Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion

SUMMARY: Renal ischemia-reperfusion injury (IRI)is an unavoidable consequence in renal transplantation and multiple clinical settings. A debate has been raised about the particular role of hypoxia-inducible factor (HF-1α) in the renal injury pathogenesis and the renal cortex ultrastructural...

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Autores principales:	Ashour,Hend, Rashed,Laila, Elkordy,Miran Atif, Abdelwahed,Omaima Mohammed
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Ischemia-reperfusion injury Renal HIF-1a Thymoquinone
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200469
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spelling	oai:scielo:S0717-950220210002004692021-04-22Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-ReperfusionAshour,HendRashed,LailaElkordy,Miran AtifAbdelwahed,Omaima Mohammed Ischemia-reperfusion injury Renal HIF-1a Thymoquinone SUMMARY: Renal ischemia-reperfusion injury (IRI)is an unavoidable consequence in renal transplantation and multiple clinical settings. A debate has been raised about the particular role of hypoxia-inducible factor (HF-1α) in the renal injury pathogenesis and the renal cortex ultrastructural alterations. Also, we investigated the antioxidant/anti-inflammatory effect of thymoquinone and its modulatory role on HIF-1α in protection against renal IRI.Adult male Wister albino rats were assigned into 3 groups (n=16); 1) Sham-operated, 2) IRI model and 3) renal IRI pre-treated with thymoquinone 10 mg.kg-1.day-1 (TQ-IRI) for 10 days and at the reperfusion onset. Following the operation, 8 rats from each group were euthanized after 3 hours and the remaining 8 rats at 24 hours. Renal injury was assessed by the increased blood urea nitrogen, creatinine level, and the EGTI histological injury scoreat both 3 and 24h. HIF-1α was upregulated (p<0.01) and was correlated with renal tissue reactive oxygen species (ROS) production and total oxidant capacity (TAC) consumption. Elevated inflammatory markers (NFkB, MCP-1 and VCAM-1) were associated with renal IRI.Thymoquinone treatment inhibited the accumulation of HIF-1α (p<0.01), reduced renal oxidation/inflammation process and markedly diminished renal injury.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200469en10.4067/S0717-95022021000200469
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ischemia-reperfusion injury Renal HIF-1a Thymoquinone
spellingShingle	Ischemia-reperfusion injury Renal HIF-1a Thymoquinone Ashour,Hend Rashed,Laila Elkordy,Miran Atif Abdelwahed,Omaima Mohammed Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
description	SUMMARY: Renal ischemia-reperfusion injury (IRI)is an unavoidable consequence in renal transplantation and multiple clinical settings. A debate has been raised about the particular role of hypoxia-inducible factor (HF-1α) in the renal injury pathogenesis and the renal cortex ultrastructural alterations. Also, we investigated the antioxidant/anti-inflammatory effect of thymoquinone and its modulatory role on HIF-1α in protection against renal IRI.Adult male Wister albino rats were assigned into 3 groups (n=16); 1) Sham-operated, 2) IRI model and 3) renal IRI pre-treated with thymoquinone 10 mg.kg-1.day-1 (TQ-IRI) for 10 days and at the reperfusion onset. Following the operation, 8 rats from each group were euthanized after 3 hours and the remaining 8 rats at 24 hours. Renal injury was assessed by the increased blood urea nitrogen, creatinine level, and the EGTI histological injury scoreat both 3 and 24h. HIF-1α was upregulated (p<0.01) and was correlated with renal tissue reactive oxygen species (ROS) production and total oxidant capacity (TAC) consumption. Elevated inflammatory markers (NFkB, MCP-1 and VCAM-1) were associated with renal IRI.Thymoquinone treatment inhibited the accumulation of HIF-1α (p<0.01), reduced renal oxidation/inflammation process and markedly diminished renal injury.
author	Ashour,Hend Rashed,Laila Elkordy,Miran Atif Abdelwahed,Omaima Mohammed
author_facet	Ashour,Hend Rashed,Laila Elkordy,Miran Atif Abdelwahed,Omaima Mohammed
author_sort	Ashour,Hend
title	Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
title_short	Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
title_full	Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
title_fullStr	Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
title_full_unstemmed	Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion
title_sort	thymoquinone ameliorates acute kidney injury induced by renal ischemia-reperfusion
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200469
work_keys_str_mv	AT ashourhend thymoquinoneamelioratesacutekidneyinjuryinducedbyrenalischemiareperfusion AT rashedlaila thymoquinoneamelioratesacutekidneyinjuryinducedbyrenalischemiareperfusion AT elkordymiranatif thymoquinoneamelioratesacutekidneyinjuryinducedbyrenalischemiareperfusion AT abdelwahedomaimamohammed thymoquinoneamelioratesacutekidneyinjuryinducedbyrenalischemiareperfusion
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Thymoquinone Ameliorates Acute Kidney Injury Induced by Renal Ischemia-Reperfusion

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