Inflammatory Infiltrates in Melanocytic Lesions

SUMMARY: Inflammatory infiltrates are frequently present in melanocytic lesions, with different distribution and composition. Much attention has been devoted to tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment, establishing their prognostic and predictive value in many malignancies...

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Autores principales:	Relan,Alisha, Desar,Sabina, Dunnette,Brian, Shanley,Ryan, Giubellino,Alessio
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Inflammatory cells Lymphocytes Neutrophils Plasma cells Nevi Melanoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200512
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spelling	oai:scielo:S0717-950220210002005122021-04-22Inflammatory Infiltrates in Melanocytic LesionsRelan,AlishaDesar,SabinaDunnette,BrianShanley,RyanGiubellino,Alessio Inflammatory cells Lymphocytes Neutrophils Plasma cells Nevi Melanoma SUMMARY: Inflammatory infiltrates are frequently present in melanocytic lesions, with different distribution and composition. Much attention has been devoted to tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment, establishing their prognostic and predictive value in many malignancies, including melanoma. However, lymphocytes, albeit the most numerous and consistent presence, constitute only part of the immune microenvironment. Other inflammatory cells, including neutrophils, plasma cells, eosinophils and mast cells, are found in melanoma and other melanocytic lesions.Few studies offer a detailed count of these inflammatory infiltrates across the spectrum of melanocytic lesions. By using whole slide image analysis and open source software, in the present study we report the enumeration of different inflammatory infiltrates in benign melanocytic nevi, dysplastic nevi, melanoma in situ and invasive malignant melanomas. Significant higher numbers of plasma cells and neutrophils were observed in melanoma. These results indicate that composition of the inflammatory infiltrate may contribute to the diagnostic algorithm of melanocytic lesions.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200512en10.4067/S0717-95022021000200512
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Inflammatory cells Lymphocytes Neutrophils Plasma cells Nevi Melanoma
spellingShingle	Inflammatory cells Lymphocytes Neutrophils Plasma cells Nevi Melanoma Relan,Alisha Desar,Sabina Dunnette,Brian Shanley,Ryan Giubellino,Alessio Inflammatory Infiltrates in Melanocytic Lesions
description	SUMMARY: Inflammatory infiltrates are frequently present in melanocytic lesions, with different distribution and composition. Much attention has been devoted to tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment, establishing their prognostic and predictive value in many malignancies, including melanoma. However, lymphocytes, albeit the most numerous and consistent presence, constitute only part of the immune microenvironment. Other inflammatory cells, including neutrophils, plasma cells, eosinophils and mast cells, are found in melanoma and other melanocytic lesions.Few studies offer a detailed count of these inflammatory infiltrates across the spectrum of melanocytic lesions. By using whole slide image analysis and open source software, in the present study we report the enumeration of different inflammatory infiltrates in benign melanocytic nevi, dysplastic nevi, melanoma in situ and invasive malignant melanomas. Significant higher numbers of plasma cells and neutrophils were observed in melanoma. These results indicate that composition of the inflammatory infiltrate may contribute to the diagnostic algorithm of melanocytic lesions.
author	Relan,Alisha Desar,Sabina Dunnette,Brian Shanley,Ryan Giubellino,Alessio
author_facet	Relan,Alisha Desar,Sabina Dunnette,Brian Shanley,Ryan Giubellino,Alessio
author_sort	Relan,Alisha
title	Inflammatory Infiltrates in Melanocytic Lesions
title_short	Inflammatory Infiltrates in Melanocytic Lesions
title_full	Inflammatory Infiltrates in Melanocytic Lesions
title_fullStr	Inflammatory Infiltrates in Melanocytic Lesions
title_full_unstemmed	Inflammatory Infiltrates in Melanocytic Lesions
title_sort	inflammatory infiltrates in melanocytic lesions
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200512
work_keys_str_mv	AT relanalisha inflammatoryinfiltratesinmelanocyticlesions AT desarsabina inflammatoryinfiltratesinmelanocyticlesions AT dunnettebrian inflammatoryinfiltratesinmelanocyticlesions AT shanleyryan inflammatoryinfiltratesinmelanocyticlesions AT giubellinoalessio inflammatoryinfiltratesinmelanocyticlesions
_version_	1718445191912751104

Inflammatory Infiltrates in Melanocytic Lesions

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