Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)

SUMMARY: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2, are known to regulate blood vessel endothelium growth. They play important role in human and rodents teeth development. In newt jaws, there are sequential developmental teeth germs following behind the mature teeth. We exa...

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Autores principales:	Miwa,Yoko, Suzuki,Kingo, Sunohara,Masataka
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Vascular endothelial growth factor Amphibian Tooth germ
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200625
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spelling	oai:scielo:S0717-950220210002006252021-04-22Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)Miwa,YokoSuzuki,KingoSunohara,Masataka Vascular endothelial growth factor Amphibian Tooth germ SUMMARY: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2, are known to regulate blood vessel endothelium growth. They play important role in human and rodents teeth development. In newt jaws, there are sequential developmental teeth germs following behind the mature teeth. We examined the immunohistochemical localization of VEGF and its receptor and showed the specific expression pattern of VEGF and VEGF receptor in Cynops pyrrhogaster sequential tooth development. The intensity of immunoreactivity for VEGF in the inner enamel epithelium was weaker than that in the outer enamel epithelium in the dentine matrix formation and mineralization stages. Finally, at the enameloid maturation and enamel-like matrix formation stage, immunoreactivity for VEGF in inner enamel epithelium was stronger than in the outer enamel epithelium. The intensity of immunoreactivity for VEGFR-2 was positive for the outer enamel epithelium throughout tooth development. The crown sides of the odontoblasts were stained especially strongly for VEGF and VEGFR-2 during the dentine matrix formation and mineralization stage of the enameloid maturation and enamel- like matrix formation stage. We postulate that the expression of VEGF in the inner enamel epithelium and odontoblast widely effects tooth development in newts, as well as in human and rodents.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.2 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200625en10.4067/S0717-95022021000200625
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Vascular endothelial growth factor Amphibian Tooth germ
spellingShingle	Vascular endothelial growth factor Amphibian Tooth germ Miwa,Yoko Suzuki,Kingo Sunohara,Masataka Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
description	SUMMARY: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2, are known to regulate blood vessel endothelium growth. They play important role in human and rodents teeth development. In newt jaws, there are sequential developmental teeth germs following behind the mature teeth. We examined the immunohistochemical localization of VEGF and its receptor and showed the specific expression pattern of VEGF and VEGF receptor in Cynops pyrrhogaster sequential tooth development. The intensity of immunoreactivity for VEGF in the inner enamel epithelium was weaker than that in the outer enamel epithelium in the dentine matrix formation and mineralization stages. Finally, at the enameloid maturation and enamel-like matrix formation stage, immunoreactivity for VEGF in inner enamel epithelium was stronger than in the outer enamel epithelium. The intensity of immunoreactivity for VEGFR-2 was positive for the outer enamel epithelium throughout tooth development. The crown sides of the odontoblasts were stained especially strongly for VEGF and VEGFR-2 during the dentine matrix formation and mineralization stage of the enameloid maturation and enamel- like matrix formation stage. We postulate that the expression of VEGF in the inner enamel epithelium and odontoblast widely effects tooth development in newts, as well as in human and rodents.
author	Miwa,Yoko Suzuki,Kingo Sunohara,Masataka
author_facet	Miwa,Yoko Suzuki,Kingo Sunohara,Masataka
author_sort	Miwa,Yoko
title	Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
title_short	Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
title_full	Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
title_fullStr	Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
title_full_unstemmed	Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)
title_sort	immunohistochemical localization of vascular factors in tooth germ of amphibian (cynops pyrrhogaster)
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000200625
work_keys_str_mv	AT miwayoko immunohistochemicallocalizationofvascularfactorsintoothgermofamphibiancynopspyrrhogaster AT suzukikingo immunohistochemicallocalizationofvascularfactorsintoothgermofamphibiancynopspyrrhogaster AT sunoharamasataka immunohistochemicallocalizationofvascularfactorsintoothgermofamphibiancynopspyrrhogaster
_version_	1718445195121393664

Immunohistochemical Localization of Vascular Factors in Tooth Germ of Amphibian (Cynops pyrrhogaster)

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