Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats

SUMMARY: This study aimed to investigate the changes in testis tissue of thioacetamide-induced rats and the effect of melatonin on these changes. Thirty-five male Wistar Albino rats were divided into five groups. Group I; Control (n=7), Group II; Melatonin (Mel) (10 mg/kg) a single dose (i.p)(n=7),...

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Autores principales:	Karabulut,Derya, Akın,Ali Tugrul, Sayan,Meryem, Kaymak,Emin, Ozturk,Emel, Yakan,Birkan
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Thioacetamide Melatonin Heat shock proteins Testis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501455
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spelling	oai:scielo:S0717-950220200005014552021-06-10Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in RatsKarabulut,DeryaAkın,Ali TugrulSayan,MeryemKaymak,EminOzturk,EmelYakan,Birkan Thioacetamide Melatonin Heat shock proteins Testis SUMMARY: This study aimed to investigate the changes in testis tissue of thioacetamide-induced rats and the effect of melatonin on these changes. Thirty-five male Wistar Albino rats were divided into five groups. Group I; Control (n=7), Group II; Melatonin (Mel) (10 mg/kg) a single dose (i.p)(n=7), Group III; Thioacetamide (TAA) (300 mg/kg) (i.p) 2 times with 24 hour intervals (n=7), Group IV; TAA (300 mg/kg) was administered at 24-hour intervals, afterwards of 10 mg/kg single dose of Mel (n=7), Group V; Mel was administered 10 mg/kg a single dose 24 hours before the administration of TAA (n=7). Testis was evaluated histologically, immunohistochemically (Heat Shock Proteins (HSP) 70 and 90), blood serum testosterone, total antioxidant status(TAS) and total oxidant status(TOS) in tissue. The tissue sections of Group III decreased seminiferous tubule diameters, and germinal epithelium spills were observed. HSP70 and HSP90 expressions were increased. There wasn’t a statistically significant change in testosterone levels among the groups. While TAS levels decreased in Group III compared to control, TOS levels didn’t change. HSP70 and HSP90 decreased in groups with Mel-treated. Mel was found to have both protective and therapeutic effects. According to our results, the therapeutic effect of Mel in thioacetamide-induced acute testicular injury is greater than its protective effect.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.5 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501455en10.4067/S0717-95022020000501455
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thioacetamide Melatonin Heat shock proteins Testis
spellingShingle	Thioacetamide Melatonin Heat shock proteins Testis Karabulut,Derya Akın,Ali Tugrul Sayan,Meryem Kaymak,Emin Ozturk,Emel Yakan,Birkan Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
description	SUMMARY: This study aimed to investigate the changes in testis tissue of thioacetamide-induced rats and the effect of melatonin on these changes. Thirty-five male Wistar Albino rats were divided into five groups. Group I; Control (n=7), Group II; Melatonin (Mel) (10 mg/kg) a single dose (i.p)(n=7), Group III; Thioacetamide (TAA) (300 mg/kg) (i.p) 2 times with 24 hour intervals (n=7), Group IV; TAA (300 mg/kg) was administered at 24-hour intervals, afterwards of 10 mg/kg single dose of Mel (n=7), Group V; Mel was administered 10 mg/kg a single dose 24 hours before the administration of TAA (n=7). Testis was evaluated histologically, immunohistochemically (Heat Shock Proteins (HSP) 70 and 90), blood serum testosterone, total antioxidant status(TAS) and total oxidant status(TOS) in tissue. The tissue sections of Group III decreased seminiferous tubule diameters, and germinal epithelium spills were observed. HSP70 and HSP90 expressions were increased. There wasn’t a statistically significant change in testosterone levels among the groups. While TAS levels decreased in Group III compared to control, TOS levels didn’t change. HSP70 and HSP90 decreased in groups with Mel-treated. Mel was found to have both protective and therapeutic effects. According to our results, the therapeutic effect of Mel in thioacetamide-induced acute testicular injury is greater than its protective effect.
author	Karabulut,Derya Akın,Ali Tugrul Sayan,Meryem Kaymak,Emin Ozturk,Emel Yakan,Birkan
author_facet	Karabulut,Derya Akın,Ali Tugrul Sayan,Meryem Kaymak,Emin Ozturk,Emel Yakan,Birkan
author_sort	Karabulut,Derya
title	Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
title_short	Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
title_full	Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
title_fullStr	Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
title_full_unstemmed	Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats
title_sort	effects of melatonin against thioacetamide-induced testicular toxicity in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000501455
work_keys_str_mv	AT karabulutderya effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats AT ak305nalitugrul effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats AT sayanmeryem effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats AT kaymakemin effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats AT ozturkemel effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats AT yakanbirkan effectsofmelatoninagainstthioacetamideinducedtesticulartoxicityinrats
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Effects of Melatonin Against Thioacetamide-Induced Testicular Toxicity in Rats

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