2) is a powerful osteo-inductive growth factor widely used in bone reconstruction and both the vehicle used to administer it and the scaffold substrate could determine its success in clinical situations. The aim was to analyse the clinical behaviour of dental implants placed in single alveolar ridges with a horizontal deficiency in the maxillary anterior region that were reconstructed horizontally with rhBMP-2 and porous hydroxyapatite (HA). Inclusion criteria were both males and females, between the ages of 18 and 29 with single tooth loss of one upper incisor. Cone Beam Computed Tomography (CBCT) was used to take measurements prior to bone augmentation and again prior to the implant insertion. Surgery was carried out under local anaesthetic. In the primary procedure, bone substitute was introduced using porous HA and rhBMP-2; after 4 to 5 months, dental implant surgery was carried out and the implant placed; after 3 months of consolidation the provisional prosthesis was placed and then a definitive restoration was placed. Variables were analysed using the t-test with a p-value of < 0.05 in order to assess statistical significance. Thirteen subjects were included (6 females and 7 males). Bone augmentation resulted in a bone gain of 4.15mm (p=0.023), which was shown to be statistically significant. All of the grafts placed were successful and 13 implants were placed, using torques between 30 and 70N, without complications. For the final prostheses, 11 were screw retained and 2 were cemented in place. The horizontal bone augmentation using HA and rhBMP-2 is an efficient technique for single bone defects in the anterior maxillary area; clinical trials on a larger scale are needed to confirm these results.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.5 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501426en10.4067/S0717-95022020000501426
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	rhBMP-2 hydroxyapatite osteoinduction bone graft
spellingShingle	rhBMP-2 hydroxyapatite osteoinduction bone graft Maître,Gustavo Farias,Daniel de-Moraes,Eduardo Sacco,Roberto Ball,Rebecca Haidar,Ziyad S Olate,Sergio Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
description	SUMMARY: Bone morphogenetic protein (rhBMP-2) is a powerful osteo-inductive growth factor widely used in bone reconstruction and both the vehicle used to administer it and the scaffold substrate could determine its success in clinical situations. The aim was to analyse the clinical behaviour of dental implants placed in single alveolar ridges with a horizontal deficiency in the maxillary anterior region that were reconstructed horizontally with rhBMP-2 and porous hydroxyapatite (HA). Inclusion criteria were both males and females, between the ages of 18 and 29 with single tooth loss of one upper incisor. Cone Beam Computed Tomography (CBCT) was used to take measurements prior to bone augmentation and again prior to the implant insertion. Surgery was carried out under local anaesthetic. In the primary procedure, bone substitute was introduced using porous HA and rhBMP-2; after 4 to 5 months, dental implant surgery was carried out and the implant placed; after 3 months of consolidation the provisional prosthesis was placed and then a definitive restoration was placed. Variables were analysed using the t-test with a p-value of < 0.05 in order to assess statistical significance. Thirteen subjects were included (6 females and 7 males). Bone augmentation resulted in a bone gain of 4.15mm (p=0.023), which was shown to be statistically significant. All of the grafts placed were successful and 13 implants were placed, using torques between 30 and 70N, without complications. For the final prostheses, 11 were screw retained and 2 were cemented in place. The horizontal bone augmentation using HA and rhBMP-2 is an efficient technique for single bone defects in the anterior maxillary area; clinical trials on a larger scale are needed to confirm these results.
author	Maître,Gustavo Farias,Daniel de-Moraes,Eduardo Sacco,Roberto Ball,Rebecca Haidar,Ziyad S Olate,Sergio
author_facet	Maître,Gustavo Farias,Daniel de-Moraes,Eduardo Sacco,Roberto Ball,Rebecca Haidar,Ziyad S Olate,Sergio
author_sort	Maître,Gustavo
title	Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
title_short	Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
title_full	Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
title_fullStr	Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
title_full_unstemmed	Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2
title_sort	horizontal ridge augmentation of a single atrophic site in the anterior maxilla using hydroxyapatite and rhbmp-2
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501426
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Horizontal Ridge Augmentation of a Single Atrophic Site in the Anterior Maxilla Using Hydroxyapatite and rhBMP-2

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