Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice

SUMMARY: This study aims to investigate the Effects of Titanium dioxide nanoparticles (TiO2 NPs) on the stereological parameters in the dentate gyrus and the morphology of granular hippocampal neurons in adult mice. Adult male mice (n=20, weight average: 45 g) were randomly divided into four groups...

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Autores principales:	Rahnama,Sharare, Hassanpour,Azam, Yadegari,Maryam, Anvari,Morteza, Hosseini-sharifabad,Mohammad
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	TiO2 Stereology Hippocampus Dentate gyrus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601623
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spelling	oai:scielo:S0717-950220200006016232020-10-30Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in MiceRahnama,SharareHassanpour,AzamYadegari,MaryamAnvari,MortezaHosseini-sharifabad,Mohammad TiO2 Stereology Hippocampus Dentate gyrus SUMMARY: This study aims to investigate the Effects of Titanium dioxide nanoparticles (TiO2 NPs) on the stereological parameters in the dentate gyrus and the morphology of granular hippocampal neurons in adult mice. Adult male mice (n=20, weight average: 45 g) were randomly divided into four groups including: group receiving saline (controls), low-dose (LD) 2.5 mg/kg TiO TiO2 NPs, medium-dose (MD) 5 mg/kg TiO2 NPs and high-dose (HD) 10 mg/kg TiO2 NPs, daily using gavage for 35 days. To estimate the volume of the hippocampus, dentate gyrus, and sub-layers of dentate gyrus the Cavalieri principle was used. The physical dissector was used to determine the numerical density of dentate gyrus granular cells. For analyzing the morphology of dentate gyrus granular cells the qualitative Golgi staining was used. Our data showed that the total volume of the hippocampus, dentate gyrus and its sublayers including molecular, granular and polymorph in TiO2 treated mice decreased significantly compared to the control group. Moreover, the total number and numerical density of dentate gyrus granular sub layer cells showed a significant reduction in all three experimental groups compared to the control group. The granular cells of the dentate gyrus had shorter dendritic length and decreased dendritic branches in the TiO2-treated in comparison with the control mice. These data can justify the disorders related to memory, learning and hippocampus neurons damages due to using of TiO2 NPs.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.6 20202020-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601623en10.4067/S0717-95022020000601623
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	TiO2 Stereology Hippocampus Dentate gyrus
spellingShingle	TiO2 Stereology Hippocampus Dentate gyrus Rahnama,Sharare Hassanpour,Azam Yadegari,Maryam Anvari,Morteza Hosseini-sharifabad,Mohammad Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
description	SUMMARY: This study aims to investigate the Effects of Titanium dioxide nanoparticles (TiO2 NPs) on the stereological parameters in the dentate gyrus and the morphology of granular hippocampal neurons in adult mice. Adult male mice (n=20, weight average: 45 g) were randomly divided into four groups including: group receiving saline (controls), low-dose (LD) 2.5 mg/kg TiO TiO2 NPs, medium-dose (MD) 5 mg/kg TiO2 NPs and high-dose (HD) 10 mg/kg TiO2 NPs, daily using gavage for 35 days. To estimate the volume of the hippocampus, dentate gyrus, and sub-layers of dentate gyrus the Cavalieri principle was used. The physical dissector was used to determine the numerical density of dentate gyrus granular cells. For analyzing the morphology of dentate gyrus granular cells the qualitative Golgi staining was used. Our data showed that the total volume of the hippocampus, dentate gyrus and its sublayers including molecular, granular and polymorph in TiO2 treated mice decreased significantly compared to the control group. Moreover, the total number and numerical density of dentate gyrus granular sub layer cells showed a significant reduction in all three experimental groups compared to the control group. The granular cells of the dentate gyrus had shorter dendritic length and decreased dendritic branches in the TiO2-treated in comparison with the control mice. These data can justify the disorders related to memory, learning and hippocampus neurons damages due to using of TiO2 NPs.
author	Rahnama,Sharare Hassanpour,Azam Yadegari,Maryam Anvari,Morteza Hosseini-sharifabad,Mohammad
author_facet	Rahnama,Sharare Hassanpour,Azam Yadegari,Maryam Anvari,Morteza Hosseini-sharifabad,Mohammad
author_sort	Rahnama,Sharare
title	Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
title_short	Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
title_full	Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
title_fullStr	Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
title_full_unstemmed	Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice
title_sort	effect of titanium dioxide nanoparticles on the stereological parameters of the dentate gyrus and the morphology of granular hippocampal neurons in mice
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601623
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Effect of Titanium Dioxide Nanoparticles on the Stereological Parameters of the Dentate Gyrus and the Morphology of Granular Hippocampal Neurons in Mice

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