Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes

SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in smal...

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Autores principales: Chookliang,Amornrat, Lanlua,Passara, Niyomchan,Apichaya, Sricharoenvej,Sirinush
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2021
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200371
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spelling oai:scielo:S0717-950220210002003712021-04-22Small Bronchiolar Histopathological Changes Related to Prolonged DiabetesChookliang,AmornratLanlua,PassaraNiyomchan,ApichayaSricharoenvej,Sirinush Lung Small bronchiole Chronic diabetes Streptozotocin SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bronchioles in streptozotocin (STZ)-induced chronic diabetes were determined. Twenty-four weeks after STZ induction, rats were sacrificed, and the right and left lungs were collected for examination by light and electron microscopy. The alterations to the small bronchioles were the same in both lungs of these diabetic rats. The bronchiolar epithelial cells, both ciliated and secretory club cells, showed pyknotic nuclei and damaged cytoplasmic organelles. Increased thickening of the bronchiolar wall occurred in diabetic rats due to smooth muscle layer thickening, inflammatory cell infiltration, and increased numbers of myofibroblasts with collagen deposition.These results indicated that chronic diabetes caused extreme damage to small bronchioles, which may lead to chronic small airway obstruction and ultimately increase the likelihood of COPD progression. This basic knowledge provides a better understanding of the progression of pathogenesis in the small airways of patients with prolonged diabetes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200371en10.4067/S0717-95022021000200371
institution Scielo Chile
collection Scielo Chile
language English
topic Lung
Small bronchiole
Chronic diabetes
Streptozotocin
spellingShingle Lung
Small bronchiole
Chronic diabetes
Streptozotocin
Chookliang,Amornrat
Lanlua,Passara
Niyomchan,Apichaya
Sricharoenvej,Sirinush
Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
description SUMMARY: Diabetes mellitus increases the risk of developing chronic obstructive pulmonary disease (COPD). The small bronchiole is a prominent site of airflow obstruction that causes increased airway resistance in patients with the COPD. Therefore, the histological and ultrastructural changes in small bronchioles in streptozotocin (STZ)-induced chronic diabetes were determined. Twenty-four weeks after STZ induction, rats were sacrificed, and the right and left lungs were collected for examination by light and electron microscopy. The alterations to the small bronchioles were the same in both lungs of these diabetic rats. The bronchiolar epithelial cells, both ciliated and secretory club cells, showed pyknotic nuclei and damaged cytoplasmic organelles. Increased thickening of the bronchiolar wall occurred in diabetic rats due to smooth muscle layer thickening, inflammatory cell infiltration, and increased numbers of myofibroblasts with collagen deposition.These results indicated that chronic diabetes caused extreme damage to small bronchioles, which may lead to chronic small airway obstruction and ultimately increase the likelihood of COPD progression. This basic knowledge provides a better understanding of the progression of pathogenesis in the small airways of patients with prolonged diabetes.
author Chookliang,Amornrat
Lanlua,Passara
Niyomchan,Apichaya
Sricharoenvej,Sirinush
author_facet Chookliang,Amornrat
Lanlua,Passara
Niyomchan,Apichaya
Sricharoenvej,Sirinush
author_sort Chookliang,Amornrat
title Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
title_short Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
title_full Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
title_fullStr Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
title_full_unstemmed Small Bronchiolar Histopathological Changes Related to Prolonged Diabetes
title_sort small bronchiolar histopathological changes related to prolonged diabetes
publisher Sociedad Chilena de Anatomía
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200371
work_keys_str_mv AT chookliangamornrat smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes
AT lanluapassara smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes
AT niyomchanapichaya smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes
AT sricharoenvejsirinush smallbronchiolarhistopathologicalchangesrelatedtoprolongeddiabetes
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