MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia
SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role...
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Sociedad Chilena de Anatomía
2021
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oai:scielo:S0717-950220210003007542021-07-25MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral IschemiaDe-Russi,Brenno MarcoPorsani,Lucas BarbosaCirino,Mucio Luiz de AssisSilva,Jairo Pinheiro daTurra,Letícia PassiNovais,Paulo CezarLizarte-Neto,Fermino SanchesFazan,Valéria de Paula SassoliThomazini,José AntônioColli,Benedicto OscarTirapelli,Daniela Pretti da CunhaTirapelli,Luis FernandoCarvalho,Camila Albuquerque Melo de Cerebral ischemia Physical exercise MicroRNAs MicroRNA-27b SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of microRNAs in the pathophysiology of cerebral ischemia has been highlighted in current investigations. In addition, recent studies have also highlighted physical exercise as a possible protective factor both in the prevention and in the effects of cerebral ischemia, placing it as an important study resource. Thus, we investigated the role of physical exercise in experimental cerebral ischemia associated with the expression of microRNA-27b. 16 animals were used, divided into four experimental groups: Control, Physical Exercise, Cerebral Ischemia and Cerebral Ischemia associated with Physical Exercise. The real-time PCR methodology was used to analyze the expression of microRNA-27b. Although there were no statistically significant differences in the expression of microRNA-27b between the groups studied, the increased expression of microRNA-27b in the Physical Exercise group indicates its neuroprotective role in the pathophysiology of cerebral ischemia.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.3 20212021-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300754en10.4067/S0717-95022021000300754 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Cerebral ischemia Physical exercise MicroRNAs MicroRNA-27b |
| spellingShingle |
Cerebral ischemia Physical exercise MicroRNAs MicroRNA-27b De-Russi,Brenno Marco Porsani,Lucas Barbosa Cirino,Mucio Luiz de Assis Silva,Jairo Pinheiro da Turra,Letícia Passi Novais,Paulo Cezar Lizarte-Neto,Fermino Sanches Fazan,Valéria de Paula Sassoli Thomazini,José Antônio Colli,Benedicto Oscar Tirapelli,Daniela Pretti da Cunha Tirapelli,Luis Fernando Carvalho,Camila Albuquerque Melo de MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| description |
SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of microRNAs in the pathophysiology of cerebral ischemia has been highlighted in current investigations. In addition, recent studies have also highlighted physical exercise as a possible protective factor both in the prevention and in the effects of cerebral ischemia, placing it as an important study resource. Thus, we investigated the role of physical exercise in experimental cerebral ischemia associated with the expression of microRNA-27b. 16 animals were used, divided into four experimental groups: Control, Physical Exercise, Cerebral Ischemia and Cerebral Ischemia associated with Physical Exercise. The real-time PCR methodology was used to analyze the expression of microRNA-27b. Although there were no statistically significant differences in the expression of microRNA-27b between the groups studied, the increased expression of microRNA-27b in the Physical Exercise group indicates its neuroprotective role in the pathophysiology of cerebral ischemia. |
| author |
De-Russi,Brenno Marco Porsani,Lucas Barbosa Cirino,Mucio Luiz de Assis Silva,Jairo Pinheiro da Turra,Letícia Passi Novais,Paulo Cezar Lizarte-Neto,Fermino Sanches Fazan,Valéria de Paula Sassoli Thomazini,José Antônio Colli,Benedicto Oscar Tirapelli,Daniela Pretti da Cunha Tirapelli,Luis Fernando Carvalho,Camila Albuquerque Melo de |
| author_facet |
De-Russi,Brenno Marco Porsani,Lucas Barbosa Cirino,Mucio Luiz de Assis Silva,Jairo Pinheiro da Turra,Letícia Passi Novais,Paulo Cezar Lizarte-Neto,Fermino Sanches Fazan,Valéria de Paula Sassoli Thomazini,José Antônio Colli,Benedicto Oscar Tirapelli,Daniela Pretti da Cunha Tirapelli,Luis Fernando Carvalho,Camila Albuquerque Melo de |
| author_sort |
De-Russi,Brenno Marco |
| title |
MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| title_short |
MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| title_full |
MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| title_fullStr |
MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| title_full_unstemmed |
MicroRNA-27b Expression in Rats Submitted to Physical Exercise and Experimental Cerebral Ischemia |
| title_sort |
microrna-27b expression in rats submitted to physical exercise and experimental cerebral ischemia |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2021 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300754 |
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