Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats

SUMMARY: Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evalu...

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Autores principales:	Mahabady,Mahmood Khaksary, Tapebur,Mohammad Bahrami, Mazaheri,Yazdan, Tabandeh,Mohammad Reza, Tabatabaei,Seyed Reza Fatemi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Diabetic Aloe vera Nerve growth factor Hippocampus Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200577
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spelling	oai:scielo:S0717-950220210002005772021-04-22Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic RatsMahabady,Mahmood KhaksaryTapebur,Mohammad BahramiMazaheri,YazdanTabandeh,Mohammad RezaTabatabaei,Seyed Reza Fatemi Diabetic Aloe vera Nerve growth factor Hippocampus Rat SUMMARY: Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of Aloe vera gel on the hippocampus changes as well as the expression of nerve growth factor and receptors TrkA and P75 in the hippocampus of streptozotocin (STZ)-induced diabetic rats. 25 male Wistar rats were randomly divided into 5 groups including: control (normal saline), diabetic (normal saline), Aloe vera gel (400 mg/kg/day; gavage), diabetic + Aloe vera gel (400 mg/kg/day; gavage) and diabetic + insulin NPH (10 IU/kg/day; subcutaneous). Experimental diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneal). All groups treated for 8 weeks. At the end of treatment course, the rat brains were removed for measuring the expression of nerve growth factor, p75 and TrkA receptors were evaluated in the hippocampus. Diabetes induction after 8 weeks caused NGF and P75 expression levels in the diabetic group than other groups significantly increased (p<0.05). The TrkA receptor expression in the diabetic group compared with the control had a significant reduction (p<0.05). On the other hand in the diabetic group receiving Aloe vera gel expression of NGF and P75 expression levels compared to the diabetic group was significantly reduced (p<0.05) and the TrkA receptor expression compared with the diabetic group had a significant increase (p<0.05). The results showed that oral administration of Aloe vera gel in diabetic rats ameliorates diabetes-induced hyperglycemia. On the other hand, Aloe vera gel cause modulation of the expression of NGF neurotrophic factor via increased expression of TrkA receptor-specific and non-specific receptor down-regulation of P75 in the hippocampus of STZ-induced diabetic rats.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200577en10.4067/S0717-95022021000200577
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetic Aloe vera Nerve growth factor Hippocampus Rat
spellingShingle	Diabetic Aloe vera Nerve growth factor Hippocampus Rat Mahabady,Mahmood Khaksary Tapebur,Mohammad Bahrami Mazaheri,Yazdan Tabandeh,Mohammad Reza Tabatabaei,Seyed Reza Fatemi Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
description	SUMMARY: Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of Aloe vera gel on the hippocampus changes as well as the expression of nerve growth factor and receptors TrkA and P75 in the hippocampus of streptozotocin (STZ)-induced diabetic rats. 25 male Wistar rats were randomly divided into 5 groups including: control (normal saline), diabetic (normal saline), Aloe vera gel (400 mg/kg/day; gavage), diabetic + Aloe vera gel (400 mg/kg/day; gavage) and diabetic + insulin NPH (10 IU/kg/day; subcutaneous). Experimental diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneal). All groups treated for 8 weeks. At the end of treatment course, the rat brains were removed for measuring the expression of nerve growth factor, p75 and TrkA receptors were evaluated in the hippocampus. Diabetes induction after 8 weeks caused NGF and P75 expression levels in the diabetic group than other groups significantly increased (p<0.05). The TrkA receptor expression in the diabetic group compared with the control had a significant reduction (p<0.05). On the other hand in the diabetic group receiving Aloe vera gel expression of NGF and P75 expression levels compared to the diabetic group was significantly reduced (p<0.05) and the TrkA receptor expression compared with the diabetic group had a significant increase (p<0.05). The results showed that oral administration of Aloe vera gel in diabetic rats ameliorates diabetes-induced hyperglycemia. On the other hand, Aloe vera gel cause modulation of the expression of NGF neurotrophic factor via increased expression of TrkA receptor-specific and non-specific receptor down-regulation of P75 in the hippocampus of STZ-induced diabetic rats.
author	Mahabady,Mahmood Khaksary Tapebur,Mohammad Bahrami Mazaheri,Yazdan Tabandeh,Mohammad Reza Tabatabaei,Seyed Reza Fatemi
author_facet	Mahabady,Mahmood Khaksary Tapebur,Mohammad Bahrami Mazaheri,Yazdan Tabandeh,Mohammad Reza Tabatabaei,Seyed Reza Fatemi
author_sort	Mahabady,Mahmood Khaksary
title	Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
title_short	Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
title_full	Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
title_fullStr	Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
title_full_unstemmed	Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats
title_sort	effect of aloe vera on the expression of nerve factors, p75 and trka receptors in the hippocampus of diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200577
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Effect of Aloe vera on the Expression of Nerve Factors, p75 and TrkA Receptors in the Hippocampus of Diabetic Rats

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