Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats

SUMMARY: Herbal extracts used for treatment of diabetes has focused mostly on the hypoglycaemic and anti-oxidant property.There are no studies which focused on its effect on dendritic architecture of pyramidal neurons of hippocampus caused by diabetes. This study was taken up to explore the effect o...

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Autores principales:	Kodumuri,Praveen Kumar, Pandey,Anil Kumar, Thomas,Christofer
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Diabetes Dendritic atrophy Fenugreek Hippocampus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601693
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spelling	oai:scielo:S0717-950220200006016932020-10-30Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic RatsKodumuri,Praveen KumarPandey,Anil KumarThomas,Christofer Diabetes Dendritic atrophy Fenugreek Hippocampus SUMMARY: Herbal extracts used for treatment of diabetes has focused mostly on the hypoglycaemic and anti-oxidant property.There are no studies which focused on its effect on dendritic architecture of pyramidal neurons of hippocampus caused by diabetes. This study was taken up to explore the effect of administration of Trigonella foenum-graecum (fenugreek) seed extract on diabetes induced dendritic atrophy in hippocampus. Experimental diabetes was induced in rats by administering single dose of Streptozotocin (60 mg/kg)intraperitoneally.Treatment groups of rats were orally administeredfenugreek seed extract of 1 g/kg body weight for 6 weeks. Followingly they were sacrificed and the brains were removed, processed for the Golgi-Cox stain method.The number of dendritic branching points and intersections were counted in successive radial segments of 20 µm up to a radial distance of 100 micron from soma and analysed by the Sholl’s method. The rats with diabetes showed a significant decrease in the dendritic length and branching points in most of the apical and basal dendrites of CA1 and CA3 pyramidal neurons.Treatment with fenugreek seed extract were able to significantly alleviate the dendritic atrophy in most of the segments except in the apical branching points of the CA1 neuron. The present study demonstrates that fenugreek seed extract having a proven hypoglycaemic and anti-diabetic property also possess protection to the hippocampal pyramidal neurons form diabetes associated neuronal atrophy.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.6 20202020-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601693en10.4067/S0717-95022020000601693
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes Dendritic atrophy Fenugreek Hippocampus
spellingShingle	Diabetes Dendritic atrophy Fenugreek Hippocampus Kodumuri,Praveen Kumar Pandey,Anil Kumar Thomas,Christofer Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
description	SUMMARY: Herbal extracts used for treatment of diabetes has focused mostly on the hypoglycaemic and anti-oxidant property.There are no studies which focused on its effect on dendritic architecture of pyramidal neurons of hippocampus caused by diabetes. This study was taken up to explore the effect of administration of Trigonella foenum-graecum (fenugreek) seed extract on diabetes induced dendritic atrophy in hippocampus. Experimental diabetes was induced in rats by administering single dose of Streptozotocin (60 mg/kg)intraperitoneally.Treatment groups of rats were orally administeredfenugreek seed extract of 1 g/kg body weight for 6 weeks. Followingly they were sacrificed and the brains were removed, processed for the Golgi-Cox stain method.The number of dendritic branching points and intersections were counted in successive radial segments of 20 µm up to a radial distance of 100 micron from soma and analysed by the Sholl’s method. The rats with diabetes showed a significant decrease in the dendritic length and branching points in most of the apical and basal dendrites of CA1 and CA3 pyramidal neurons.Treatment with fenugreek seed extract were able to significantly alleviate the dendritic atrophy in most of the segments except in the apical branching points of the CA1 neuron. The present study demonstrates that fenugreek seed extract having a proven hypoglycaemic and anti-diabetic property also possess protection to the hippocampal pyramidal neurons form diabetes associated neuronal atrophy.
author	Kodumuri,Praveen Kumar Pandey,Anil Kumar Thomas,Christofer
author_facet	Kodumuri,Praveen Kumar Pandey,Anil Kumar Thomas,Christofer
author_sort	Kodumuri,Praveen Kumar
title	Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
title_short	Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
title_full	Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
title_fullStr	Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
title_full_unstemmed	Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats
title_sort	fenugreek seed extract alleviates hippocampal dendritic atrophy in streptozotocin induced diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601693
work_keys_str_mv	AT kodumuripraveenkumar fenugreekseedextractalleviateshippocampaldendriticatrophyinstreptozotocininduceddiabeticrats AT pandeyanilkumar fenugreekseedextractalleviateshippocampaldendriticatrophyinstreptozotocininduceddiabeticrats AT thomaschristofer fenugreekseedextractalleviateshippocampaldendriticatrophyinstreptozotocininduceddiabeticrats
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Fenugreek Seed Extract Alleviates Hippocampal Dendritic Atrophy in Streptozotocin Induced Diabetic Rats

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