Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in smal...
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Sociedad Chilena de Anatomía
2021
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oai:scielo:S0717-950220210002003712021-04-22Small Bronchiolar Histopathological Changes Related to Prolonged DiabetesChookliang,AmornratLanlua,PassaraNiyomchan,ApichayaSricharoenvej,Sirinush Lung Small bronchiole Chronic diabetes Streptozotocin SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bronchioles in streptozotocin (STZ)-induced chronic diabetes were determined. Twenty-four weeks after STZ induction, rats were sacrificed, and the right and left lungs were collected for examination by light and electron microscopy. The alterations to the small bronchioles were the same in both lungs of these diabetic rats. The bronchiolar epithelial cells, both ciliated and secretory club cells, showed pyknotic nuclei and damaged cytoplasmic organelles. Increased thickening of the bronchiolar wall occurred in diabetic rats due to smooth muscle layer thickening, inflammatory cell infiltration, and increased numbers of myofibroblasts with collagen deposition.These results indicated that chronic diabetes caused extreme damage to small bronchioles, which may lead to chronic small airway obstruction and ultimately increase the likelihood of COPD progression. This basic knowledge provides a better understanding of the progression of pathogenesis in the small airways of patients with prolonged diabetes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200371en10.4067/S0717-95022021000200371 |
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Scielo Chile |
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Scielo Chile |
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English |
topic |
Lung Small bronchiole Chronic diabetes Streptozotocin |
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Lung Small bronchiole Chronic diabetes Streptozotocin Chookliang,Amornrat Lanlua,Passara Niyomchan,Apichaya Sricharoenvej,Sirinush Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
description |
SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bronchioles in streptozotocin (STZ)-induced chronic diabetes were determined. Twenty-four weeks after STZ induction, rats were sacrificed, and the right and left lungs were collected for examination by light and electron microscopy. The alterations to the small bronchioles were the same in both lungs of these diabetic rats. The bronchiolar epithelial cells, both ciliated and secretory club cells, showed pyknotic nuclei and damaged cytoplasmic organelles. Increased thickening of the bronchiolar wall occurred in diabetic rats due to smooth muscle layer thickening, inflammatory cell infiltration, and increased numbers of myofibroblasts with collagen deposition.These results indicated that chronic diabetes caused extreme damage to small bronchioles, which may lead to chronic small airway obstruction and ultimately increase the likelihood of COPD progression. This basic knowledge provides a better understanding of the progression of pathogenesis in the small airways of patients with prolonged diabetes. |
author |
Chookliang,Amornrat Lanlua,Passara Niyomchan,Apichaya Sricharoenvej,Sirinush |
author_facet |
Chookliang,Amornrat Lanlua,Passara Niyomchan,Apichaya Sricharoenvej,Sirinush |
author_sort |
Chookliang,Amornrat |
title |
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
title_short |
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
title_full |
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
title_fullStr |
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
title_full_unstemmed |
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes |
title_sort |
small bronchiolar histopathological changes related to prolonged diabetes |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2021 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200371 |
work_keys_str_mv |
AT chookliangamornrat smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes AT lanluapassara smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes AT niyomchanapichaya smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes AT sricharoenvejsirinush smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes |
_version_ |
1718445187907190784 |