Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity

SUMMARY: Age-associated decline of immune system, termed immunosenescence, is characterized by low-grade systemic inflammation, known as inflammaging, together with T-cell functional dysregulation. Although affecting all individuals, different environmental as well genetic factors impinge on the ind...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Merellano-Navarro,Eugenio, Olate-Briones,Alexandra, Norambuena-Mardones,Leandra, Rojas-Ramos,Vicente, Plata-Luna,Alexandra Márquez de la, Faúndez-Acuña,Jorge Y, Moraga,Javiera C, Escobedo,Noelia, Herrada,Andrés A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Immune system Naïve T cells Immunosenescence Inflammaging Elderly Physical activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300789
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022021000300789
record_format	dspace
spelling	oai:scielo:S0717-950220210003007892021-07-25Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical ActivityMerellano-Navarro,EugenioOlate-Briones,AlexandraNorambuena-Mardones,LeandraRojas-Ramos,VicentePlata-Luna,Alexandra Márquez de laFaúndez-Acuña,Jorge YMoraga,Javiera CEscobedo,NoeliaHerrada,Andrés A Immune system Naïve T cells Immunosenescence Inflammaging Elderly Physical activity SUMMARY: Age-associated decline of immune system, termed immunosenescence, is characterized by low-grade systemic inflammation, known as inflammaging, together with T-cell functional dysregulation. Although affecting all individuals, different environmental as well genetic factors impinge on the individual´s susceptibility or resilience to immunosenescence. Physical activity has been shown to improve autonomy and functionality in older adults. However, if physical activity affects immunosenescence or inflammaging remains unknown. The purpose of this study was to analyze immunosenescence and inflammaging in elderly individuals by measuring peripheral naïve T cells and interleukin (IL) -6 from peripheral blood and evaluate the impact of physical activity on T cell dysregulation and inflammaging. Thirty (30) elderly volunteers (10 males and 20 females), and 7 young controls (2 males ad 7 females), were recruited for this study. A methodology questionnaire was used to evaluate different parameters such as physical activity, and peripheral naïve CD4+ and CD8+ T cells and serum IL-6 were measured by FACS and ELISA respectively. Our results shown that naïve T cells decline, and IL-6 levels increase as older people age. Interestingly, we observed strong negative correlation between naïve T cells numbers and IL-6 levels in older adults, suggesting a direct link between reduced naïve T cell pool and increased inflammaging. Continuous physical activity during youth did not affect immunosenescence and inflammaging in elderly, but physical activity during elderly increase naïve T cell numbers and reduce inflammaging in older subjects. Our results showed reduced number of naïve T cells and increased levels of IL-6 as elder people get older. Moreover, the strong negative correlation between these parameters suggest that naïve T cells can have a direct suppressive activity over innate immune components. Furthermore, physical activity during elderly can reduce immunosenescence and inflammaging in older subjects.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.3 20212021-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300789en10.4067/S0717-95022021000300789
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Immune system Naïve T cells Immunosenescence Inflammaging Elderly Physical activity
spellingShingle	Immune system Naïve T cells Immunosenescence Inflammaging Elderly Physical activity Merellano-Navarro,Eugenio Olate-Briones,Alexandra Norambuena-Mardones,Leandra Rojas-Ramos,Vicente Plata-Luna,Alexandra Márquez de la Faúndez-Acuña,Jorge Y Moraga,Javiera C Escobedo,Noelia Herrada,Andrés A Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
description	SUMMARY: Age-associated decline of immune system, termed immunosenescence, is characterized by low-grade systemic inflammation, known as inflammaging, together with T-cell functional dysregulation. Although affecting all individuals, different environmental as well genetic factors impinge on the individual´s susceptibility or resilience to immunosenescence. Physical activity has been shown to improve autonomy and functionality in older adults. However, if physical activity affects immunosenescence or inflammaging remains unknown. The purpose of this study was to analyze immunosenescence and inflammaging in elderly individuals by measuring peripheral naïve T cells and interleukin (IL) -6 from peripheral blood and evaluate the impact of physical activity on T cell dysregulation and inflammaging. Thirty (30) elderly volunteers (10 males and 20 females), and 7 young controls (2 males ad 7 females), were recruited for this study. A methodology questionnaire was used to evaluate different parameters such as physical activity, and peripheral naïve CD4+ and CD8+ T cells and serum IL-6 were measured by FACS and ELISA respectively. Our results shown that naïve T cells decline, and IL-6 levels increase as older people age. Interestingly, we observed strong negative correlation between naïve T cells numbers and IL-6 levels in older adults, suggesting a direct link between reduced naïve T cell pool and increased inflammaging. Continuous physical activity during youth did not affect immunosenescence and inflammaging in elderly, but physical activity during elderly increase naïve T cell numbers and reduce inflammaging in older subjects. Our results showed reduced number of naïve T cells and increased levels of IL-6 as elder people get older. Moreover, the strong negative correlation between these parameters suggest that naïve T cells can have a direct suppressive activity over innate immune components. Furthermore, physical activity during elderly can reduce immunosenescence and inflammaging in older subjects.
author	Merellano-Navarro,Eugenio Olate-Briones,Alexandra Norambuena-Mardones,Leandra Rojas-Ramos,Vicente Plata-Luna,Alexandra Márquez de la Faúndez-Acuña,Jorge Y Moraga,Javiera C Escobedo,Noelia Herrada,Andrés A
author_facet	Merellano-Navarro,Eugenio Olate-Briones,Alexandra Norambuena-Mardones,Leandra Rojas-Ramos,Vicente Plata-Luna,Alexandra Márquez de la Faúndez-Acuña,Jorge Y Moraga,Javiera C Escobedo,Noelia Herrada,Andrés A
author_sort	Merellano-Navarro,Eugenio
title	Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
title_short	Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
title_full	Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
title_fullStr	Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
title_full_unstemmed	Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity
title_sort	reduced naïve t cell numbers correlate with increased low-grade systemic inflammation during ageing and can be modulated by physical activity
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300789
work_keys_str_mv	AT merellanonavarroeugenio reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT olatebrionesalexandra reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT norambuenamardonesleandra reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT rojasramosvicente reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT platalunaalexandramarquezdela reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT faundezacunajorgey reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT moragajavierac reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT escobedonoelia reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity AT herradaandresa reducednaivetcellnumberscorrelatewithincreasedlowgradesystemicinflammationduringageingandcanbemodulatedbyphysicalactivity
_version_	1718445200071720960

Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity

Ejemplares similares