Stereological Quantification of Extraocular Muscles in Humans

SUMMARY: The aim of this study is to quantify muscular and connective tissue volumes of extraocular muscles (EOM) in humans with no ophthalmological disease using stereology. EOM from five cadaveric non-strabismic humans were obtained. The number of muscle fibers in 5,000 µm2 and volume density (Vv)...

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Autores principales:	San-Martín,J, Luna,C, Garretón,R, Araneda,S, Salgado,C, Rodríguez,A, Salgado,G
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Oculomotor muscles Humans Histology Anatomy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200506
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spelling	oai:scielo:S0717-950220210002005062021-04-22Stereological Quantification of Extraocular Muscles in HumansSan-Martín,JLuna,CGarretón,RAraneda,SSalgado,CRodríguez,ASalgado,G Oculomotor muscles Humans Histology Anatomy SUMMARY: The aim of this study is to quantify muscular and connective tissue volumes of extraocular muscles (EOM) in humans with no ophthalmological disease using stereology. EOM from five cadaveric non-strabismic humans were obtained. The number of muscle fibers in 5,000 µm2 and volume density (Vv) of muscle and collagen were measured using stereology. Comparisons between antagonist EOM were conducted using Wilcoxon signed rank test for paired samples. A secondary analysis examining differences between pairs of EOM was also conducted. Bilateral tests were performed, and significance was set at 0.05. The horizontal rectus muscles (medial and lateral rectus) had the highest Vv of muscle and the lowest Vv of collagen. The inferior rectus muscle tended to have a fewer number of fibers per 5,000 µm2 than the rest of the EOM. However, these differences did not reach statistical significance. This is the first published study describing the normal histology of human EOM using stereology. Our investigation, through the quantification of the proportion of muscle and collagen tissue, as well as the number of muscle fibers in 5,000 µ2, establishes normal stereological parameters for EOM of humans without ophthalmological disease.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200506en10.4067/S0717-95022021000200506
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Oculomotor muscles Humans Histology Anatomy
spellingShingle	Oculomotor muscles Humans Histology Anatomy San-Martín,J Luna,C Garretón,R Araneda,S Salgado,C Rodríguez,A Salgado,G Stereological Quantification of Extraocular Muscles in Humans
description	SUMMARY: The aim of this study is to quantify muscular and connective tissue volumes of extraocular muscles (EOM) in humans with no ophthalmological disease using stereology. EOM from five cadaveric non-strabismic humans were obtained. The number of muscle fibers in 5,000 µm2 and volume density (Vv) of muscle and collagen were measured using stereology. Comparisons between antagonist EOM were conducted using Wilcoxon signed rank test for paired samples. A secondary analysis examining differences between pairs of EOM was also conducted. Bilateral tests were performed, and significance was set at 0.05. The horizontal rectus muscles (medial and lateral rectus) had the highest Vv of muscle and the lowest Vv of collagen. The inferior rectus muscle tended to have a fewer number of fibers per 5,000 µm2 than the rest of the EOM. However, these differences did not reach statistical significance. This is the first published study describing the normal histology of human EOM using stereology. Our investigation, through the quantification of the proportion of muscle and collagen tissue, as well as the number of muscle fibers in 5,000 µ2, establishes normal stereological parameters for EOM of humans without ophthalmological disease.
author	San-Martín,J Luna,C Garretón,R Araneda,S Salgado,C Rodríguez,A Salgado,G
author_facet	San-Martín,J Luna,C Garretón,R Araneda,S Salgado,C Rodríguez,A Salgado,G
author_sort	San-Martín,J
title	Stereological Quantification of Extraocular Muscles in Humans
title_short	Stereological Quantification of Extraocular Muscles in Humans
title_full	Stereological Quantification of Extraocular Muscles in Humans
title_fullStr	Stereological Quantification of Extraocular Muscles in Humans
title_full_unstemmed	Stereological Quantification of Extraocular Muscles in Humans
title_sort	stereological quantification of extraocular muscles in humans
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200506
work_keys_str_mv	AT sanmartinj stereologicalquantificationofextraocularmusclesinhumans AT lunac stereologicalquantificationofextraocularmusclesinhumans AT garretonr stereologicalquantificationofextraocularmusclesinhumans AT aranedas stereologicalquantificationofextraocularmusclesinhumans AT salgadoc stereologicalquantificationofextraocularmusclesinhumans AT rodrigueza stereologicalquantificationofextraocularmusclesinhumans AT salgadog stereologicalquantificationofextraocularmusclesinhumans
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Stereological Quantification of Extraocular Muscles in Humans

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