Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes

SUMMARY: The treatment of chronic wounds has become a public health issue in recent years mainly due to comorbidities associated with an older population and bacterial resistance. Honey has emerged as an alternative treatment for chronic wounds but lack of knowledge of its mechanism of actionin the...

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Autores principales:	Muñoz,Mariela, Vásquez,Bélgica, del Sol,Mariano
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Wound healing Re-epithelialization Keratinocytes Honey
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601700
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spelling	oai:scielo:S0717-950220200006017002020-10-30Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in KeratinocytesMuñoz,MarielaVásquez,Bélgicadel Sol,Mariano Wound healing Re-epithelialization Keratinocytes Honey SUMMARY: The treatment of chronic wounds has become a public health issue in recent years mainly due to comorbidities associated with an older population and bacterial resistance. Honey has emerged as an alternative treatment for chronic wounds but lack of knowledge of its mechanism of actionin the treated tissue and low quality of evidence in clinical triads has distanced the medical community from honey as a possible treatment. One of the main processes that is altered in chronic wounds is re-epithelialization mediated by keratinocytes, where proliferation and migration processes are altered. Markers of proliferation, migration and activation of keratinocytes, such as adhesion molecules, growth factors, membrane receptors, signal translating proteins, transcription factors, microRNAs, among others are deregulated in this process. In general, honeys from different floral origins have a positive effect on markers of proliferation and migration in keratinocytes. In conclusion there are still few studies that focus on the molecular action of honey in keratinocytes and fail to report details on the honey used not allowing to achieve the same results.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.6 20202020-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601700en10.4067/S0717-95022020000601700
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Wound healing Re-epithelialization Keratinocytes Honey
spellingShingle	Wound healing Re-epithelialization Keratinocytes Honey Muñoz,Mariela Vásquez,Bélgica del Sol,Mariano Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
description	SUMMARY: The treatment of chronic wounds has become a public health issue in recent years mainly due to comorbidities associated with an older population and bacterial resistance. Honey has emerged as an alternative treatment for chronic wounds but lack of knowledge of its mechanism of actionin the treated tissue and low quality of evidence in clinical triads has distanced the medical community from honey as a possible treatment. One of the main processes that is altered in chronic wounds is re-epithelialization mediated by keratinocytes, where proliferation and migration processes are altered. Markers of proliferation, migration and activation of keratinocytes, such as adhesion molecules, growth factors, membrane receptors, signal translating proteins, transcription factors, microRNAs, among others are deregulated in this process. In general, honeys from different floral origins have a positive effect on markers of proliferation and migration in keratinocytes. In conclusion there are still few studies that focus on the molecular action of honey in keratinocytes and fail to report details on the honey used not allowing to achieve the same results.
author	Muñoz,Mariela Vásquez,Bélgica del Sol,Mariano
author_facet	Muñoz,Mariela Vásquez,Bélgica del Sol,Mariano
author_sort	Muñoz,Mariela
title	Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
title_short	Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
title_full	Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
title_fullStr	Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
title_full_unstemmed	Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes
title_sort	molecular mechanisms in the process of re-epithelization in wound healing and the action of honey in keratinocytes
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000601700
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Molecular Mechanisms in the Process of Re-epithelization in Wound Healing and the Action of Honey in Keratinocytes

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